A5041981383- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- CAR-T cell therapy research
- Nanoparticles: synthesis and applications
- DNA and Nucleic Acid Chemistry
- Neuroscience and Neural Engineering
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Immune Cell Function and Interaction
- Zebrafish Biomedical Research Applications
- Cardiomyopathy and Myosin Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- RNA and protein synthesis mechanisms
- 3D Printing in Biomedical Research
- Immune cells in cancer
- Congenital heart defects research
- RNA Interference and Gene Delivery
- Single-cell and spatial transcriptomics
- TiO2 Photocatalysis and Solar Cells
- Cardiac Fibrosis and Remodeling
- Photoacoustic and Ultrasonic Imaging
- Cardiac electrophysiology and arrhythmias
- Quantum Dots Synthesis And Properties
Hong Kong Polytechnic University
2024-2025
Shenzhen Polytechnic
2024-2025
Purdue University West Lafayette
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Center for Cancer Research
2021-2023
Zhejiang Normal University
2021-2023
Purdue University Institute for Cancer Research
2023
State Key Laboratory of Cardiovascular Disease
2023
Nanjing University of Aeronautics and Astronautics
2023
Peking University Third Hospital
2021-2022
As a noninvasive treatment modality, ultrasound (US)-triggered sonodynamic therapy (SDT) shows broad and promising applications to overcome the drawbacks of traditional photodynamic (PDT) in combating cancer. However, SDT efficacy is still not satisfactory without oxygen (O2) assistance. In addition, there also much space explore SDT-based synergistic therapeutic modalities. Herein, novel Pt-CuS Janus composed hollow semiconductor CuS noble metallic Pt was rationally designed successfully...
Abstract Bismuth sulfide (Bi 2 S 3 ) nanomaterials are emerging as a promising theranostic platform for computed tomography imaging and photothermal therapy of cancer. Herein, the properties Bi nanorods (NRs) were unveiled to intensely correlate their intrinsic deep‐level defects (DLDs) that potentially could work electron–hole nonradiative recombination centers promote phonon production, ultimately leading performance. ‐Au heterojunction NRs designed hold more significant DLD properties,...
Gold (Au) core@void@copper sulfide (CuS) shell (Au–CuS) yolk–shell nanoparticles (YSNPs) were prepared in the present study for potential chemo-, photothermal, and photodynamic combination therapy, so-called "chemophototherapy". The resonance energy transfer (RET) process was utilized Au–CuS YSNPs to achieve both enhanced photothermal performance compared with those of CuS hollow (HNPs). A series Au nanomaterials as cores that had different localized surface plasmon (LSPR) absorption peaks...
Abstract Photodynamic therapy (PDT) efficacy has been severely limited by oxygen (O 2 ) deficiency in tumors and the electron–hole separation inefficiency photosensitizers, especially long‐range diffusion of O toward photosensitizers during PDT process. Herein, novel bismuth sulfide (Bi S 3 )@bismuth (Bi) Z‐scheme heterostructured nanorods (NRs) are designed to realize spatiotemporally synchronous self‐supply production reactive species for hypoxic tumor therapy. Both narrow‐bandgap Bi...
Abstract Glioblastoma (GBM) is one of the most aggressive and lethal solid tumors in human. While efficacious therapeutics, such as emerging chimeric antigen receptor (CAR)-T cells chemotherapeutics, have been developed to treat various cancers, their effectiveness GBM treatment has hindered largely by blood-brain barrier blood-brain-tumor barriers. Human neutrophils effectively cross physiological barriers display effector immunity against pathogens but short lifespan resistance genome...
Neutrophils, the most abundant white blood cells in circulation, are closely related to cancer development and progression. Healthy primary neutrophils present potent cytotoxicity against various cell lines through direct contact via generation of reactive oxygen species. However, due their short half-life resistance genetic modification, have not yet been engineered with chimeric antigen receptors (CARs) enhance antitumor for targeted immunotherapy. Here, we genetically human pluripotent...
Wound healing is a complex and sequential biological process that involves multiple stages. Although various nanomaterials are applied to accelerate the wound process, only single stage promoted during lacking hierarchical stimulation. Herein, hollow CeO2 nanoparticles (NPs) with rough surface l-arginine inside (Ah NPs) developed as compact programmable nanosystem for sequentially promoting hemostasis, inflammation, proliferation The of Ah NPs works nanobridge rapidly closure wounds,...
Nitric oxide (NO) molecular messenger can reverse the multidrug resistance (MDR) effect of cancer cells through reducing P-glycoprotein (P-gp) expression, beneficial for creating a favorable microenvironment treatment doxorubicin (Dox)-resistant cells. Development sophisticated nanosystems to programmably release NO and Dox becomes an efficient strategy overcome MDR obstacles achieve promising therapeutic effects in Dox-resistant cancer. Herein, stimulated nanosystem was designed engineer...
