A5064633982- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Genomics, phytochemicals, and oxidative stress
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- PI3K/AKT/mTOR signaling in cancer
- Hepatitis B Virus Studies
- Hematopoietic Stem Cell Transplantation
- Vascular Malformations and Hemangiomas
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- FOXO transcription factor regulation
- Inflammatory Biomarkers in Disease Prognosis
- Immune cells in cancer
- Transition Metal Oxide Nanomaterials
- Blood groups and transfusion
- Developmental Biology and Gene Regulation
- Multiple and Secondary Primary Cancers
- Esophageal Cancer Research and Treatment
- Galectins and Cancer Biology
First Affiliated Hospital of GuangXi Medical University
2020-2025
Guangxi Medical University
2020-2025
Yichang Central People's Hospital
2025
China Three Gorges University
2025
Sun Yat-sen University
2024-2025
Eighth Affiliated Hospital of Sun Yat-sen University
2024-2025
Ruijin Hospital
2023
Shanghai Jiao Tong University
2023
Shanghai Institute of Hematology
2023
Guangxi Center for Disease Prevention and Control
2023
Hepatocellular carcinoma (HCC) is the leading cause of cancer death. Kinesin family member 2C (KIF2C) has been shown as oncogene in a variety tumors. However, its role HCC remains unclear.In this study, expression level KIF2C was detected by immunohistochemical staining and RT-PCR, verified Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA) Oncomine database. A curve established to evaluate diagnostic efficiency KIF2C. effect on investigated flow cytometry, Cell Counting Kit-8,...
Whether there is gender disparity in the recurrence of hepatocellular carcinoma (HCC) has been not fully addressed. This study aimed to investigate impact on HCC following curative hepatectomy.This retrospective cohort included 1087 patients with (917 males, 170 females) who underwent hepatectomy. Cox regression models were constructed estimate hazard ratio (HR) and 95% confidence interval (CI) risk parameters associated recurrence. In sensitivity analysis, subgroup propensity score matching...
Portal hypertension (PHT) is an important factor leading to a poor prognosis in patients with hepatocellular carcinoma (HCC). Identifying PHT for individualized treatment of great clinical significance. The prediction model HCC combined urgent need practice. Combining parameters and imaging features can improve accuracy. application artificial intelligence algorithms further tap the potential data, optimize model, provide strong support early intervention personalized PHT. This study aimed...
It has been reported that atractylodin a potential antitumor effect. This study aimed to investigate the effects of on Huh7 and Hccm hepatocellular carcinoma (HCC) cells its molecular mechanism.Huh7 were cultured in vitro, their viability was detected by CCK-8 assay half inhibitory concentration (IC50) calculated. The treated with different concentrations atractylodin, migration invasion ability scratch Transwell assay. cell cycle change apoptosis rate flow cytometry. IlluminaHiSeq4000...
Abstract Dual-phenotype hepatocellular carcinoma (DPHCC) is a new subtype of (HCC). This study aimed to investigate the relationship between computerized tomography scan (CT) imaging and clinicopathologic features DPHCC. The CT data 97 HCC cases who underwent radical resection were collected retrospectively. feature was evaluated by ratio average value tumor liver (TLR) in plain scan, arterial, portal vein delayed phases. association analyzed using t -test or chi-square test. Univariate...
The solute carrier (SLC) 7 family genes play central roles in cancer cell metabolism as glucose and glutamate transporters. However, their expression prognostic value breast (BC) remains to be elucidated.Clinical data from BC patients were downloaded Cancer Genome Atlas (TCGA) the Kaplan-Meier (KM) plotter database. mechanisms underlying association between SLC7A overall survival (OS) explored using Cox regression log-rank tests. ESTIMATE gives a measure of immune-cell infiltrates....
Breast cancer (BC) is the most common type of affecting females. It also a leading cause cancer-related death in women worldwide.Sonodynamic therapy (SDT) an emerging therapeutic strategy for treatment. SDT ensures non-invasive penetration deep tumors and results activation non-toxic sonosensitizers administered tumor sites to become cytotoxic. has been reported that 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD) significant anti-tumor effect against various types including BC....
Abstract Leucocyte immunoglobulin‐like receptors (LILRs) are closely related to tumourigenesis, but their clinical value in early‐stage pancreatic ductal adenocarcinoma (PDAC) after pancreaticoduodenectomy remains unknown. Kaplan–Meier and Cox proportional hazards regression models is used investigate the association between LILR expression prognosis tumour biopsies peripheral blood mononuclear cells. Risk score was calculated for each patient based on prognostic model. DAVID, STRING,...
Background: The protein high-mobility group AT-hook 1 (HMGA1) has been demonstrated that modulated cellular proliferation, invasion, and apoptosis with a poor prognosis in miscellaneous carcinomas. However, the mechanism of circumstantial carcinogenesis association immune microenvironment HMGA1 hepatocellular carcinoma (HCC) had not extensively explored. Methods: gene expression, clinicopathological correlation, analysis were performed data obtained from TCGA. results further validated by...
