A5100412104- Glioma Diagnosis and Treatment
- Amyotrophic Lateral Sclerosis Research
- Radiomics and Machine Learning in Medical Imaging
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Advanced Neuroimaging Techniques and Applications
- Chronic Lymphocytic Leukemia Research
- Neurological diseases and metabolism
- RNA modifications and cancer
- MRI in cancer diagnosis
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Lymphoma Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Fibroblast Growth Factor Research
- Cancer Research and Treatments
- biodegradable polymer synthesis and properties
- Functional Brain Connectivity Studies
- Mesenchymal stem cell research
- Connective Tissue Growth Factor Research
- Histone Deacetylase Inhibitors Research
Qilu Hospital of Shandong University
2024-2025
South China University of Technology
2024
Guangzhou Medical University
2024
Guangzhou First People's Hospital
2024
Jiangsu University
2024
Affiliated Hospital of Jiangsu University
2024
First Affiliated Hospital of Zhengzhou University
2020-2023
First Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Southwest Hospital
2023
To develop and validate a deep learning signature (DLS) from diffusion tensor imaging (DTI) for predicting overall survival in patients with infiltrative gliomas, to investigate the biological pathways underlying developed DLS.
Mutations in isocitrate dehydrogenase (IDH), a key enzyme the tricarboxylic acid cycle, have recently been found ~75% glioma and ~20% acute myeloid leukemia. Different from wild-type enzyme, mutant IDH1 catalyzes reduction of α-ketoglutaric to D-2-hydroxyglutaric acid. Strong evidence has shown represents novel target for this type cancer. We two 1-hydroxypyridin-2-one compounds that are potent inhibitors R132H R132C mutants with Ki values as low 120 nM. These exhibit >60-fold selectivity...
The 2016 WHO classification of central nervous system tumors has included four molecular subgroups under medulloblastoma (MB) as sonic hedgehog (SHH), wingless (WNT), Grade 3, and Group 4. We aimed to develop machine learning models for predicting MB based on multi-parameter magnetic resonance imaging (MRI) radiomics, tumor locations, clinical factors. A total 122 patients were enrolled retrospectively. After selecting robust, non-redundant, relevant features from 5,529 extracted radiomics...
Isocitrate dehydrogenase (IDH) mutation and 1p19q codeletion status have been identified as significant markers for therapy prognosis in lower-grade glioma (LGG). The current study aimed to construct a combined machine learning-based model predicting the molecular subtypes of LGG, including (1) IDH wild-type astrocytoma (IDHwt), (2) mutant non-codeleted (IDHmut-noncodel), (3) IDH-mutant codeleted oligodendroglioma (IDHmut-codel), based on multiparametric magnetic resonance imaging (MRI)...
Type 2 diabetes mellitus is accompanied by cognitive impairment and associated with an increased risk of dementia. Damage to brain structures such as white matter network disruption may underlie this disturbance. In the present study, 886 non-diabetic 163 type diabetic participan ts completed a battery neuropsychological tests. Among them, 38 patients 34 participants that matched for age/sex/education received magnetic resonance imaging-based diffusion tensor imaging. Then we calculated...
To date, conflicting results about the role of vitamins in amyotrophic lateral sclerosis (ALS) have been reported along with a lack systematic studies on all types serum patients ALS. Moreover, extensive conducted other neurodegenerative diseases; however, whether vitamin alterations ALS are similar to those diseases remains unclear. Therefore, we performed study involving large Chinese cohort address this gap. In study, 202 ALS, 214 disease that mimicked (mimics), and 208 healthy controls...
Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease that affects neurons in the central nervous system and spinal cord. As many other disorders, genetic risk factors pathogenesis of ALS involve dysregulation cytoskeleton neuronal transport. Notably, sensory motor neuron diseases such as hereditary autonomic neuropathy type 2 (HSAN2) spastic paraplegia 30 (SPG30) share several causative genes with ALS, well having common clinical phenotypes. KIF1A...
In Brief Study Design. A multicenter cross-cultural study to re-evaluate the reliability and validity of simplified Chinese version Scoliosis Research Society-22 (SRS-22) Patient Questionnaire. Objective. To assess concurrent this instrument in mainland China. Summary Background Data. The SRS-22 Questionnaire was developed health-related quality life for patients with scoliosis United States. More recently, analyses traditional versions questionnaire were performed, respectively. However,...
Differentiated thyroid carcinoma (DTC) accounts for the vast majority of cancer (TC) cases. The rapidly increasing incidence TC requires urgent identification new diagnostic and therapeutic targets. Solute carrier family 27 member 2 (SLC27A2/FATP2) plays an essential role in lipid biosynthesis fatty acid transport. Recent studies have confirmed its involvement a variety diseases, including cancer.In this study, expression SLC27A2 was analyzed paracancerous tissue samples from 98 patients, we...
Abstract Background We aimed to develop machine learning models for prediction of molecular subgroups (low-risk group and intermediate/high-risk group) marker ( KIAA1549-BRAF fusion) pediatric low-grade gliomas (PLGGs) based on radiomic features extracted from multiparametric MRI. Methods 61 patients with PLGGs were included in this retrospective study, which divided into a training set an internal validation at ratio 2:1 the or marker. The classified low-risk groups, BRAF fusion positive...
The apolipoprotein E (APOE) ɛ4 allele is the strongest genetic risk factor for Alzheimer's disease (AD). This study aimed to investigate abnormality of white matter integrity and its relationship cognitive impairments in Chinese non-demented elderly with without allele. We assessed differences using a series neuropsychological tests tract-based spatial statistics measure mean diffusivity fractional anisotropy. determined that there were no statistically significant group any measures....
Background Glioma is the most common cancer of central nervous system with poor therapeutic response and clinical prognosis. Insulin-like growth factor 1 receptor ( IGF-1R ) signaling implicated in tumor development progression induces apoptosis cells following functional inhibition. However, relationship between -related pathway genes glioma prognosis or immunotherapy/chemotherapy poorly understood. Methods LASSO–Cox regression was employed to develop a 16-gene risk signature TCGA-GBMLGG...
Polymorphisms of the apolipoprotein E (APOE) promoter rs405509 are related to Alzheimer's disease (AD). The T/T allele decreases transcription APOE gene and leads impairments in a specific brain structural network aged individuals; thus, it is an important risk factor f or AD. However, remains unknown whether affects white matter networks during aging. Here, we investigated effect genotype (T/T versus G-allele) on age-related via construction graph theory-based connectome using diffusion MRI...