A5100551657- Nutritional Studies and Diet
- Inflammasome and immune disorders
- Ammonia Synthesis and Nitrogen Reduction
- Esophageal Cancer Research and Treatment
- Catalytic Processes in Materials Science
- Diet, Metabolism, and Disease
- Eicosanoids and Hypertension Pharmacology
- Nutrition, Genetics, and Disease
- Respiratory Support and Mechanisms
- Advanced Photocatalysis Techniques
- Liver Disease Diagnosis and Treatment
- Modular Robots and Swarm Intelligence
- Analytical Chemistry and Chromatography
- Gastrointestinal disorders and treatments
- RNA modifications and cancer
- Climate variability and models
- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- Advanced Chemical Sensor Technologies
- Esophageal and GI Pathology
- Animal Virus Infections Studies
- Cardiac Health and Mental Health
- Helicobacter pylori-related gastroenterology studies
- Advanced Materials and Mechanics
- Fermentation and Sensory Analysis
Lanzhou University
2023-2025
Nanjing University of Chinese Medicine
2024-2025
First Affiliated Hospital of Xinjiang Medical University
2025
Xinjiang Medical University
2025
First Hospital of Lanzhou University
2023-2024
East China University of Technology
2023-2024
Shandong Academy of Sciences
2024
Qilu University of Technology
2023-2024
Sichuan Agricultural University
2024
Ministry of Education of the People's Republic of China
2024
Abstract The growth and sustainable development of humanity is heavily dependent upon molecular nitrogen (N 2 ) fixation. Herein we discover ambient catalyst-free disproportionation N by water plasma which occurs via the distinctive HONH-HNOH +• intermediate to yield economically valuable nitroxyl (HNO) hydroxylamine (NH OH) products. Calculations suggest that reaction prompted coordination electronically excited with dimer radical cation, (H O) , in its two-center-three-electron...
Abstract Renal tubular atrophy is a hallmark of chronic kidney disease. The cause atrophy, however, remains elusive. Here we report that reduction renal cell polynucleotide phosphorylase (PNPT1) causes translation arrest and atrophy. Analysis atrophic tissues from dysfunction patients male mice with ischemia-reperfusion injuries (IRI) or unilateral ureteral obstruction (UUO) treatment shows PNPT1 markedly downregulated under conditions. leads to leakage mitochondrial double-stranded RNA...
Production of flavors from natural substrates by microbial transformation has become a growing and expanding field study over the past decades. Vanillin, major component vanilla flavor, is principal flavoring compound used worldwide. Streptomyces sp. strain V-1 known to be one most promising producers vanillin ferulic acid. Although identification genes involved in biotransformation acid been previously reported, purification detailed characterization corresponding enzymes with important...
Abstract Background Salmonella infection in livestock and poultry causes salmonellosis, is mainly treated using antibiotics. However, the misuse use of antibiotics often triggers emergence multi-drug-resistant strains. Currently, phages safe effective against , serving as best drug choice. This study involved 16 bacteriophages separated purified from sewage feces broiler farm. A phage, vB_SalP_LDW16, was selected based on phage host range test. The vB_SalP_LDW16 characterized by double-layer...
Diabetic neuropathy (DN), a common and debilitating complication of diabetes, significantly impairs the quality life affected individuals. While multiple studies have indicated changes in expression specific matrix metalloproteinases (MMPs) patients with DN, basic research has reported impact MMPs on there is lack systematic causal relationship remains unclear. The objective this to investigate casual between DN through two-sample Mendelian randomization (MR). Data for investigation were...
The purpose of this study was to investigate the effects aromatherapy and acupoint herbal patching on fatigue sleep disorders in people living with HIV (PLWH). Aromatherapy are ancient alternative therapies traditional Chinese medicine. We randomly selected 90 patients from Nanjing Public Health Medical Center China divided them into three groups: group, group control group. They were supposed fill Pittsburgh Sleepiness Index Scale (PSQI), Piper Fatigue (PFS), Liver Depression Spleen...
Colorectal cancer (CRC) is one of the most common cancers worldwide, necessitating identification risk factors and preventive measures. Fatty acids, vital nutrients involved in various bodily functions, have been linked to CRC; however, findings are inconsistent. This Mendelian randomization study utilized data from UK Biobank included 18 fatty acid-related phenotypes. We used single-nucleotide polymorphisms as instrumental variables examine Causal connections between acids CRC. Statistical...
Nonalcoholic fatty liver disease (NAFLD) is a growing global health concern linked to obesity. This study employed Mendelian randomization approach explore the causal influence of BMI on metabolic biomarkers and subsequent risk NAFLD. We analyzed data from multiple sources, including 249 traits, establish direct mediating relationships among BMI, factors, NAFLD risk. Our findings revealed significant positive correlation between across various datasets. identified 176 metabolites associated...
