A5101434248- Bone health and treatments
- Wnt/β-catenin signaling in development and cancer
- Medical Imaging and Pathology Studies
- Bone fractures and treatments
- Epigenetics and DNA Methylation
- Cancer Diagnosis and Treatment
- Renal and related cancers
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Pelvic and Acetabular Injuries
- Cancer-related Molecular Pathways
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Cannabis and Cannabinoid Research
- Hip and Femur Fractures
- Immunotherapy and Immune Responses
- Ovarian function and disorders
- Computational Drug Discovery Methods
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- MRI in cancer diagnosis
- Biomarkers in Disease Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Medical Malpractice and Liability Issues
- Breast Lesions and Carcinomas
Nanfang Hospital
2019-2024
Southern Medical University
2019-2024
Peking University
2023
Peking University Third Hospital
2023
Sun Yat-sen University
2023
Fifth Affiliated Hospital of Sun Yat-sen University
2023
Key Laboratory of Guangdong Province
2022
National Clinical Research
2022
Shanghai First People's Hospital
2018-2021
Shanghai Jiao Tong University
2013-2021
Abstract Tubular injury and peripheral fibroblast activation are the hallmarks of chronic kidney disease (CKD), suggesting intimate communication between two types cells. However, underlying mechanisms remain to be determined. Exosomes play a role in shuttling proteins other materials recipient In our study, we found that exosomes were aroused by β‐catenin renal tubular Osteopontin (OPN), especially its N‐terminal fragment (N‐OPN), was encapsulated β‐catenin‐controlled cell‐derived exosome...
Chronic kidney disease (CKD) has a high prevalence worldwide and is an intricate issue to whole medical society. Renal fibrosis the common pathological feature for various kinds of CKD. As anti-aging protein, Klotho predominantly expressed in renal tubular epithelial cells. Reports show could retard age-related fibrosis. Mitochondrial dysfunction plays important role cellular senescence. However, mitochondrial CKD not yet been determined. In this study, we treated unilateral...
Renal fibrosis is a common feature in various chronic kidney diseases (CKD). Tubular cell damage main characterization which results from dysregulated fatty acid oxidation (FAO) and lipid accumulation. Cannabinoid Receptor 2 (CB2) contributes to renal fibrosis, however, its role FAO dysregulation tubular cells not clarified. In this study, we found CB2 plays detrimental metabolism cells.
Droop control and inertia are the typical modes for energy storage system (ESS) suppressing power oscillations. However, when effect is enhanced to some certain extent, ESS will limit output device maximum (termed modulation mode) be out of expected because limited converter capacity. This paper focuses on evaluation index oscillation suppression compares ability rate change rotor speed with different modes. The study shows that oscillations can better suppressed than droop by providing fast...
Polycystic ovary syndrome (PCOS) is closely related with the onset and development of metabolic abnormalities. However, correlation between PCOS kidney injury has not been clarified, underlying mechanism remains unknown. Herein, we performed a prospective survey in 55 69 healthy participants. Furthermore, analyses serum testosterone renal functional manifestations patients subjects, including urinary albumin to creatinine ratio (UACR), κ-light chains (KapU), λ-light (LamU), α1-microglobulin...
Abstract Podocyte injury is a hallmark of glomerular diseases; however, the underlying mechanisms remain unclear. B7-1 increased in injured podocytes, but its intrinsic role controversial. The clinical data here revealed intimate correlation urinary with severity injury. Through transcriptomic and biological assays transgenic adriamycin nephropathy models, we identified key mediator podocyte glomerulosclerosis through series signal transmission to β-catenin. Using LC-MS/MS, Hsp90ab1,...
Aging is an important risk factor for kidney injury. Energy homeostasis plays a key role in retarding aging, and mitochondria are responsible energy production. In the kidney, renal tubular cells possess high abundance of to meet consumption. AMPK evolutionarily conserved serine/threonine kinase which central maintaining mitochondrial homeostasis. Besides that, also commands autophagy, clearing recycling process maintain cellular However, effect activators on aging has not been fully...
Limited therapeutic interventions are clinically available for treating aggressive endometrial cancer (EC). Therefore, effective therapies urgently required. the present study investigated role of ∆9-tetrahydrocannabinol (THC), which is reported to impact proliferative and migratory activities during impairment progression. In study, cell migration in response THC was measured using transwell assays. Using western blot analysis, levels cannabinoid receptors EC tissues were detected pathways...
Renal fibrosis is a common feature of various chronic kidney diseases (CKD). However, its underlying mechanism has not been totally clarified. C-X-C motif chemokine receptor (CXCR) family plays role in renal fibrosis, however, detailed mechanisms have elucidated. Here, we report that CXCR2 potential tubular cell senescence and associated with β-catenin-activated mitochondrial dysfunction. one most increased members among CXCR unilateral ureteral obstruction (UUO) mice. was expressed...
The bone is among the most common sites of metastasis in patients with lung cancer. Over 30%40% cancers can develop metastasis, and no effective therapeutic methods exist clinic cases. Wnt/-catenin signaling Dickkopf1 (DKK1) play important roles progression cancer, which preferentially metastasizes to skeleton. However, role DKK1 osteotropism small cell cancer (SCLC) remains be elucidated. This study aimed define SCLC investigate underlying mechanisms. Our results demonstrated that...
By using the C‐terminal 112‐residue of band 3 to screen K562 cDNA library, we find that p16 interacts with 3, which was confirmed both in yeast and mammalian cells. Functional experiments show facilitates movement plasma membrane increased anion transport activity 293t Moreover, expression endogenous cells at 24 36 h after transfection 3. Our findings provide a novel regulation pathway for p16.
To test the hypothesis that activated extracellular signal-regulated kinase (ERK) regulates P65-miR23a/27a/24 axis in gastric cancer (GC) and ERK-P65-miR23a/27a/24 plays an important role development of GC, to evaluate gastrin GC progression axis. The component levels four fresh tissues, 101 paraffin-embedded tissues cell lines were determined by Western blotting, immunohistochemistry (IHC) or qRT-PCR. effects on first evaluated measuring serum 30 healthy 70 patients performing a correlation...
Among all malignancies, lung cancer is the leading cause of cancer-related deaths in China. Bone metastasis one most common complications and important factors affecting prognosis patients, which resulting very poor therapeutic effects. Previously, we have demonstrated that expression levels Dickkopf1 (DKK1), a protein involved cell regulation proliferation, was dramatically higher cells tendency to metastasize invade bone tissue (SBC-5 cells) compared with do not (SBC-3 cells)....
Background and objectives Vertical femoral neck fractures (VFNFs) in young patients lead to significant biomechanical instability. Multitudinous internal fixation devices have been developed utilized clinical interventions. However, there has yet be a consensus expert opinion regarding the optimal configurations. This study aims conduct network meta-analysis evaluate safety efficacy of all currently recognized procedures for treatment VFNFs individuals. Methods Comprehensive literature...