A5102738966- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- Glaucoma and retinal disorders
- Immune Cell Function and Interaction
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Protein Hydrolysis and Bioactive Peptides
- T-cell and B-cell Immunology
- RNA modifications and cancer
- Inflammasome and immune disorders
- interferon and immune responses
- Circular RNAs in diseases
- Advanced biosensing and bioanalysis techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Salmonella and Campylobacter epidemiology
- Connexins and lens biology
- Advanced Nanomaterials in Catalysis
- Advanced Glycation End Products research
- Protein Tyrosine Phosphatases
- Synthesis of Indole Derivatives
- Intraocular Surgery and Lenses
- RNA Research and Splicing
Shanghai First People's Hospital
2018-2025
Shanghai Jiao Tong University
2018-2025
Zhejiang University of Science and Technology
2007-2024
Shanghai Clinical Research Center
2023-2024
South China University of Technology
2023-2024
Guangdong Academy of Agricultural Sciences
2023-2024
Shanghai Changzheng Hospital
2024
Shanghai Eye Disease Prevention & Treatment Center
2024
Hubei University of Medicine
2024
Taihe Hospital
2024
Subretinal fibrosis is a major cause of the poor visual prognosis for patients with neovascular age-related macular degeneration (nAMD). Myofibroblasts originated from retinal pigment epithelial (RPE) cells through epithelial-mesenchymal transition (EMT) contribute to formation. N6-Methyladenosine (m6A) modification has been implicated in EMT process and multiple fibrotic diseases. The role m6A EMT-related subretinal not yet elucidated. In this study, we found that during mouse model...
A simple and novel method for evaluating antioxidants in complex biological fluids has been developed based on the interaction of dye-labeled single-strand DNA (ssDNA) polydopamine (PDA). Due to between ssDNA PDA, fluorescence (e.g., FITC-ssDNA, as donor) can be quenched by PDA (as acceptor) "off" state through Förster resonance energy transfer (FRET). However, presence various antioxidants, such glutathione (GSH), ascorbic acid (AA), cysteine (Cys), homocysteine (Hcys), spontaneous...
A novel phosphine-catalyzed Friedel–Crafts reaction of naphthols with <italic>para</italic>-quinone methides has been developed.
Abstract Campylobacter concisus is an oral bacterium that associated with inflammatory bowel disease. C. has two major genomospecies, which appear to have different enteric pathogenic potential. Currently, no studies compared the genomes of strains from genomospecies. In this study, a comparative genome analysis 36 was conducted including 27 sequenced in study and nine publically available genomes. The core-genome defined genomospecies-specific genes were identified. core-genome,...
Abstract NOD‐like receptor protein 3 (NLRP3) is associated with age‐related macular degeneration (AMD). Retinal pigment epithelial (RPE) cells serve as the immune defense of macula, and their dysfunction causes clinically relevant changes in AMD. In present study, oxidized low‐density lipoprotein (ox‐LDL) activated NLRP3 inflammasome human RPE cell line ARPE‐19. Our data showed that expression NLRP3, interleukin‐1β (IL‐1β), caspase‐1 release IL‐1β ARPE‐19 were substantially increased by...
Rationale: Amyloid β (Aβ) deposition, an essential pathological process in age-related macular degeneration (AMD), causes retinal pigment epithelium (RPE) driven mostly by oxidative stress. However, despite intense investigations, the extent to which overoxidation contributes Aβ-mediated RPE damage and its potential mechanism has not been fully elucidated. Methods: We performed tandem mass-tagged (TMT) mass spectrometry (MS) bioinformatic analysis of RPE-choroid complex Aβ1-40-induced mouse...
Neovascular age-related macular degeneration (nAMD), characterized by choroidal neovascularization (CNV), is one of the leading causes severe visual impairment and irreversible vision loss around world. Subretinal fibrosis (SRF) contributes to incomplete response anti-vascular endothelial growth factor (VEGF) treatment main reasons for long-term poor outcomes in nAMD. Reducing SRF urgently needed anti-VEGF era. The role non-coding RNAs has been implicated CNV; however, their roles have not...
BACKGROUND Colorectal cancer (CRC) is the third-most prevalent and with second-highest mortality rate worldwide, representing a high public health burden. Deep learning (DL) offers advantages in diagnosis, identification, localization, classification prognosis of CRC patients. However, few bibliometric analyses research hotspots trends field have been performed. AIM To use approaches to analyze visualize current state development trend DL as well anticipate future directions hotspots....
Abstract Amyloid β (Aβ) is a crucial component of drusen, the hallmark early stage age‐related macular degeneration (AMD), and can cause retinal pigment epithelium (RPE) cell damage through activation inflammatory response. MicroRNAs play critical role in inflammation. However, mechanism underlying effect microRNAs on NLRP3 inflammasome induced by Aβ remains poorly understood. In present study, we demonstrated that 1‐40 ‐mediated RPE inducing decrease endogenous miR‐191‐5p expression. This...
Abstract Amyloid‐β (Aβ) is thought to be a critical pathologic factor of retinal pigment epithelium (RPE) degeneration in age‐related macular (AMD). Aβ induces inflammatory responses RPE cells and recent studies demonstrate the N6‐methyladenosine (m6A) regulatory role cell inflammation. m6A reversible epigenetic posttranslational modification, but its relationship with Aβ‐induced yet thoroughly investigated. The present study explored mechanism model. This model was induced via...
Retinitis pigmentosa (RP) is a monogenic disease characterized by irreversible degeneration of the retina. PRPF31, second most common causative gene autosomal dominant RP, frequently harbors copy number variations (CNVs), but underlying mechanism unclear. In this study, we summarized phenotypic and genotypic characteristics 18 RP families (F01-F18) with variants in PRPF31. The prevalence PRPF31 our cohort Chinese was 1.7% (18/1024). Seventeen different were detected, including eight novel...