A5101578493- Dialysis and Renal Disease Management
- Structural Behavior of Reinforced Concrete
- Acute Kidney Injury Research
- Parathyroid Disorders and Treatments
- Immune Cell Function and Interaction
- Heart Failure Treatment and Management
- Structural Engineering and Vibration Analysis
- Structural Load-Bearing Analysis
- Advanced Proteomics Techniques and Applications
- Renal Diseases and Glomerulopathies
- Potassium and Related Disorders
- Innovative concrete reinforcement materials
- Software System Performance and Reliability
- Civil and Geotechnical Engineering Research
- Anomaly Detection Techniques and Applications
- Cardiac Arrest and Resuscitation
- Advanced Sensor and Energy Harvesting Materials
- Dental materials and restorations
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Nonlinear Partial Differential Equations
- Heme Oxygenase-1 and Carbon Monoxide
- Transportation Safety and Impact Analysis
- Cancer Immunotherapy and Biomarkers
- Concrete Corrosion and Durability
Southern Medical University
2012-2025
Nanfang Hospital
2015-2025
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2021-2025
Key Laboratory of Guangdong Province
2022-2025
Guangdong Provincial People's Hospital
2023-2025
Ministry of Industry and Information Technology
2022-2024
Changzhou Academy of Intelli-Ag Equipment (China)
2024
National Clinical Research Center for Digestive Diseases
2023-2024
Westlake University
2023
Tsinghua University
2022-2023
Importance The role of mycophenolate mofetil (MMF) in management immunoglobulin A nephropathy (IgAN) remains highly controversial. Objective To evaluate the efficacy and safety MMF patients with IgAN at high risk kidney function loss. Design, Setting, Participants This randomized clinical trial open-label, blinded end-point design was conducted among adults IgAN, proteinuria greater than 1.0 g/d, estimated glomerular filtration rate (eGFR) 30 less 60 mL/min/1.73m 2 or persistent hypertension...
Three-dimensional (3D) curvy electronics has wide-ranging application in biomedical health care, soft machine, and high-density curved imager. Limited by material properties, complex procedures, coverage ability of existing fabrication techniques, the development high-performance 3D remains challenging. Here, we propose an automated wrap-like transfer printing prototype for fabricating electronics. Assisted a gentle uniform pressure field, prefabricated planar circuits on petal-like stamp...
Data-independent acquisition (DIA) mass spectrometry-based proteomics generates reproducible proteome data. The complex processing of the DIA data has led to development multiple analysis tools. In this study, we assessed performance five tools (OpenSWATH, EncyclopeDIA, Skyline, DIA-NN, and Spectronaut) using six datasets obtained from TripleTOF, Orbitrap, TimsTOF Pro instruments. By comparing identification quantification metrics examining shared unique cross-tool identifications, evaluated...
Acute kidney injury (AKI) is in high prevalence worldwide but with no therapeutic strategies. Programmed cell death tubular epithelial cells has been reported to accelerate a variety of AKI, the major pathways and underlying mechanisms are not defined. Herein, we identified that pyroptosis was responsible for AKI progression related ATP depletion renal cells. We found FAM3A, mitochondrial protein assists synthesis, decreased negatively correlated both mice patients AKI. Knockout FAM3A...
The increasing magnitude and density of livestock production on a global scale, the progressive degradation biodiversity, phenomenon climate change have led to unparalleled diversification intricacy in animal diseases. Precisely predicting epidemic trends, achieving early detection outbreaks, accurately identifying pathogens are imperative for developing precise control strategies mitigating risk dissemination. Metagenomic next-generation sequencing (mNGS) has recently transitioned from an...
A comprehensive spatial distribution of the proteome in human body and cancers is fundamental for understanding biology diseases including cancers. Here, we present an anatomically resolved derived from 1781 benign malignant samples 58 major tissue types encompassing 251 specific tissues 25 carcinomas. Based on a spectral library covering over 75% protein-coding genes with 208 understudied 82 missing proteins characterized, quantified 13,000 these using data-independent acquisition...
Background Nephrotic syndrome (NS) is a condition often necessitating continuous kidney replacement therapy (CKRT) due to severe edema and other complications. Anticoagulation critical in CKRT prevent filter clotting, with regional citrate anticoagulation (RCA) being the first-line method. However, hypercoagulable state of NS may require alternative strategies. Optimal patients undergoing lacking. Methods This retrospective observational study included 251 sessions from 122 treated at...
Background Hypokalemia (LK) was associated with peritonitis in peritoneal dialysis (PD) patients, while the role of its degree and duration have not been fully established. Here, we conducted a retrospective cohort study to identify relationships LK PD patients. Methods A total 602 patients our department from Jan 1st, 2009 Dec 31st, 2019 entered last analysis. Data were collected their medical records. Serum potassium (SK) levels, hypokalemia, hypokalemia analysed peritonitis. The time...
Abstract Podocyte injury is a hallmark of glomerular diseases; however, the underlying mechanisms remain unclear. B7-1 increased in injured podocytes, but its intrinsic role controversial. The clinical data here revealed intimate correlation urinary with severity injury. Through transcriptomic and biological assays transgenic adriamycin nephropathy models, we identified key mediator podocyte glomerulosclerosis through series signal transmission to β-catenin. Using LC-MS/MS, Hsp90ab1,...
Abstract Apparent treatment‐resistant hypertension (aTRH) is the most commonly used term to report resistant (RH) and considered as a common problem in dialysis population. However, few reports have focused on peritoneal (PD) hypertensive patients. The authors conducted multi‐center cross‐sectional study involving 1789 PD patients from nine centers Guangdong, China. prevalence of aTRH was estimated by home blood pressure (BP) monitoring. Evaluating drug adherence through Eight‐item Morisky...
Abstract BACKGROUND Few reports have focused on the association between apparent treatment-resistant hypertension (aTRH) and cardiovascular (CV) mortality in peritoneal dialysis (PD) population, thus we conducted this retrospective cohort to explore it. METHODS This was a study from January 2011 2020 with PD patients 4 Chinese centers. aTRH defined according American College of Cardiology Heart Association guidelines. duration calculated as total number months when met diagnostic criteria...
To test the hypothesis whether serum advanced oxidation protein products (AOPP) are associated with increased acute kidney injury (AKI) after cardiopulmonary bypass (CPB) and could serve as a biomarker in this aspect, we performed prospective cohort study. Thirty-five (22.3%) patients developed AKI, 32 age- gender-matched without AKI were selected control. Serum AOPP 1 h CPB significantly higher among compared non-AKI (81.8 ± 18.6 versus 67.4 12.5 μmol/L, p < 0.001), an area under...
Abstract Background: Currently, no satisfactory biomarkers are available to screen for esophageal squamous cell carcinoma (ESCC). The goal of this study was find and establish a serum protein fingerprint model early diagnosis ESCC using the ClinProt protocol matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Methods: Serum samples were collected from 62 patients with ESCC, nine adenocarcinoma (EA) 38 healthy individuals. Proteomic spectra charge...
Human alpha 1-antitrypsin (A1AT) is involved in the pathophysiological process underlying ischemic acute kidney injury (AKI). To test hypothesis that serum A1AT (sA1AT) a predictor for severe AKI after cardiopulmonary bypass (CPB), we conducted prospective cohort study 201 patients undergoing cardiac surgery.We collected blood and urine samples, analyzed sA1AT other biomarkers during perioperative period. Severe defined as Kidney Disease Improving Global Outcomes (KDIGO) stage 2 or 3,...