A5027956387- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Thyroid Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Mosquito-borne diseases and control
- Bone Metabolism and Diseases
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Viral Infections and Vectors
- Toxic Organic Pollutants Impact
- Oral microbiology and periodontitis research
- Infectious Diseases and Tuberculosis
- Palliative Care and End-of-Life Issues
- Flavonoids in Medical Research
- Bladder and Urothelial Cancer Treatments
- Traditional Chinese Medicine Studies
- Dental Health and Care Utilization
- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- AI in cancer detection
- Effects and risks of endocrine disrupting chemicals
- Toxin Mechanisms and Immunotoxins
- Biomarkers in Disease Mechanisms
- Chemical Analysis and Environmental Impact
Zhejiang University
2023-2025
Shaoxing People's Hospital
2025
Xintai People's Hospital
2025
North China University of Science and Technology
2014-2024
Anhui Medical University
2023
First Affiliated Hospital of Wenzhou Medical University
2021-2022
Wenzhou Medical University
2021-2022
Communication University of China
2015
National Institute for Viral Disease Control and Prevention
2011-2014
Kunming Medical University
2010
To explore the forewarning immunological indicators during periodontal attachment loss progression in American adults.A total of 5744 participants with were enrolled from National Health and Nutrition Examination Surveys (NHANES) 2009-2014. In which, dependent variable was counts teeth severe (depth probing above 5 mm). Independent variables circulatory indexes, including white blood cells (WBC), Lymphocytes, Monocytes, Neutrophils, Eosinophils, Basophils. The association among examined...
Abstract Background The incidence of dengue, an infectious disease caused by dengue virus (DENV), has dramatically increased around the world in recent decades and is becoming a severe public health threat. However, there currently no specific treatment for fever, licensed vaccine against not available. Vaccination with virus-like particles (VLPs) shown considerable promise many viral diseases, but effect DENV VLPs to induce immune responses been adequately investigated. Results By...
Abstract Breast cancer (BC) threatens women’s health, and the prognosis is dismal. Folic acid metabolism affects prognosis, but research on folic metabolism-related genes (FMRs) in BC scarce. We used TCGA-BRCA as training set GSE21653 validation set. Five FMRs (PLAT, SERPINA3, IFNG, SLC19A1, NFKB2) were screened via univariate LASSO Cox regression analyses, a prognostic model was built based multivariate analysis. The showed excellent predictive performance. Differentially expressed high-...
Aims To investigate the diagnostic, predictive, and prognostic value of detection circulating tumor cells (CTCs) using a three-marker (CK19, hMAM CEA) RT-PCR assay in patients with early breast cancer. Patients methods Peripheral blood was obtained from 50 early-stage cancer before any systemic adjuvant therapy analyzed for presence CK-19, CEA mRNA-positive CTCs an assay. The specificity primers used evaluated 20 healthy individuals, 24 benign disease, 30 metastatic correlated clinical...
Papillary thyroid cancer (PTC) is the most common malignancy of endocrine system, with an increase in incidence frequency. Major vault protein (
The vascular endothelial growth factor (VEGF) receptor 2 (VEGFR-2), also called fetal liver kinase 1 (FLK1) in mice and insert domain (KDR) humans, is an cell specific tyrosine that mediates lung cancer angiogenesis. We hypothesized active immunotherapy approach targeting FLK1 may inhibit metastasis. To test this hypothesis, we evaluated whether immune responses to could be elicited by immunization with orally administered DNA vaccine encoding the extracellular (ECD) of (pcDNA3.1-FLK1ECD)...
Abstract Recently some evidence has demonstrated the significance of PSMB8 in various malignancies. Nevertheless, (proteasome subunit beta 8), more familiar field immunology contributing to process antigen presentation, is indeterminate role as a survival predictor human pan-cancer. Besides, how interacts with immune cell infiltration tumor microenvironment requires further research. We then penetrated into analysis expression profile among 33 types cancer TCGA database. The results show...
Skip metastasis, referred to as lymph node metastases the lateral neck compartment without involvement of central compartment, is generally unpredictable in papillary thyroid carcinoma (PTC). This study aims establish an effective predictive model for skip metastasis PTC.Retrospective analysis was performed clinical samples from 18192 patients diagnosed with cancer between 2016 2020. The First Affiliated Hospital Wenzhou Medical University. occureed training set (630 PTC patients) and...
