A5110566594- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Machine Learning in Bioinformatics
- Advanced Authentication Protocols Security
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- User Authentication and Security Systems
- Computational Drug Discovery Methods
- Circular RNAs in diseases
- RNA modifications and cancer
- Methane Hydrates and Related Phenomena
- Gene expression and cancer classification
- Data Mining Algorithms and Applications
- Microbial Community Ecology and Physiology
- Network Security and Intrusion Detection
- RNA Research and Splicing
- Biomedical Text Mining and Ontologies
- Cancer Cells and Metastasis
- Single-cell and spatial transcriptomics
- Constructed Wetlands for Wastewater Treatment
- Coastal wetland ecosystem dynamics
- Metabolism, Diabetes, and Cancer
- Protein Structure and Dynamics
- Phosphorus and nutrient management
- Genomics and Phylogenetic Studies
Guangxi University
2016-2025
Monash University
2025
Henan Institute of Technology
2025
Nanchang University
2023-2025
Shandong Normal University
2019-2025
Qilu University of Technology
2018-2024
Yunnan University
2023-2024
Shandong Academy of Sciences
2016-2024
Fujian Medical University
2016-2024
Union Hospital
2016-2024
The aim of the present study was to investigate anticancer effects and potential mechanisms polyphenol epigallocatechin-3-gallate (EGCG) on breast cancer MCF-7 cells in vitro vivo. Our results showed that EGCG significantly inhibited cell viability a time- dose-dependent manner. Flow cytometry analysis indicated induced apoptosis disrupted cycle progression at G2/M phase. Moreover, miR-25 expression increased PARP, pro-caspase-3 pro-caspase-9 protein levels. Restoration EGCG-induced...
Mammalian two-pore channels (TPCs) regulate the physiological functions of endolysosome. Here we present cryo-EM structures human TPC2 (HsTPC2), a phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2)-activated, Na+ selective channel, in ligand-bound and apo states. The structure captures closed conformation, while form features channel both open conformations. Combined with functional analysis, these provide insights into mechanism PI(3,5)P2-regulated gating TPC2, which is distinct from that...
It has been proved that long noncoding RNA (lncRNA) plays critical roles in many human diseases. Therefore, inferring associations between lncRNAs and diseases can contribute to disease diagnosis, prognosis treatment. To overcome the limitation of traditional experimental methods such as expensive time-consuming, several computational have proposed predict lncRNA-disease by fusing different biological data. However, prediction performance identification needs be improved. In this study, we...
In the past 37 years, human immunodeficiency virus/acquired syndrome (HIV/AIDS) has undergone various major transmission routes in China, with world most complex co-circulating HIV-1 subtypes, even prevalence is still low. response to first epidemic outbreak of HIV injecting drug users and second one by illegal commercial blood collection, China issued Anti-Drug Law launched Blood Donation Act nationwide nucleic acid testing, which avoided 98,232 211,200 estimated infections almost ended...
Detecting anomalies for dynamic graphs has drawn increasing attention due to their wide applications in social networks, e-commerce, and cybersecurity. Recent deep learning-based approaches have shown promising results over shallow methods. However, they fail address two core challenges of anomaly detection graphs: the lack informative encoding unattributed nodes difficulty learning discriminate knowledge from coupled spatial-temporal graphs. To overcome these challenges, this paper, we...
Livestock wastewater is an important source of agricultural non-point pollution, causes serious pollution to water bodies. At the same time, corn straw also waste, and its resource utilization has been focus global attention. The novel biochar material made from stalk can be used treat livestock wastewater, which helpful control improve efficiency waste utilization. A chitosan modified magnesium impregnated (CS-MgCBC) was synthetic for removal NH4+-N PO43−-P wastewater. experiments results...
Multiview subspace clustering (MVSC) has been used to explore the internal structure of multiview datasets by revealing unique information from different views. Most existing methods ignore consistent and angular In this article, we propose a novel MVSC via low-rank symmetric affinity graph (LSGMC) tackle these problems. Specifically, considering information, pursue across views decomposing coefficient matrix into three factors. Then, symmetry constraint is utilized guarantee weight...
Sepsis‑induced cardiomyopathy (SIC) is a manifestation of multiple organ failure as result sepsis and serious threat to life. Here, the effect mechanisms quercetin (QUE) in SIC were assessed. It was found that patients with expressed lower serum levels glutathione peroxidase 4 (GPX4) SIRT1 but higher CK‑MB, cTnI, TNF‑α, IL‑6 compared healthy individuals. A dose 80 µM QUE increased viability reduced ferroptosis H9C2 cells treated 1.0 µg/ml LPS vitro. The administration decreased MDA, NADPH,...
Abstract Background and objectives Comprehensive analysis of multi-omics data is crucial for accurately formulating effective treatment plans complex diseases. Supervised ensemble methods have gained popularity in recent years analysis. However, existing research based on supervised learning algorithms often fails to fully harness the information from unlabeled nodes overlooks latent features within among different omics, as well various associations features. Here, we present a novel...
CircRNA has been shown to be involved in the occurrence of many diseases. Several computational frameworks have proposed identify circRNA-disease associations. Despite existing methods obtained considerable successes, these still require improved as their performance may degrade due sparsity data and problem memory overflow. We develop a novel framework called LGCDA predict associations by fusing local global features solve above mentioned problems. First, we construct closed subgraphs using...
The steel box girder bridge is a structure composed of mutually vertical stiffening ribs (longitudinal and transverse ribs) that carry the loads vehicles. Since external are usually complex variable, rational design components topic deserves more attention. purpose this study to explore optimal range some component parameters, expecting reduce costs while ensuring stress-carrying capacity. A finite element model (FEM) based on ABAQUS was built results were verified by laboratory experiments....
Histone lysine methylation is an important epigenetic modification in regulating chromatin structure and gene expression. H3 4 (H3K4me), which can be a mono-, di-, or trimethylated state, has been shown to play role expression involved plant developmental control stress adaptation. However, the resetting mechanism of this not yet fully understood. In work, we identified JmjC domain-containing protein, JMJ703, as histone demethylase that specifically reverses all three forms H3K4me rice....