A5090531718- Cardiac Fibrosis and Remodeling
- Autophagy in Disease and Therapy
- Viral Infections and Immunology Research
- Cancer, Lipids, and Metabolism
- Microtubule and mitosis dynamics
- Cardiovascular Function and Risk Factors
- Cell Adhesion Molecules Research
- Pharmacological Effects of Natural Compounds
- Nanoparticle-Based Drug Delivery
- Gut microbiota and health
- Cancer Genomics and Diagnostics
- Melanoma and MAPK Pathways
- Traditional Chinese Medicine Analysis
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Protein Tyrosine Phosphatases
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Cardiomyopathy and Myosin Studies
First Affiliated Hospital of GuangXi Medical University
2023-2025
Guangxi Medical University
2021-2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2019-2022
First Hospital of Jiaxing
2020-2021
Tianjin University of Traditional Chinese Medicine
2018
Background: MATN3 is a member of the matrix protein family and involved in regulation osteoarthritis as well development gastric cancer. We investigated role pan-cancer validated this result by vitro experiments. Material Methods: applied multiple databases to explore expression 33 types tumors. Kaplan-Meier survival analysis performed understand effect on Prognostic value patients with different cancer types. The TIMER database was relationship between immune checkpoint genes,...
It has been reported that atractylodin a potential antitumor effect. This study aimed to investigate the effects of on Huh7 and Hccm hepatocellular carcinoma (HCC) cells its molecular mechanism.Huh7 were cultured in vitro, their viability was detected by CCK-8 assay half inhibitory concentration (IC50) calculated. The treated with different concentrations atractylodin, migration invasion ability scratch Transwell assay. cell cycle change apoptosis rate flow cytometry. IlluminaHiSeq4000...
QiShenYiQi pill (QSYQ), a traditional Chinese medicine, is used to treat cardiovascular diseases. However, the dose-effect relationship of its intervention in reactive myocardial fibrosis elusive. In this work, rat models induced by partial abdominal aortic coarctation were constructed and randomly classified into model group, 3-methyladenine rapamycin QSYQ low-dose medium-dose high-dose sham-operated rats (control group). We revealed that lowered heart mass index (HMI), left ventricular...
Abstract QiShenYiQi pill (QSYQ), a traditional Chinese medicine, is well known for improving the myocardial remodelling, but dose‐effect relationship of its intervention in reparative fibrosis still unclear. We investigated effect QSYQ on cardiac myosin‐induced rats and explored mechanism action by regulating autophagy. The results indicated that increased LVEF LVFS, decreased LVEDD, LVESD, HMI, LVMI, inflammation histology score, collagen volume fraction dose‐dependent manner. In addition,...
Context QiShenYiQi pill (QSYQ) is a traditional Chinese medicine with myocardial protective effect.Objective To explore the effect of QSYQ on collagen metabolism in rats autoimmune cardiomyopathy and underlying mechanism from aspect apoptosis.Materials methods We established an model using Lewis rats. The were then randomly divided into six groups (n = 8): control, model, 3-methyladenine (15 mg/kg, intraperitoneal injection), low-dose (135 gavage), medium dose (270 high-dose (540 gavage) for...
Introduction: This study implies the enhancement of apatinib killing effect in 4T1 tumor cells through constructing drug-loaded nanoparticles apatinib/Ce6@ZIF-8@Membranes (aCZM) to enhance therapeutic targeting and reduce toxic side following sonodynamic therapy (SDT). Methods: apatinib/Ce6@ZIF-8 (aCZ) were synthesized by situ encapsulation, aCZM constructed encapsulating with extracted breast cancer cell membranes. characterized tested for stability electron microscopy, membrane proteins on...
In the treatment of unresectable advanced hepatocellular carcinoma (HCC), cisplatin is administered transhepatic arterially for local treatment, but clinical application drugs frequently hindered by emergence drug resistance. Kinesin family member 2C( KIF2C ) has been shown as oncogene in a variety tumors. Nevertheless, its effect on sensitivity yet to be ascertained. Herein, we aim investigate impact gene within HCC and plausible underlying molecular mechanism. We examined expression level...