This study aims to identify specific molecular targets sensitive AZD6738 through the integration of network pharmacology and transcriptomic methods, assess their potential role in treatment hepatocellular carcinoma (HCC). Additionally, we explore effects on tumor microenvironment its ability regulate immune responses. We employed a combination analysis molecules associated with HCC, including EZH2, CCNB1, PRKDC, CTSL, PSEN1, SLC6A3, FKBP1A. Using these clinical features, constructed robust...
ABSTRACT Infectious bronchitis virus (IBV) is caused by avian coronavirus and poses a global economic threat to the poultry industry. In 2023, highly pathogenic IBV strain, IBV/CN/GD20230501, was isolated identified from chickens vaccinated with IBV-M41 in Guangdong, China. This study comprehensively investigated biological characteristics of including its genotype, whole genome sequence analysis S1 gene, pathogenicity, host immune response, serum non-targeted metabolomics. Through gene...
The positions of C═C bonds in unsaturated fatty acids (FAs) are one the main factors determining quality food flavor. Herein, we developed an approach for determination FAs by online epoxidation reaction with water dimer radical cations. limit detection octenoic acid isomers was ∼9 μg/L. trans-2/3-hexenoic acid, trans-2/3-octenoic oleic linoleic and linolenic black tea or olive oil samples were directly determined established method. These results indicate that method allows rapid oil....
The composition and ratio of unsaturated fatty acids in vegetable oils play a crucial role determining their overall quality. In this study, we present corona discharge ionization mass spectrometry (MS) method for the rapid differentiation oil varieties geographical origins under environmental conditions. Abundant water dimer radical cations, (H
Fe-based N-doped carbon materials have become the most potential electrocatalysts to replace noble metal catalysts in oxygen reduction reaction (ORR) due their wide availability, affordability, and high catalytic activity. In this study, novel Fe3C nanoparticles encapsulated by mesopores were prepared via a cost-effective method using MIL-100(Fe) growth on CTF as precursor. Benefit from compositional structural synergistic effect of substrate, highly dispersed core–shell Fe/Fe3[email...
Acute kidney injury (AKI) presents a daunting challenge with limited therapeutic options. To explore the contribution of N6-methyladenosine (m6A) in AKI development, we have investigated m6A-modified mRNAs within renal tubular cells subjected to injuries induced by diverse stressors. Notably, while overall level RNA remains unaltered facing stress, distinct phenomenon emerges-mRNAs bearing m6A methylation exhibit pronounced tendency accumulate stress granules (SGs), structures response these...
The principal treatment modalities for esophageal cancer are radiation, chemotherapy and surgery or a combination of them. In some sense, technological advances have tremendously heightened patients’ survival rates. Nevertheless, the debate on prognostic value postoperative radiotherapy (PORT) has never ceased. On that account, this study made an effort to probe deep into effects PORT prognosis stage III cancer. Our included patients diagnosed with between 2004 2015 through Surveillance,...
Conformer models have achieved state-of-the-art(SOTA) results in end-to-end speech recognition. However mainly focuses on temporal modeling while pays less attention time-frequency property of feature. In this paper we augment with ConvNeXt and propose Nextformer structure. We use stacks block to replace the commonly used subsampling module for utilizing information contained Besides, insert an additional downsampling middle layers make our model more efficient accurate. conduct experiments...
Programmable magnetic soft grippers are highly desirable for diverse applications in drug delivery, object manipulation, and robotics. However, current programming need to be driven by multiple physical fields, which complicated operate single motion. Here, a method patterning hard microparticles an elastomer matrix is reported. Based on digital light processing (DLP), this uses controlled reorientation of particles selective exposure ultraviolet (UV) encode polydimethylsiloxane (PDMS)...
Background Pediatric cerebral palsy (CP) is a non-progressive brain injury syndrome characterized by central motor dysfunction and insufficient coordination ability. The etiology of CP complex often accompanied diverse complications such as intellectual disability language disorders, making clinical treatment difficult. Despite the availability pharmacological interventions, rehabilitation programs, spasticity relief surgery options for CP, their effectiveness still constrained....
Abdominal multi-organ segmentation is one of the most important topics in field medical image analysis, and it plays an role supporting clinical workflows such as disease diagnosis treatment planning. In this study, efficient method called Swin-PSAxialNet based on nnU-Net architecture proposed. It was designed specifically for precise 11 abdominal organs CT images. The proposed network has made following improvements compared to nnU-Net. Firstly, Space-to-depth (SPD) modules...