Genomic instability (GI) is among the top ten characteristics of malignancy. Long non-coding RNAs (lncRNAs) are promising cancer biomarkers that reportedly involved in GI. So far, clinical value GI-related lncRNAs (GIlncs) papillary thyroid (PTC) has not been clarified.Integrative analysis lncRNA expression and somatic mutation profiles was performed to identify GIlncs. Analysis differentially expressed group with high- low- cumulative number mutations revealed significant GIlncs PTC....
tRFs and tiRNAs (tRNA-derived fragments) are an emerging class of small noncoding RNAs produced by the precise shearing tRNAs in response to specific stimuli. They have been reported regulate pathological processes numerous human cancers. However, biofunction development progression papillary thyroid cancer (PTC) has not yet. In this study, we aimed explore biological roles PTC discovered that a novel 5'tRNA-derived fragment called tRF-1:30-Gly-CCC-3 (tRF-30) was markedly down-regulated...
Background:: Postmenopausal osteoporosis (PMOP) is a classic type of that has gradually become significant health problem worldwide. There an urgent need for safe alternative therapeutic agent considering the poor strategies currently available this disease. The roots and bark Morus australis tree (Moraceae) are used to make traditional Chinese medicine known as "Morusin", accumulating evidence demonstrated its multiple activities, such anti-inflammatory anti-tumor effects. Objective:: In...
With the rise of big data, people begin to focus on storage it. In this paper, first, we design four different solutions Hadoop platform with HBase, MySQL, XML and plain text for specific data storage. Data is stored in Distributed File System except MySQL solution, which directly Linux System. Second, each write program meet needs. Then run respectively, record execution time monitor system performance - CPU usage, memory usage load during whole execution. Through analyzing comparing...
L Antigen Family Member 3 (LAGE3) is an important RNA modification-related protein. Whereas few studies have interrogated the LAGE3 protein, there limited data on its role in tumors. Here, we analyzed and profiled protein skin cutaneous melanoma (CM) using TCGA, GTEx, or GEO databases. Our showed upregulation of cell lines compared to normal lines. Besides, Kaplan–Meier curves Cox proportional hazard model revealed that was independent survival indicator for CM, especially metastatic CM....
To investigate vaccination with apoptosis colorectal cancer (CRC) cell pulsed autologous dendritic cells (DCs) in advanced CRC, 14 patients were enrolled and treated DCs vaccine to assess toxicity, tolerability, immune clinical responses the vaccine. No severe toxicity was observed well tolerated. The levels of interleukin-2 (IL-2), interleukin-12 (IL-12) interferon-γ (IFN-γ) significantly increased after (P < 0.05). Mean carcinoembryonic antigen (CEA) lever decreased from 99.5 71.4 ng/ml....
Objective To explore the correlation of posttraumatic growth with social support in patients gastrointestinal neoplasms at end life. Methods Cluster random sampling was used to select 280 who were predicted survive no longer than 6 months 10 first- class hospitals Beijing and Tangshan, they investigated by Posttraumatic Growth Inventor (PTGI) Social Support Rate Scale (SSRS). Results The total score PTGI(61.13±16.78)and scores appreciation life(23.71±7.34), personal...
e18000 Background: Chemotherapy plays an important role in the treatment of advanced non-small cell lung cancer (NSCLC), but overall survival (OS) and median time (MST) are not satisfactory. Chinese herbs (CH) is a popular for NSCLC china. Our purpose was to observe efficacy CH by stages combined with chemotherapy versus alone (stage III/IV). Methods: A prospective, randomized, controlled, multicenter, clinical trial conducted on 115 patients assigned group (60) control (55). The treated...
Abstract Recently some evidences have demonstrated the significance of PSMB8 in various malignancies. Nevertheless, (proteasome subunit beta 8), more familiar field immunology contributing to process antigen presentation, is indeterminate role as a survival predictor human pan-cancer. Besides, how interacts with immune cell infiltration tumor microenvironment requires further research. We then penetrated into analysis expression profile among 33 types cancer TCGA database. The results show...