A5052601534- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Diverticular Disease and Complications
- Cancer, Lipids, and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Chronic Lymphocytic Leukemia Research
- Rheumatoid Arthritis Research and Therapies
- Biosimilars and Bioanalytical Methods
- Immune cells in cancer
- RNA Research and Splicing
- Radiomics and Machine Learning in Medical Imaging
- Phagocytosis and Immune Regulation
- Microscopic Colitis
- Renal cell carcinoma treatment
- MicroRNA in disease regulation
- Colorectal and Anal Carcinomas
- Stoma care and complications
- Hippo pathway signaling and YAP/TAZ
- Water-Energy-Food Nexus Studies
- Minimally Invasive Surgical Techniques
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
Lanzhou University
2020-2024
First Hospital of Lanzhou University
2020-2023
ScienceSouth
2015
Background: Hepatocellular carcinoma (HCC) is one of the highly heterogeneous cancers that lacks an effective risk model for prognosis prediction. Therefore, we searched angiogenesis-related immune genes affected HCC to construct a and studied role this in HCC. Methods: In study, collected transcriptome data from The Cancer Genome Atlas (TCGA) International Consortium (ICGC) database. Pearson correlation analysis was performed identify association between genes. Consensus clustering applied...
Background: Abnormal glucose and lipid metabolism plays a critical role in gastric carcinogenesis development. Hence, we presented systematic analysis of metabolism-related genes to explore their function prognostic value cancer (GC). Methods: The consensus clustering algorithm was used identify the molecular subtypes based on genes. Subsequently, cox regression lasso were utilized establish risk prediction model. A clinical nomogram constructed assist prognosis assessment. In addition,...
Background: Pancreatic cancer (PC) is one of the most common digestive malignancy, with severe cancer-related death and disease burden.Yes-associated protein 1 (YAP1) has been reported to be involved in tumorigenesis progression several cancers, thus leading poor prognosis patients.However, relationship between YAP1 immune microenvironment PC deserve more scrutiny.Methods: GEPIA, OncoLnc, PROGgeneV2 HPA database were utilized analyze expression (transcriptome levels) overall survival...
The global burden of hepatocellular carcinoma (HCC) is increasing, negatively impacting social health and economies. discovery novel valuable biomarkers for the early diagnosis therapeutic guidance HCC urgently needed.Extracellular matrix (ECM)-related gene sets, transcriptome data mutation profiles were downloaded from Matrisome Project Cancer Genome Atlas (TCGA)-LIHC datasets. Coexpression analysis was initially performed with aim identifying ECM-related lncRNAs (r > 0.4, p < 0.001)....
Background and Aim : Gastric cancer (GC) is the common leading cause of cancer‐related death worldwide. Immune‐related genes (IRGs) may potentially predict lymph node metastasis (LNM). We aimed to develop a preoperative model LNM based on these IRGs. Methods In this paper, we compared evaluated three machine learning models publicly available gene expression data from TCGA‐STAD. The Pearson correlation coefficient (PCC) method was utilized feature selection according its relationships with...
Background: Hepatocellular carcinoma (HCC) is a highly heterogeneous disease with the high rates of morbidity and mortality due to lack effective prognostic model for prediction. Aim: To construct risk composed epithelial–mesenchymal transition (EMT)-related immune genes assessment prognosis, infiltration status, chemosensitivity. Methods: We obtained transcriptome clinical data HCC samples from The Cancer Genome Atlas (TCGA) International Consortium (ICGC) databases. Pearson correlation...
Different matrisomal patterns are shared across carcinomas. However, little is known about whether there exists a unique tumor matrisome that modulates GC progression and immune regulation. We conducted genome-wide analysis based on matrisomal-related lncRNAs (MRLs) in 375 patients with from the Cancer Genome Atlas (TCGA) database. Patients were split into training set validation at ratio of 1:1 using R package cart. Pearson correlation (PCA) was performed to identify correlated differential...
Introduction Vegetation plays a crucial role in terrestrial ecosystems, acting as vital link connecting the lithosphere, hydrosphere, and atmosphere terms of energy flow material cycling. Changes surface vegetation significantly regulate water cycle, within surfaces, global carbon balance. Methods This study focuses on nine major river basins China to quantitatively investigate impacts climate factors, dynamics, land use changes efficiency (CUE) (WUE). Results The primary controlling factors...
N7-Methylguanosine (m7G) is an RNA modification serving as a key part of colon cancer development. Thus, comprehensive analysis was executed to explore prognostic roles and associations with the immune status m7G-related lncRNA (m7G-RNAs) in adenocarcinoma (COAD). Identification m7G-RNAs achieved via Pearson's correlation lncRNAs TCGA-COAD dataset m7G regulators. A signature developed LASSO analyses. ESTIMATE, CIBERSORT, ssGSEA algorithms were utilized assess infiltration between different...
<h3>Background</h3> Accurate measurement of disease activity is important for optimal management patients with rheumatoid arthritis (RA). Better understanding similarities and differences among the available clinical biomarker-based measures may improve their use therapeutic decision-making. <h3>Objectives</h3> Evaluate relationship between indices association other variables. <h3>Methods</h3> A cross-sectional analysis was performed 734 RA enrolled in University Pittsburgh Rheumatoid...
<abstract> <sec><title>Objective</title><p>Gastric cancer (GC) is the fifth most common malignancy and fourth leading cause of cancer-related mortality worldwide. The identification valuable predictive signatures to improve prognosis patients with GC becoming a realistic prospect. DNA damage response-related long noncoding ribonucleic acids (drlncRNAs) play an important role in development cancers. However, their prognostic therapeutic values remain sparse...
<abstract> <p>Gastric cancer (GC) is one of the most common digestive tumors in Northwest China. Previous sequencing analysis revealed that family with sequence similarity 153 member B (FAM153B) might be primary driver gene GC. In this study, we aim to explore potential roles FAM153B Microarray data were firstly obtained from public databases evaluate genetic expression between GC and normal tissues. The results verified immunohistochemistry (IHC). We also performed co-expression...