A5046668292- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- Advanced Photocatalysis Techniques
- Immunotherapy and Immune Responses
- Adsorption and biosorption for pollutant removal
- Galectins and Cancer Biology
- Allergic Rhinitis and Sensitization
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Signaling Pathways in Disease
- Viral gastroenteritis research and epidemiology
- HIV Research and Treatment
- T-cell and B-cell Immunology
- Nanomaterials for catalytic reactions
- Dye analysis and toxicity
- Oral Health Pathology and Treatment
- Vector-borne infectious diseases
- Immune cells in cancer
- Inflammasome and immune disorders
- Vector-Borne Animal Diseases
- Insect and Pesticide Research
- Supercapacitor Materials and Fabrication
- Nanoporous metals and alloys
Wenzhou Medical University
2020-2025
Lishui University
2025
Zhejiang University
2025
Qilu Hospital of Shandong University
2024-2025
Lanzhou Jiaotong University
2024-2025
Shaanxi University of Science and Technology
2021-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2020-2024
Second Affiliated Hospital of Zhengzhou University
2019-2024
Arthritis and Rheumatism Associates
2024
Jiangxi Agricultural University
2024
An increasing amount of research has indicated obesity greatly affects individuals with overactive bladder (OAB). However, traditional anthropometric methods present challenges in accurately assessing the likelihood OAB. Hence, this study's objective was to identify correlation between body roundness index (BRI) and
Overexpression of serine protease inhibitor Kazal type 1 (SPINK1) defines an aggressive molecular subtype ETS fusion-negative prostate cancer (PCa) patients in western countries. However, how SPINK1 contributes to PCa invasion and metastasis is largely unknown.Fluorescence situ hybridization immunohistochemistry were utilized detect ERG rearrangement, expression, EGFR aberrations a cohort 211 with radical prostatectomy. Real-time quantitative PCR Western blotting used study the transcript...
Multiple negative regulators restrict the ability of T cells to attack tumors. This work demonstrates role PI3K-interacting protein 1 (Pik3ip1) in restraining T-cell responses and antitumor immunity.An anti-Pik3ip1 mAb was generated identify Pik3ip1 expression pattern hematopoietic cells. Pik3ip1-/- mice a fusion were investigate effect on T-cell-mediated immunity MC38 B16-F10 tumor models. Immunoblotting confocal microscopy used inhibitory effects receptor (TCR) signaling. quantified, its...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) continue to wreak havoc across the globe. Higher transmissibility and immunologic resistance VOCs bring unprecedented challenges epidemic extinguishment. Here we describe a monoclonal antibody, 2G1, that neutralizes all current has surprising tolerance mutations adjacent or within its interaction epitope. Cryo-electron microscopy structure showed 2G1 bound tip receptor binding domain (RBD) spike protein...
Luminescent lanthanide compounds stand out for their distinctive characteristics including narrow emission bands, substantial Stokes shifts, high quantum yields, and unique luminescent colors. However, Ln3+ is highly susceptible to vibrational quenching from X–H (X = O/N) high-energy oscillators in the embedded organic antenna, resulting significant nonradiative energy dissipation of 5D excited states Ln3+. Herein, we introduce a strategy based on supramolecular interactions modulate...
Abstract Background Radiofrequency ablation (RFA) is an efficient treatment with unlimited potential for liver cancer that can effectively reduce patient mortality. Understanding the biological process related RFA important improving strategy. This study aimed to identify critical targets regulating efficacy of RFA. Methods The in hepatocellular carcinoma (HCC) tumor models vivo, was analyzed by RNA sequencing technology. heat vitro HCC cells also constructed explore mechanism after cells....
The rapid evolution of the viral genome has led to continual generation new variants SARS-CoV-2. Developing antibody drugs with broad-spectrum and high efficiency is a long-term task. It promising but challenging develop therapeutic neutralizing antibodies (nAbs) through in vitro based on antigen–antibody binding interactions. From an early B cell repertoire, we isolated 8G3 that retains its nonregressive activity against Omicron BA.1 various other strains vitro. protected ACE2 transgenic...
