A5101786363- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Metabolomics and Mass Spectrometry Studies
- Advanced Chemical Sensor Technologies
- Analytical chemistry methods development
- Advanced Proteomics Techniques and Applications
- Ion-surface interactions and analysis
- Isotope Analysis in Ecology
- Advanced Photocatalysis Techniques
- Forensic Fingerprint Detection Methods
- Pesticide Residue Analysis and Safety
- Identification and Quantification in Food
- Electrochemical Analysis and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Electrohydrodynamics and Fluid Dynamics
- Iron oxide chemistry and applications
- Copper-based nanomaterials and applications
- Melamine detection and toxicity
- Catalytic Processes in Materials Science
- Radioactive element chemistry and processing
- Molecular Sensors and Ion Detection
- Ammonia Synthesis and Nitrogen Reduction
- Chemical Reaction Mechanisms
- Pharmacological Effects and Assays
- Toxic Organic Pollutants Impact
Jiangxi University of Traditional Chinese Medicine
2022-2025
Chongqing Medical University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
East China University of Technology
2015-2024
Shenzhen University
2022-2024
National Taiwan University
2021-2022
Jilin University
2006-2020
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry
2016-2020
Jilin Medical University
2017-2020
Materials Science & Engineering
2020
On-line droplet–droplet extraction occurs when a sample spray intersects reagent electrospray; this allows continuous analysis of trace amounts compounds directly in complex matrices including undiluted urine, milk and polluted water over extended periods time.
Desorption electrospray ionization (DESI) mass spectrometry is used to detect trace amounts of explosives present on a variety ambient surfaces in 5-second analysis times without any sample preparation.
Desorption electrospray ionization (DESI), an ambient mass spectrometry technique, is used for trace detection of the explosives trinitrohexahydro-1,3,5-triazine (RDX), octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), 2,4,6-trinitrotoluene (TNT), Pentaerythritol tetranitrate (PETN), and their plastic compositions (Composition C-4, Semtex-H, Detasheet) directly from a wide variety surfaces (metal, plastic, paper, polymer) without sample preparation or pretreatment. Analysis performed...
Desorption electrospray ionization (DESI) allows mass spectrometry to be used for on-line high-throughput monitoring of pharmaceutical samples in the ambient environment, without prior sample preparation. Positive and negative ion DESI are characterize active ingredients formulated as tablets, ointments, liquids. Compounds a wide variety chemical types detected these complex matrices. The effects on analytical performance operating parameters, including high voltage, heated capillary...
Without any sample pretreatment, trace amounts of melamine in various milk products were rapidly detected noting the characteristic fragments (i.e., m/z 110, 85, and 60) MS/MS spectrum protonated molecules (m/z 127) recorded by using surface desorption atmospheric pressure chemical ionization mass spectrometry. Signal responses most abundant ionic fragment 85) well correlated with melaime products, showing a dynamic range about 5 orders magnitude. The limit detection (LOD) was found to be...
A novel method based on ultrasound-assisted EESI-MS has been developed and applied to rapidly detect the presence of melamine in raw milk, wheat gluten milk powder with no or minor sample pre-treatment; high throughput figures merit make it specially useful for screening levels well below current safety limit various food matrices.
A blow-by-blow account: Extractive electrospray ionization (EESI) quadrupole TOF (QTOF) mass spectrometry has been established with a commercial instrument without hardware modification for the rapid analysis of breath sample pretreatment (see picture). Sulfur-containing compounds can be selectively detected by using silver cationization in EESI source—a method interest vivo metabolic studies and clinical diagnosis.
Electrospray ionization (ESI) is a mass spectrometric technique widely used in various fields including chemistry, biology, medicine, pharmaceutical industry, clinical assessment, and forensic science. In this study, we report simple economical ESI-mass spectrometry (MS) technique, which makes use of disposable wooden tips (wooden toothpicks) for loading samples. Samples could be loaded by normal pipetting onto the tip or simply dipping into sample solutions. The hydrophilic porous nature...
MS comes to life: A novel method sample surfaces of biological objects uses a neutral gas beam for in vivo EESI mass spectrometric analysis without pretreatment (see picture; QTOF=quadropole time-of-flight). The sampling process results rapid analyses with reduced ion suppression and chemical contamination. This strategy can be used food quality monitoring, homeland security, metabolomics, clinical diagnosis. Supporting information this article is available on the WWW under...
Extractive electrospray ionization (EESI) is a powerful ambient technique that can provide comprehensive mass spectrometric (MS) information on aerosols, complex liquids, or suspensions without any sample pretreatment. An understanding of the EESI mechanism critical for defining its range application, advantages, and limitations EESI, improving repeatability, sensitivity, selectivity. However, no systematic study mechanisms has been conducted so far. In this work, fluorescence studies in...