Stem cell-based therapy has been used to treat ischaemic heart diseases for two decades. However, optimal cell types and transplantation methods remain unclear. This study evaluated the therapeutic effects of human umbilical cord mesenchymal stem (hUCMSC) sheet on myocardial infarction (MI).hUCMSCs expressing luciferase were generated by lentiviral transduction in vivo bio-luminescent imaging tracking cells. We applied a temperature-responsive culture surface-based method form hUCMSC sheet....
The {101}–{001} surface heterojunction constructed on polyhedral titanium dioxide (TiO2) nanocrystals has recently been proposed to be favorable for the efficient electron–hole spatial separation due preferential accumulation of electron and hole {101} {001} facets, respectively. formed free can promote reactive oxygen species (ROS) production, which potentially used inactivation bacteria. In present study, a series truncated octahedral bipyramid TiO2 (T1, T2, T3, T4) coexposed with facets...
Simulated sunlight has promise as a light source able to alleviate the severe pain associated with patients during photodynamic therapy (PDT); however, low utilization efficiency of traditional photosensitizers dramatically limits its application. Titanium‐dioxide‐nanoparticle–gold‐nanocluster–graphene (TAG) heterogeneous nanocomposites are designed efficiently utilize simulated for melanoma skin cancer PDT. The narrow band gap in gold nanoclusters (Au NCs), and staggered energy bands...
Silver (Ag)-based nanoparticles (NPs) with a high potential of Ag+ release have been known to be capable promoting bacteria inactivation and the wound healing process; however, keeping steady flux levels in Ag-based NPs is still challenging. Herein, novel strategy terms altering intrinsic electronic structure Ag was attempted facilitate oxidation boost flux, as results improved antibacterial performance NPs. Gold (Au), platinum (Pt), palladium (Pd) were doped into tune their d band centers...
Rapid, robust virus-detection techniques with ultrahigh sensitivity and selectivity are required for the outbreak of pandemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Here, we report that femtomolar concentrations single-stranded ribonucleic acid (ssRNA) SARS-CoV-2 trigger ordering transitions in liquid crystal (LC) films decorated cationic surfactant complementary 15-mer deoxyribonucleic (ssDNA) probe. More importantly, LC...
Silver nanoparticles (Ag NPs) have promising plasmonic properties, however, they are rarely used in biomedical applications because of their potent toxicity. Herein, an electron compensation effect from Au to Ag was applied design safe Au@Ag core–shell NPs. The shell thickness precisely regulated enable the most efficient enrichment Au@Ag2.4 NPs, preventing oxidation and subsequent Ag+ ion release. X-ray photoelectron spectroscopy absorption near-edge structure analysis revealed transfer...
The development of sophisticated theranostic systems for simultaneous near infrared (NIR) fluorescence imaging and phototherapy is particular interest. Herein, anisotropic plasmonic metal heterostructures, Pt end-deposited Au nanorods (PEA NRs), are developed to efficiently produce hot electrons under 808 nm laser irradiation, exhibiting the strong electric density. These can release heat through electron-phonon relaxation form reactive oxygen species chemical transformation, as a result...
Biomimetic artificial surfaces that enable the manipulation of gas bubble mobility have been explored in a wide range applications nanomaterial synthesis, surface defouling, biomedical diagnostics, and therapeutics. Although many superhydrophobic isotropic-lubricant-infused porous developed to manipulate bubbles, simultaneous control over adhesion transport bubbles underwater remains challenge. Thermotropic liquid crystals (LCs), class structured fluids, provide an opportunity tune behavior...
Adoptive chimeric antigen receptor (CAR)-engineered natural killer (NK) cells have shown promise in treating various cancers. However, limited immunological memory and access to sufficient numbers of allogenic donor hindered their broader preclinical clinical applications. Here, we first assess eight different CAR constructs that use an anti-PD-L1 nanobody and/or universal anti-fluorescein (FITC) single-chain variable fragment (scFv) enhance antigen-specific proliferation anti-tumor...
Toxicological responses of nanomaterials have been closely correlated to their physicochemical properties, and establishment a property–activity relationship is favorable for deep understanding the nanomaterials' toxicity mechanism, prospectively predicting potential hazards rationally designing safer nanomaterials. Faceted usually exhibit more versatile effective performance than spherical due selectively exposed crystallographic facets with high densities unsaturated atoms. These surface...
Wound healing is a dynamic, interactive, and complex process, including multiple stages. Although various nanomaterials are applied to accelerate the wound process through exhibiting antibacterial activity or promoting cell proliferation, only single stage promoted during lowering efficacy. It necessary develop programmable nanosystems for stages in sequence. Herein, arginine-loaded detachable ceria-graphene nanocomposites (ACG NCs) were designed achieve this purpose. Ceria NPs graphene...
[Figure: see text].