A5100362282- Cancer Immunotherapy and Biomarkers
- PARP inhibition in cancer therapy
- Ferroptosis and cancer prognosis
- Cutaneous Melanoma Detection and Management
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- AI in cancer detection
- Drug Transport and Resistance Mechanisms
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Cancer survivorship and care
- HER2/EGFR in Cancer Research
- CAR-T cell therapy research
- Genetic factors in colorectal cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer therapeutics and mechanisms
- Lung Cancer Treatments and Mutations
- Melanoma and MAPK Pathways
- Lipid metabolism and disorders
- Digital Media Forensic Detection
- Cancer Cells and Metastasis
- Clusterin in disease pathology
- Pancreatitis Pathology and Treatment
- Remote Sensing and Land Use
- Microtubule and mitosis dynamics
Southern Medical University
2023-2025
Nanfang Hospital
2023-2025
Nanjing University of Chinese Medicine
2023-2025
Nanchang University
2022-2024
Princess Margaret Cancer Centre
2021-2024
Qiqihar University
2024
Institute of Hematology & Blood Diseases Hospital
2023-2024
Second Affiliated Hospital of Nanchang University
2022-2024
Liaoning Provincial People's Hospital
2024
China GreatWall Technology Group (China)
2023
Abstract Recently, deep learning has achieved considerable results in the hyperspectral image (HSI) classification. However, most available networks require ample and authentic samples to better train models, which is expensive inefficient practical tasks. Existing few‐shot (FSL) methods generally ignore potential relationships between non‐local spatial that would represent underlying features of HSI. To solve above issues, a novel transformer (DT‐FSL) classification framework proposed,...
Background Despite great success, immunotherapy still faces many challenges in practical applications. It was previously found that family with sequence similarity 110 member A (FAM110A) participate the regulation of cell cycle and plays an oncogenic role pancreatic cancer. However, prognostic value FAM110A pan-cancer its involvement immune response remain unclear. Methods The Human Protein Atlas (HPA) database used to detect expression human normal tissues, Tumor Immune Estimation Resource...
CD19 chimeric antigen receptor (CAR) engineered NK cells have been used for treating patients with relapsed and/or refractory B cell malignancies and show encouraging outcomes safety profile. However, the poor persistence of remains a major challenge CAR therapy. Memory-like (MLNK) induced by IL-12, IL-15, IL-18 shown enhanced prolonged responses to tumor re-stimulation, making them an attractive candidate adoptive cellular immunotherapy. Here, we efficient stable gene delivery memory-like...
Colorectal cancer (CRC) is the third most prevalent form of worldwide. Among patients with CRC, colorectal liver metastasis (CRLM) foremost direct contributor to mortality. In recent years, immunotherapy has swiftly risen prominence as a vital approach for treating range solid tumors, including CRC. We present unique case patient suffering from CRLM, goal offering an insightful example and relevant references treatment CRLM. report who experienced after undergoing successful surgical removal...
The annual rise in gastrointestinal cancer cases is evident, yet the occurrence of multiple primary malignancies remains comparatively uncommon. In recent years, immunotherapy has swiftly emerged as leading treatment for several solid tumors, including cancers. Single treatments might be ineffective, necessitating need comprehensive integrative medicine. This study reports a case cancers, colorectal and gastric Diverse systemic treatments, like capecitabine, combination capecitabine...
Abstract Background NK cells engineered to express interleukin-15 (IL-15) and a CD19-targeted chimeric antigen receptor (CAR) have been used treat patients with relapsed and/or refractory B cell malignances, demonstrating encouraging outcomes favorable safety profile. However, the effect of IL-21 in CAR-NK therapy remains unknown. Methods CD19-specific CAR 4-1BB costimulatory domain cytokine or IL-15 was constructed transduced into peripheral blood (PB)-derived produce CD19-CAR-IL21 (CAR-21)...
In recent years, homologous recombination deficiency (HRD) has not achieved the expected substantial promotion of immunotherapeutic efficacy in ovarian cancer.This study aims to explore role HRD functional phenotype as a powerful biomarker identifying patients who may benefit from immunotherapy.HRD phenotype, namely HRD-EXCUTE, was defined average level 15 hub genes upregulated cancer.A decision tree plotted evaluate critical HRD-EXCUTE patients.Agents inducing were identified by CMAP web...
The aim of the study was to investigate changes in serum glypican 4 (GPC4) and clusterin (CLU) levels patients with polycystic ovary syndrome (PCOS) as well their correlation sex hormones metabolic parameters. A total 40 PCOS age-matched healthy women were selected. Serum GPC4 CLU compared between control groups, binary logistic regression used analyze relative risk at different tertiles concentrations. Stepwise linear identify factors influencing patients. (1.82 ± 0.49 vs 1.30 0.61 ng/mL, P...
Deep learning methods have shown outstanding potential in dermatology for skin lesion detection and identification. However, they usually require annotations beforehand can only classify classes seen the training set. Moreover, large-scale, open-sourced medical datasets normally far fewer annotated than real life, further aggravating problem. This paper proposes a novel method called DNF-OOD, which applies non-parametric deep forest-based approach to problem of out-of-distribution (OOD)...
A series of C2-modified 10-deacetyl-7-propionyl cephalomannine derivatives was designed, prepared, and biologically evaluated. Some C2 meta-substituted benzoate analogues showed potent activity against both drug-sensitive drug-resistant tumor cells in which resistance is mediated through either P-gp overexpression or beta-tubulin mutation mechanisms. The taxoid 15 b related compounds are particular interest, as they much more cytotoxic than paclitaxel, especially cells; able to kill (low R/S...
Background: Small cell lung cancer (SCLC) represents about 13% of cases, which is highly invasive and has a high mortality rate, with the 5-year overall survival (OS) rate being only 6.3%.Age at diagnosis advanced SCLC much older, but studies describing ageing factor for distant metastasis patterns prognosis extensive-stage (ES-SCLC) are limited.Methods: Using Surveillance, Epidemiology, End Results (SEER) registry, we identified 18,682 patients ES-SCLC (9,089 women 9,053 men) who had...
Pro-inflammatory cytokines induced by succinate blocked the activation of FXR and its target genes disturbed bile acid enterohepatic circulation.
The purpose of this study was to investigate the prognostic significance like-Sm (LSM) genes in early pancreatic ductal adenocarcinoma (PDAC) and explore potential molecular mechanism. protein product LSM1 gene is also known as CASM YJL124C, while that LSM4 GRP YER112W.Data from 112 patients attached Whipple surgery were collected TCGA database clinical characteristics survival data. Kaplan-Meier method multivariate Cox proportional risk regression model used analyze impact LSM on outcomes...
Background: The risk factors for acute care utilization in gynecologic oncology patients are poorly understood. This study aimed to evaluate the of our centre’s radiation nursing clinic (RNC) by receiving radiotherapy (RT). Methods: was a retrospective cohort gynecological cancer treated with RT at an academic centre between 1 August 2021 and 31 January 2022. Data on socio-demographics, clinical treatment characteristics, RNC visits were collected summarized descriptive statistics. Wilcoxon...
Pediatric acute myeloid leukemia (pAML) is a clonal disease with recurrent genetic alterations that affect epigenetic states. However, the implications of dysregulation in progression remain unclear. Here, we interrogated single-cell and level chromatin accessibility bone marrow samples from 28 pAML patients representing multiple subtypes using mtscATAC-seq, which revealed distinct differentiation hierarchies abnormal subtype-specific manner. Innate immune signaling was commonly enhanced...