A5101469588- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Nanoparticle-Based Drug Delivery
- Immune Cell Function and Interaction
- Oral microbiology and periodontitis research
- Epigenetics and DNA Methylation
- Dental Research and COVID-19
- Dental Implant Techniques and Outcomes
- Cancer Immunotherapy and Biomarkers
- Natural product bioactivities and synthesis
- RNA Interference and Gene Delivery
- interferon and immune responses
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Microbial Metabolic Engineering and Bioproduction
- Ginseng Biological Effects and Applications
- Mesenchymal stem cell research
- Hepatocellular Carcinoma Treatment and Prognosis
Dali University
2024
Henan Provincial People's Hospital
2020-2024
Zhengzhou University
2020-2024
Shihezi University
2023-2024
First Affiliated Hospital of Shihezi University Medical College
2022-2023
Chinese Academy of Sciences
2016-2023
Qingdao Institute of Bioenergy and Bioprocess Technology
2023
Fujian Academy of Agricultural Sciences
2023
Animal Science Research Institute
2023
Shandong University
2018-2021
The specific-targeting approach could promote the specificity of diagnosis and accuracy cancer treatment. choice a receptor is key step in this approach. Glypican-3 (GPC3) an oncofetal proteoglycan anchored on cell membrane. It overexpressed even early stage hepatocellular carcinoma (HCC), whereas it shows almost no expression healthy adult liver. Therefore, GPC3 may be applied as for HCC theranostics. In study, theranostics nanodevice, targeting peptide (named G12)-modified liposomes...
Enhancing cytosol delivery of exogenous antigens in antigen presenting cells can improve cross-presentation and CD8+ T cell-mediated immune response. The speed, which has great importance on the rate MHC class I molecules (MHC I) presentation pathway cytotoxic lymphocytes (CTLs) induction, not been well studied. We hypothesized that micelle-tailored vaccine with multiple cascaded lysosomal responsive capabilities could accelerate escape enhance cancer immunotherapy. To test our hypothesis,...
Compound K (CK; 20-O-D-glucopyranosyl-20(S)-protopanaxadiol), a major metabolite of ginsenoside, has been shown to possess several biological activities such as potent antitumor properties. However, the effect CK on apoptosis bladder cancer cells and its underlying mechanisms remain poorly understood. Therefore, we examined T 24 cells. Cell counts showed that treatment T24 with decreased cell number in dose- time-dependent manner. Flow cytometric analysis revealed could significantly induce...
Application of rapid on-site evaluation (ROSE) for thyroid fine needle aspiration (FNA) is controversial. Therefore, ROSE has not been universally applied. This study aimed to evaluate the value ultrasound-guided FNA.A total 997 patients with 1103 suspicious nodules had FNA performed from January 2016 February 2018. There were 513 and 590 without ROSE. The cytological nondiagnostic rate, passes, procedural times or compared. rates subsets further compared.There was no significant effect on...
Abstract Background Hepatocellular carcinoma (HCC) is one of the most deadly cancer worldwide. Multiple long noncoding RNAs (lncRNAs) are recently identified as crucial oncogenic factors or tumor suppressors. In this study, we explored functon and mechanism lncRNA double homeobox A pseudogene 8 (DUXAP8) in progression HCC. Methods Expression levels DUXAP8 HCC tissue samples were measured using qRT‐PCR. The association between pathological indexes expression was also analyzed. Human cell...
Lymph nodes are the main sites for immune activation and surveillance. Effective delivery of immunomodulators into lymph to trigger antitumor immunity is essential cancer treatment. Here, we propose a node strategy modulate response by activating cytotoxic T lymphocytes (CTLs) natural killer (NK) cells simultaneously. Novel pH/redox dual-sensitive micelles were prepared using poly(l-histidine)-poly(ethylene glycol) (PLH-PEG) as skeleton, which can effectively deliver due their suitable...
Abstract Tumor immune escape caused by low levels of tumor immunogenicity and checkpoint‐dependent suppression limits the immunotherapeutic effect. Herein, a “two‐way regulation” epigenetic therapeutic strategy is proposed using novel nano‐regulator that inhibits upregulating expression tumor‐associated antigens (TAAs) to improve downregulating programmed cell death 1 ligand (PD‐L1) block death‐1 (PD‐1)/PD‐L1. To engineer nano‐regulator, DNA methyltransferase (DNMT) inhibitor zebularine...
Glycerol 3-phosphate dehydrogenase 1 (GPD1) acts as a tumor suppressor in various types of cancer. However, the mechanisms GPD1 anti-tumor remain unclear breast This study aims to explore function and clinical relevance We confirmed that inhibited ability proliferation, migration, invasion overexpression cancer cells by CCK-8, wound healing, Transwell assays, respectively. found activated lipid synthesis pathway PI3K/AKT signaling pathway. The inhibitory effect on was also weakened after...
Protein tyrosine phosphatase non-receptor type 12 (PTPN12) is a recently identified tumor suppressor gene (TSG) that frequently compromised in human triple-negative breast cancer. In the present study, we investigated expression of PTPN12 protein by patients with cancer Chinese population and relationship between levels patient clinicopathological features prognosis. Additionally, explored underlying down-regulation mechanism from perspective an epigenetic alteration. We examined mRNA five...
Multidrug resistance (MDR) is a major cause of disease relapse and mortality in breast cancer. Paired‑related homeobox 1 (PRRX1) associated with the epithelial‑mesenchymal transition (EMT), which involved tumor development, including cell invasion MDR. However, effect PRRX1 on MDR had not clearly established. The present study investigated influence underlying molecular mechanisms MCF‑7 cancer cells. cells were divided into PRRX1+ group (cells transfected recombinant plasmid carrying gene),...
This study aimed to investigate the effects of sitagliptin on proliferation, apoptosis, inflammation, and osteogenic differentiation human periodontal ligament stem cells (hPDLSCs) in lipopolysaccharide (LPS)-induced inflammatory microenvironment its molecular mechanism.
The solvent-producing bacterium Clostridium acetobutylicum is able to grow on a variety of carbohydrates. main hexose transport system the phosphoenolpyruvate-dependent phosphotransferase (PTS). When gene glcG that encodes glucose transporter was inactivated, resulting mutant glcG::int(1224) grew as well wild type, yet its consumption reduced by 17% in batch fermentation. Transcriptomics analysis phosphate-limited continuous cultures showed cellobiose GlcCE highly up-regulated...
Myc proto‑oncogene (MYC) is an oncoprotein that promotes proliferation and apoptosis. MYC mutations frequently disrupt the apoptotic processes during tumorigenesis. In present study, effects of point mutation T58A on progression a cellular tumor antigen p53 (p53)‑/‑ human breast cancer cell line was analyzed, mechanism p53‑independent MYC‑induced apoptosis investigated. HCC1937 cells were transfected with mutant (T58A) or wild‑type (WT) using lentiviral vectors. The evaluated by colony...