A5111084496- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Signaling Pathways in Disease
- Epigenetics and DNA Methylation
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Advanced Glycation End Products research
- Thyroid Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- AI in cancer detection
- Angiogenesis and VEGF in Cancer
- Galectins and Cancer Biology
- Adolescent and Pediatric Healthcare
- Renal and related cancers
- Cardiac Ischemia and Reperfusion
- Heme Oxygenase-1 and Carbon Monoxide
- S100 Proteins and Annexins
- Glioma Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Antifungal resistance and susceptibility
- Hematopoietic Stem Cell Transplantation
- Radiomics and Machine Learning in Medical Imaging
- Respiratory viral infections research
Southern Medical University
2021-2025
Zhejiang University
2025
Nanfang Hospital
2021-2025
Third Affiliated Hospital of Guangzhou Medical University
2019-2024
Guangzhou Medical University
2017-2024
Key Laboratory of Guangdong Province
2024
Foshan University
2021
This study seeks to determine the association between serum uric acid (SUA) and accelerated aging among middle-aged older adults in China, as well assess relationship SUA trajectories risk of aging. We utilized data from China Health Retirement Longitudinal Study (CHARLS), selecting participants who completed follow-ups 2011 2015. Biological age was estimated using Klemera-Doubal method, determined by calculating difference an individual's biological their chronological age. Logistic...
Abstract Background NK cells engineered to express interleukin-15 (IL-15) and a CD19-targeted chimeric antigen receptor (CAR) have been used treat patients with relapsed and/or refractory B cell malignances, demonstrating encouraging outcomes favorable safety profile. However, the effect of IL-21 in CAR-NK therapy remains unknown. Methods CD19-specific CAR 4-1BB costimulatory domain cytokine or IL-15 was constructed transduced into peripheral blood (PB)-derived produce CD19-CAR-IL21 (CAR-21)...
Background The risk of secondary primary malignancies (SPMs) associated with bispecific antibody (BsAb)—a promising alternative to chimeric antigen receptor (CAR)-T therapy—remains insufficiently explored. Methods Using large-scale, real-world data from the US Food and Drug Administration’s Adverse Event Reporting System, we identified relative frequency characteristics SPMs following BsAbs therapy conducted a comprehensive comparison treatment-related SPM profiles between CAR-T therapies....
Abstract Philadelphia chromosome (Ph)‐like acute lymphoblastic leukemia (ALL) is recognized for its genetic and clinical diversity. In this study, we identified a novel high‐risk subset of Ph‐like ALL, characterized by the activation oncogenic signaling inactivation tumor suppressor gene IKZF1 , resulting in dismal outcome. The association between cytogenetic aberrations features was assessed on cohort 191 patients with ALL. Our findings revealed that combined ( CRLF2/EPOR/JAK2...
Aims Rheumatoid arthritis (RA), which mainly results from fibroblast-like synoviocyte (FLS) dysfunction, is related to oxidative stress. Advanced oxidation protein products (AOPPs), are proinflammatory mediators and a novel biomarker of stress, have been observed accumulate significantly in the serum RA patients. Here, we present first investigation effects AOPPs on RA-FLSs signalling pathway involved AOPP-induced inflammatory responses invasive behaviour. Methods We used different...
Abstract Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy originated from stem cells (LSC). Emerging evidence suggests T‐cell immunoglobulin mucin‐3(Tim3) as surface marker for LSC. However, the clinical significance and biology of Tim‐3 in AML remain to be determined, especially those LSCs. In public databases well our data, we separated patients into high low subsets using X‐tile software evaluated associations between overall survival (OS) disease‐free (DFS). The...
Abstract The role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for adult high-risk acute lymphoblastic leukemia (HR-ALL) remained elusive in the pediatric-inspired regimen era. We conducted a cohort study on outcome allo-HSCT post-consolidation versus chemotherapy HR-ALL first complete remission PDT-ALL-2016 cohort. A total 245 patients with were enrolled, according to donor availability and patients’ preferences, among which 159 received after consolidation therapy, 86...
Abstract Background The S100 protein family is a group of small molecular EF-hand calcium-binding proteins that play critical roles in various biological processes, including promotion growth, metastasis and immune evasion tumor. However, the potential expression tumor microenvironment (TME) cell infiltration pan-cancer remain elusive. Methods Herein, we conducted comprehensive assessment patterns pan-cancer, meticulously examining their correlation with characteristics TME infiltration....
Early T-cell precursor (ETP) lymphoblastic leukemia/lymphoma is a high-risk T (T-ALL/LBL) subgroup. We performed real-world multicenter study to explore the clinical characteristics and prognosis of adolescent young adults (AYA) older adult ETP leukemia/lymphoma. A total 103 patients with ETP-ALL/LBL in five centers China between January 2016 February 2021 were included this study. The median age was 29 years (range, 15–70 years). Next-generation sequencing 94 revealed that NOTCH1 (35.1%, 33...
The prognosis of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL) patients is well established. However, the implementation dynamic MRD for risk classification and decision-making allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains vague. In this study, we collected multiparameter flow cytometry (MFC)-MRD data Ph-negative B-ALL (n = 134) from Precision-Classification-Directed-Target-Total-Therapy-ALL-2016 (PDT-ALL-2016) cohort stratified it into...
The prognostic impact of TP53 mutations (TP53mut) in adult acute lymphoblastic leukemia (ALL) remains debatable. Herein, we determined the clinical significance TP53mut 283 ALL patients treated with a pediatric-type regimen. were found 11.0% (31) patients, including 19 cases adolescent and young (AYA) 12 non-AYA patients. Patients had poorer overall survival (OS) event-free (EFS) subgroup (n = 64) (3-year OS, 18.2% vs 50.9%, p .0033; 3-year EFS, 0 45.3%, .00028). however, this to be taken...
The diagnosis of central lymph node metastasis (CLNM) is very important for the treatment papillary thyroid carcinoma (PTC), which remains highly subjective and depends on clinical experience. Traditional method based radiomics tumor feature (RTF) extraction classifications has its shortages to predict CLNM increase possibility over-diagnosis over-treatment leading PTC. In this paper, a convolutional neural network (CNN) fusion modeling proposed predictions in ultrasound-negative patients...
Summary The dysregulation of the Janus family tyrosine kinase‐signal transducer and activator transcription (JAK‐STAT) is closely related to acute lymphoblastic leukaemia (ALL), whereas clinical value phosphorylated STAT5 (pSTAT5) remains elusive. Herein we performed a prospective study on significance flow cytometry‐based pSTAT5 in adult B‐ALL patients. A total 184 patients were enrolled Precision‐Classification‐Directed‐Target‐Total‐Therapy (PDT)‐ALL‐2016 cohort between January 2018...
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Background: Although CD19-directed chimeric antigen receptor T-cell therapy (CAR-T) has emerged as one of the promising therapeutic approaches to relapsed and/or refractory B-cell acute lymphoblastic leukemia (r/r B-ALL), more than half recipients will ultimately experience disease progression. Mounting evidence shows that resistance CAR-T influenced by factors not only related effector cells, but target cells. Previous studies have shown poor outcome conferred IKZF1 deletions, been explored...