Abstract Photo‐electrochemical (PEC) water splitting is a promising method for converting solar energy into clean energy, but the mechanism of improving PEC efficiency through interfacial contact and defect strategy remains highly controversial. Herein, reduced graphene oxide (rGO) oxygen vacancies are introduced α ‐Fe 2 O 3 nanorod (NR) arrays using simple spin‐coating acid treatment. The resultant vacancy– /rGO‐integrated system exhibits higher photocurrent, four times than pristine . It...
Abstract The growth and sustainable development of humanity is heavily dependent upon molecular nitrogen (N 2 ) fixation. Herein we discover ambient catalyst-free disproportionation N by water plasma which occurs via the distinctive HONH-HNOH +• intermediate to yield economically valuable nitroxyl (HNO) hydroxylamine (NH OH) products. Calculations suggest that reaction prompted coordination electronically excited with dimer radical cation, (H O) , in its two-center-three-electron...
Nano-drug delivery systems (NDDS) have become a promising alternative and adjunctive strategy for lung cancer (LC) treatment. However, comprehensive bibliometric analyses examining global research efforts on NDDS in LC are scarce. This study aims to fill this gap by identifying key trends, emerging hotspots, collaboration networks within the field of LC. A total 2452 publications, spanning from 1998 2024, were extracted Web Science Core Collection. The data analyzed using tools such as...
Ambient mass spectrometry, pioneered with desorption electrospray ionization (DESI) technique, is of increasing interest in recent years. In this study, a corona discharge source adapted for direct surface chemical compounds on various surfaces at atmospheric pressure. air, about 60% relative humidity, used as reagent to generate primary ions such H(3)O(+), which then directed impact the sample and ionization. Under experimental conditions, protonated or deprotonated molecules analytes...
Abstract Desorption electrospray ionization mass spectrometry (DESI‐MS) and nuclear magnetic resonance (NMR) spectroscopy are used to provide data on urine examined without sample preparation allow differentiation between diseased (lung cancer) healthy mice. Principal component analysis (PCA) is shortlist compounds with potential for biomarker screening which responsible significant differences control samples from animals. Similar PCA score plots have been achieved by DESI‐MS NMR, using a...
Abstract It is of increasing interest and practical importance to develop convenient methods based on mass spectrometry for high‐throughput analyses biological samples. This usually difficult because the complex matrix ion suppression effects. Generation ions at ambient conditions a promising solution these problems sample easily accessible effect reduced significantly. A new method rapid on‐line detection metabolic markers in samples described here. combines atmospheric pressure desorption...
Abstract A highly anti ‐selective asymmetric Henry reaction has been developed, affording synthetically versatile β‐nitroalcohols in a predominately manner (mostly above 15:1) and excellent ee values 95 %). Moreover, the was carried out presence of water for first time with up to 99 % . The catalytic mechanism proposed based on detection intermediates by extractive electrospray ionization mass spectrometry (EESI‐MS). Furthermore, adducts have successfully transformed into biochemically...
“Soft” ionization: EESI deposits charges on native proteins, which are separated from any high electric field. In this way proteins can be characterized by mass spectrometry even raw biological samples without significant conformational changes or reduction in activity. EESI-MS is a sensitive tool for the high-throughput analysis of trace levels under conditions.
Analysis of biological tissue at a molecular level is great importance in biological, medical and clinical studies. In this manuscript, we report that both plant animal tissues can be directly ionized analyzed by mass spectrometry under ambient conditions. By adding some solvents applying high voltage, spray ionization induced the tip spectrum observed. Various have been tested compounds such as lipids, alkaloids, glucosides, lignans, pharmaceuticals proteins could detected spectra. This new...
The effects of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in women on the gestation course and health fetus, particularly first second trimesters, remain very poorly explored. This report describes a case which normal development pregnancy was complicated immediately after patient had experienced Coronavirus disease 2019 (COVID-19) at 21st week gestation. Specific conditions included critical blood flow fetal umbilical artery, growth restriction (1st percentile),...
The effect of diet on metabolites found in rat urine samples has been investigated using nuclear magnetic resonance (NMR) and a new ambient ionization mass spectrometry experiment, extractive electrospray (EESI-MS). Urine from rats with three different dietary regimens were readily distinguished multivariate statistical analysis detected by NMR MS. To observe the metabolic pathways, related to specific pathways also analysis. Discrimination is increased making observations restricted...