A5049599927- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Galectins and Cancer Biology
- Ferroptosis and cancer prognosis
- Renal and Vascular Pathologies
- Circular RNAs in diseases
- Delphi Technique in Research
- Renal and related cancers
- RNA Research and Splicing
- Cytomegalovirus and herpesvirus research
- Hepatitis B Virus Studies
- Myasthenia Gravis and Thymoma
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Hepatitis C virus research
- Asthma and respiratory diseases
- Renal cell carcinoma treatment
- Diabetes and associated disorders
- Signaling Pathways in Disease
- Bioinformatics and Genomic Networks
- Toxin Mechanisms and Immunotoxins
- Protein Tyrosine Phosphatases
- Immune Cell Function and Interaction
Fujian Medical University
2022
Southern Medical University
2022
Kunming University of Science and Technology
2022
First People's Hospital of Yunnan Province
2022
Lanzhou University
2022
First Hospital of Lanzhou University
2022
Amsterdam University Medical Centers
2019
Shanghai Jiao Tong University
2018
Qilu Hospital of Shandong University
2015
Yuhuangding Hospital
2009
Abstract Background Energy metabolism disorder, especially lipid is an important biological characteristic of colon cancer. This research sought to examine the association between metabolism-related long non-coding RNAs (lncRNAs) and prognoses among cancer patients. Methods The transcriptome profile clinical data patients with were retrieved from Cancer Genome Atlas database. Using consensus clustering, cases divided into two clusters Kaplan–Meier analysis was executed analyze differences in...
Abstract Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy originated from stem cells (LSC). Emerging evidence suggests T‐cell immunoglobulin mucin‐3(Tim3) as surface marker for LSC. However, the clinical significance and biology of Tim‐3 in AML remain to be determined, especially those LSCs. In public databases well our data, we separated patients into high low subsets using X‐tile software evaluated associations between overall survival (OS) disease‐free (DFS). The...
Both the T cell immunoglobulin domain- and mucin domain-containing molecule-3 (Tim-3) death receptor Fas contribute to pathogenesis of various autoimmune diseases, including systemic lupus erythematosus (SLE). The aim present study was determine whether Tim-3 are co-expressed on certain peripheral lymphocyte subsets, this expression is associated with greater disease activity in SLE.Peripheral blood mononuclear cells were isolated from 46 patients newly diagnosed SLE 28 age- sex-matched...
Clear cell renal carcinoma (ccRCC) is one of the most common tumors in urinary system. ccRCC has obvious immunological characteristics, and infiltration immune cells related to prognosis ccRCC. The effect checkpoint therapy dynamic changes tumor microenvironment (TIM). 7-methylguanosine (m7G) an additional mRNA modification ability besides m6A, which closely TIM affects occurrence development tumors. At present, correlations between m7G microenvironment, treatment, are not clear. As far as...
N7-Methylguanosine (m7G) is an RNA modification serving as a key part of colon cancer development. Thus, comprehensive analysis was executed to explore prognostic roles and associations with the immune status m7G-related lncRNA (m7G-RNAs) in adenocarcinoma (COAD). Identification m7G-RNAs achieved via Pearson's correlation lncRNAs TCGA-COAD dataset m7G regulators. A signature developed LASSO analyses. ESTIMATE, CIBERSORT, ssGSEA algorithms were utilized assess infiltration between different...
The prognosis of bladder cancer (BC) is poor, and there no effective personalized management method for BC patients at present. Developing an accurate model helpful to make treatment plan analysis patients. Endogenous fatty acid metabolism causes cells become hypoxic, the coexistence hypoxia inflammation often characteristic cancer. All three together influence tumor immune microenvironment, treatment, BC. We used Cancer Genome Atlas-Bladder Urothelial Carcinoma (TCGA-BLAC) cohorts as a...
Objective To explore the association of three single nucleotide polymorphisms (SNPs; rs228942, rs228941 and rs743777) in interleukin-2 receptor β subunit ( IL-2Rβ ) gene with susceptibility severity myasthenia gravis (MG). Methods There were 480 MG patients 487 normal controls enrolled this study, their SNPs (rs228942, IL - 2Rβ were evaluated through SNPscan TM technique. Subgroups classified by gender, age onset, anti - acetylcholine antibodies (AChR-Ab), thymus status, maximal involvement...
Objective To investigate the plasma PAF-AH level in type 1 diabetes patients and association between gene polymorphism mellitus. Methods Plasma in115 106 controls were determined by assay kit, G275A genotypes detected PCR-RLFP. Results The activity of with was significantly lower than that controls. Compared control group, frequencies GA genotype on higher T1DM group. Conclusion normal might be related to mellitus. Key words: Diabetes mellitus,typa...
Abstract Genome-wide association studies (GWAS) have identified many cancer-associated single nucleotide polymorphisms (SNP) with limited understanding of their real implication in cancer. To study the biological relevance a GWAS-discovered SNP, we performed linkage disequilibrium (LD) analysis on rs9387478 and four potentially functional SNPs. We found that SNP rs17079281 C>T was associated lung cancer 766 Chinese cases 773 matched controls, validated by another independent (558 534...
<b>Rationale:</b> Rhinovirus (RV) infections are a major driver of asthma exacerbations. Gene expression studies in rhinovirus infected asthmatic subjects have revealed differential gene-sets. Modular co-expression network analysis genes and healthy groups before after challenge is expected to reveal novel pathways networks which perturbed due viral triggers. <b>Aim:</b> To compare patterns from highly preserved modules across challenged with RV <b>Methods:</b> This follow-up study 12 10...