The purpose of this study was to investigate the prognostic significance like-Sm (LSM) genes in early pancreatic ductal adenocarcinoma (PDAC) and explore potential molecular mechanism. protein product LSM1 gene is also known as CASM YJL124C, while that LSM4 GRP YER112W.Data from 112 patients attached Whipple surgery were collected TCGA database clinical characteristics survival data. Kaplan-Meier method multivariate Cox proportional risk regression model used analyze impact LSM on outcomes...
The aim of this study was to determine the relationship between tumor mutation burden (TMB) and prognosis patients with hepatocellular carcinoma (HCC), explore differential expression genes in HCC by TMB immune cells, TMB, HCC.Somatic variation data, gene transcriptional data clinical information were obtained from cancer genome map (TCGA) database. Analyze characteristics sample, divide high low groups draw survival curve at same time, carry on difference analysis further univariate Cox...
PDRG1 are involved in various physiological regulations of cells, include cell proliferation, growth, apoptosis and cycle regulation, but their roles cancer have not been clearly studied.Firstly, we evaluated the expression prognostic significance using a pan-cancer analysis The Cancer Genome Atlas (TCGA) Genotypic Tissue Expression (GTEx) databases. Secondly, correlations between immune m6A methylation, tumor mutation burden (TMB), microsatellite instability (MSI) were investigated....
Background: Cytokeratin 19 (CK19/KRT19) is a marker of biliary epithelial cells and hepatic progenitor cells, which can be expressed in some hepatocellular carcinoma (HCC). However, its role the occurrence, development, recurrence hepatitis B virus (HBV)-associated HCC remains to clarified. This study analyze relationship between expression CK19 protein clinicopathological factors, as well effect positive on prognosis patients. Methods: Small interfering RNA (siRNA) transfection was used...
The relationship between ABO blood group and prognosis of patients with hepatocellular carcinoma (HCC) remains unclear. We investigated the in hepatitis B-associated HCC after radical hepatectomy.The medical records 874 who underwent liver tumor resection were retrospectively collected. Cox proportional risk models constructed for analysis, patient data further balanced using propensity score matching (PSM) analysis to assess impact on HCC.In univariate regression overall survival (OS) non-A...
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD) has been reported to have good antitumor effects. The aim of this study was investigate whether DMDD induces apoptosis and autophagy in human cholangiocarcinoma (CCA) QBC939 cells determine its effect on the PI3K/AKT/mTOR signaling pathway.QBC939 were cultured vitro changes cell viability detected by Cell Counting Kit (CCK8) assay after treatment with different concentrations for 24, 48, 72 h. divided into control DMDD-treated groups...
Early stage hepatocellular carcinoma (HCC) has a high recurrence rate after surgery and lacks reliable predictive tools. We explored the potential of combining enhanced CT with gut microbiome to develop model for early HCC surgery. A total 112 patients who underwent hepatectomy from September 2018 December 2020 were included in this study, machine learning method was divided into training group (N = 71) test 41) observed endpoint recurrence-free survival (RFS). Features extracted arterial...
The effect of time delay from diagnosis to surgery on the prognosis elderly patients with liver cancer is not well known. We investigated surgical timing hepatocellular carcinoma undergoing resection and constructed a Nomogram model predict overall survival patients.
The formation of portal vein tumor thrombus (PVTT) is closely related to the prognosis patients with hepatocellular carcinoma (HCC). However, mechanisms by which PVTTs form and biomarkers involved are still little understood.The Genome Expression Omnibus (GEO) Cancer Atlas (TCGA) databases were used obtain transcriptome data from normal tissue, HCC primary tumors (PTs) HCC, paired PVTT tissue. Differentially expressed genes (DEGs) in PTs analyzed. differentially immune further investigated...
<title>Abstract</title> Background Hepatocellular carcinoma (HCC) is a common malignant digestive tract tumor worldwide. Disulfidptosis and entosis are two special cell death mechanisms. The purpose of this study was to investigate the prognostic clinical applicability these death-related genes in HCC. Methods R package "Deseq2" used conduct differential expression analysis, 22 disulfidptosis-related 25 entosis-related were screened out 15 genes, 8 key subsequently by single-factor Cox...
Several studies have suggested a potential antitumor effect of 2‐dodecyl‐6‐methoxycyclohexa‐2,5‐diene‐1,4‐dione (DMDD). To further understand the mechanism action this compound, we investigated its on phosphatidylinositol‐3‐kinase (PI3K)/serine–threonine kinase (Akt)/mammalian target rapamycin (mTOR) signaling pathway. We show that DMDD application significantly inhibited proliferation breast cancer cell lines MDA‐MB‐231 and ER‐α positive MCF‐7. Furthermore, resulted in increased...