Carcinogen Cr(VI) is reduced efficiently into Cr(III) by a photocatalyst, but the produced difficult to transfer from photocatalytic active site. The "two birds with one stone" strategy proposed realize in situ growth of ZnIn2S4 nanoplates on SBA-15 and creation separated sites, which ZnO loading porous nanorod was used as zinc source. Obtained samples ZnIn2S4/SBA-15 (ZIS/SBA) showed redshift absorption band better separation photoinduced carriers than pristine ZnIn2S4, due its smaller size...
This study was undertaken to develop and validate a radiomics model based on multiparametric magnetic resonance imaging (MRI) for predicting recurrence in patients with hepatocellular carcinoma (HCC) following postoperative adjuvant transarterial chemoembolization (PA-TACE). In this retrospective study, 149 HCC (81 training, 36 internal validation, 32 external validation) treated PA-TACE were included two medical centers. Multiparametric features extracted from three MRI sequences. Least...
Forkhead Box P3 (Foxp3) is a regulatory T cells marker, and its expression correlates with prognosis in number of malignancies. The aim this study to determine the relationship Foxp3 clinicopathological parameters oral squamous cell carcinoma (OSCC). was examined using immunohistochemistry (IHC) paraffin-embedded tissue samples from 273 OSCC patients. Statistical analysis performed evaluate associations between expression, clinicopathologic characteristics prognostic factors OSCC. protein...
B and T lymphocyte attenuator (BTLA) is a co-signaling protein belonging to the CD28 immunoglobulin superfamily. However, role of BTLA in prognosis immunotherapy colorectal cancer (CRC) remains unclear. We evaluated expression via Oncomine genome atlas (TCGA) database. research outcome among different patients by Kaplan-Meier curve. used Chi-Squared test Cox regression analysis identify potential risk factors. Besides, correlations between immune infiltration were investigated CIBERSORT....
Papillary thyroid cancer (PTC) is the most common malignancy of endocrine system, with an increase in incidence frequency. Major vault protein (
Over 95% of CD4 cell death occurs by Caspase-1-mediated pyroptosis during HIV infection. Caspase-3-mediated apoptosis accounts for the in a small proportion infected cells. To date, there have been no reports on dynamics Caspase-1 and Caspase-3 their relationship with disease progression acute HIV-1 In this study, two distinct patient groups were enrolled. The CD4High group maintained level above450 cells/μl while levels CD4Low dropped below 250 within 2 years after Blood samples collected...
Li1.6Mn1.6O4 (LMO) synthesized by microwave assisted hydrothermal method were used to obtain MnO2·0.5H2O ion sieves (HMO) after acid treatment. The HMO-1 prepared with a Li/Mn molar ratio of 4, at 100ºC for 1 h under irradiation, exhibits an effective Li+ adsorption capacity 5.6 mmol·g−1 and high selectivity equilibrium distribution coefficient 12366.44 mL·g−1. Moreover, it shows almost saturated ion-exchange (> 95%) extracted/inserted process. Thus HMO ion-sieves are expected be promising...
Elucidation of the mechanisms T-cell-mediated antitumor responses will provide information for rational design and development cancer immunotherapies. Here, we found that calnexin, an endoplasmic reticulum (ER) chaperone protein, is significantly upregulated in oral squamous cell carcinoma (OSCC). Upregulation its membranous expression on OSCC cells associated with inhibited T-cell infiltration tumor tissues correlates poor survival patients OSCC. We calnexin inhibits proliferation CD4+ CD8+...
Abstract The YMnO 3 , NiO, and NiO/YMnO nanocomposites are successfully prepared by a polyacrylamide gel method simple two phase recombination route. structure, surface morphology, optical, magnetic electrochemical properties photocatalytic activity of as-prepared samples were measured X-ray diffraction (XRD), Scanning electron microscope (SEM), UV-visible spectrophotometer, superconducting quantum interference device (SQUID), workstation 721 spectrophotometer. Phase structure analysis...