A5100688114- Constructed Wetlands for Wastewater Treatment
- Wastewater Treatment and Nitrogen Removal
- Nanoplatforms for cancer theranostics
- Membrane Separation Technologies
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Coastal wetland ecosystem dynamics
- Pharmaceutical and Antibiotic Environmental Impacts
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Microbial Fuel Cells and Bioremediation
- Membrane-based Ion Separation Techniques
- Adsorption and biosorption for pollutant removal
- Phosphorus and nutrient management
- Immune Cell Function and Interaction
- Luminescence and Fluorescent Materials
- Oral microbiology and periodontitis research
- Water Treatment and Disinfection
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Microplastics and Plastic Pollution
- Cancer Immunotherapy and Biomarkers
- Wastewater Treatment and Reuse
Sichuan Agricultural University
2025
Shandong University
2016-2025
Ministry of Agriculture and Rural Affairs
2025
National Health and Family Planning Commission
2025
Development Research Center
2025
Ludong University
2025
North China University of Water Resources and Electric Power
2025
Beijing University of Chemical Technology
2025
Anhui Academy of Agricultural Sciences
2025
Rice Research Institute
2025
As a noninvasive treatment modality, ultrasound (US)-triggered sonodynamic therapy (SDT) shows broad and promising applications to overcome the drawbacks of traditional photodynamic (PDT) in combating cancer. However, SDT efficacy is still not satisfactory without oxygen (O2) assistance. In addition, there also much space explore SDT-based synergistic therapeutic modalities. Herein, novel Pt-CuS Janus composed hollow semiconductor CuS noble metallic Pt was rationally designed successfully...
Light-sensitive yolk–shell nanoparticles (YSNs) as remote-controlled and stimuli-responsive theranostic platforms provide an attractive method for synergistic cancer therapy. Herein, a kind of novel multifunctional YSNs has been successfully constructed by integrating star-shaped gold (Au star) the second near-infrared (NIR-II) photothermal yolks biodegradable crystalline zeolitic imidazolate framework-8 (ZIF-8) shells. In this platform, chemotherapeutic drug (doxorubicin hydrochloride, DOX)...
Abstract Sonodynamic therapy (SDT) activated by ultrasound is attractive as a potential alternative to conventional phototriggered therapies owing the deeper penetration depth and absence of phototoxicity. Nevertheless, low quantum yield nano‐sonosensitizer tumor hypoxia remain significant challenges for SDT. Herein, novel TiO 2 ‐based reported bilaterally enhance simultaneous integration precious metal Pt nanoparticles (NPs) an oxygen‐deficient layer. Furthermore, hollow cavity serves...
Abstract The development of highly efficient, multifunctional, and biocompatible sonosensitizer is still a priority for current sonodynamic therapy (SDT). Herein, defect‐rich Ti‐based metal–organic framework (MOF) (D‐MOF(Ti)) with greatly improved sonosensitizing effect simply constructed used enhanced SDT. Compared the commonly TiO 2 , D‐MOF(Ti) results in superior reactive oxygen species (ROS) yield under ultrasound (US) irradiation due to its narrow bandgap, which principally improves...
Photodynamic therapy (PDT) has emerged as an alternative treatment of cancers. However, the therapeutic efficiency PDT is severely limited by microenvironment insufficient oxygen (O
Recently, various metal peroxide nanomaterials have drawn increasing attention as an efficient hydrogen (H2O2) self-supplying agent for enhanced tumor therapy. However, a single kind of is insufficient to achieve more effective antitumor performance. Here, hyaluronic acid modified calcium and copper peroxides nanocomposite has been synthesized by simple one-step strategy. After accumulation at the site due permeability retention (EPR) effect specific recognition hyaluronate with CD44 protein...
Hypoxia and overexpression of glutathione (GSH) are typical characteristics the tumor microenvironment, which severely hinders cancer treatments. Here, we design a novel biodegradable therapeutic system, O2-Cu/ZIF-8@Ce6/ZIF-8@F127 (OCZCF), to simultaneously achieve GSH depletion O2-enhanced combination therapy. Notably, doped Cu2+ doubles O2 storage capacity ZIF-8 matrix, makes OCZCF an excellent pH-sensitive reservoir for conquering hypoxia, enhancing photodynamic therapy (PDT) efficiency...
The development and optimization of sonosensitizers for elevating intratumoral reactive oxygen species (ROS) are definitely appealing in current sonodynamic therapy (SDT). Given this, branched vanadium tetrasulfide (VS4 ) nanodendrites with a narrower bandgap (compared the most extensively explored sonosensitizers) presented as new source sonosensitizer, which allows more effortless separation sono-triggered electron-hole pairs ROS generation. Specifically, platinum (Pt) nanoparticles...
Recently, enzyme dynamic therapy (EDT) has drawn much attention as a new type of therapy. However, the selection suitable nanocarriers to deliver chloroperoxidase (CPO) and enhancement level hydrogen peroxide (H
The development of novel sonosensitizers with outstanding reactive oxygen (ROS) generation capacity and great biocompatibility poses a significant challenge for the clinical practice sonodynamic therapy (SDT). In this work, hemoglobin (Hb) natural metalloporphyrin was first shown to possess potential as sonosensitizer. Compared traditional organic sonosensitizers, Hb had satisfactory sono-sensitizing efficiency because four porphyrin molecules were separated by polypeptide chains. This...
Conventional sonodynamic therapy is unavoidably limited by the tumor microenvironment, although many sonosensitizers have been developed to improve them a certain extent. Given this, concept of sonocatalytic hydrogen evolution proposed, which defined as an oxygen-independent therapeutics. To demonstrate feasibility concept, narrow-bandgap semiconductor bismuth sulfide (Bi2 S3 ) selected sonocatalyst and platinum (Pt) nanoparticles are grown in situ optimize their catalytic performance. In...
Targeting tumour immunosuppressive microenvironment is a crucial strategy in immunotherapy. However, the critical role of lymph node (LN) immune (TLIME) homoeostasis often ignored. Here, we present nanoinducer, NIL-IM-Lip, that remodels suppressed TLIME via simultaneously mobilizing T and NK cells. The temperature-sensitive NIL-IM-Lip firstly delivered to tumours, then directed LNs following pH-sensitive shedding NGR motif MMP2-responsive release IL-15. IR780 1-MT induces immunogenic cell...