A5101674115- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Lung Cancer Research Studies
- Drug Transport and Resistance Mechanisms
- Caveolin-1 and cellular processes
- Catalytic Processes in Materials Science
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Prenatal Screening and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Ion Transport and Channel Regulation
- Glycosylation and Glycoproteins Research
- Algal biology and biofuel production
- Histone Deacetylase Inhibitors Research
- Solar Thermal and Photovoltaic Systems
- Membrane Separation Technologies
- Sirtuins and Resveratrol in Medicine
- Neuroblastoma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- AI in cancer detection
- Plant Diversity and Evolution
- MicroRNA in disease regulation
Shanghai Jiao Tong University
2009-2023
Shanghai First People's Hospital
2016-2023
The First Affiliated Hospital, Sun Yat-sen University
2021
Sun Yat-sen University
2021
Beihang University
2015
Shandong Agricultural University
2013
Dalian Ocean University
2009
BACKGROUND AND PURPOSE Anion exchanger 1 (AE1) is an integral membrane protein found in erythrocytes. Our previous studies have demonstrated that AE1 expressed human gastric cancer cells and may be involved the carcinogenesis of cancer. In this study, we further investigated role anti‐tumour effects AE1‐targeted small interfering RNAs (siRNAs) two experimental models EXPERIMENTAL APPROACH Molecular cellular experiments were performed to elucidate malignant transformation epithelium siRNAs on...
Lymph node metastasis is one of the most important prognostic factors gastric cancer. However, effect germinal centers in lymph nodes on prognosis patients with cancer has not been reported. This study aimed to investigate contribution center generation parameters and clinicopathological significance cancer.We retrospectively reviewed who underwent surgery from October 2012 June 2022. We analyzed 5484 (210 patients) calculated rate (LNMR) proportion non-metastatic containing three or more...
Human anion exchanger 1 and 2 (AE1 AE2) mediate the exchange of Cl−/HCO3 − across plasma membrane regulate intracellular pH (pHi). AE1 is specifically expressed on surface erythrocytes, while AE2 widely in most tissues, particularly abundant parietal cells. Previous studies showed that an interaction between p16 a key event gastric cancer (GC) progression, but importance GC unclear. The relationship among AE1, cells was characterized by molecular cellular experiments. expression pHi were...
Our previous studies demonstrated that expression and interaction of p16 with anion exchanger 1 (AE1) in gastric cancer cells is correlated progression shorter survival the cancer. In this article, effects gastrin on AE1 its implication prevention treatment were studied by molecular biology techniques, animal experiment clinical analysis. The results showed human body carcinoma was downregulated along cancer, suggesting reverse correlations between vivo. Further experiments indicated...
Idiopathic acquired pure red cell aplasia (PRCA) is a rare, autoimmune-related disease. This study aimed to describe the previously unidentified DNA alterations associated with PRCA. Here, next generation sequencing using panel containing 295 critical genes was applied detect potentially pathogenic mutations in four patients A total of 529 were identified and further classified into three categories, namely, uncertain (n = 25), likely benign 20) 484) mutations, based on American College...
Heat stress, clinically known as hyperthermia, is a promising adjunctive modality in cancer treatment. However, the efficacy of hyperthermia monotherapy limited and underlying mechanism remains poorly understood. Targeting histone modifications an emerging strategy for therapy, but little regarding role heat stress altering these modifications. Here, we report that shock inhibits H3K9 acetylation (H3K9ac) via deacetylase 6 (HDAC6) regulation. interaction between HDAC6 protein 90 (HSP90),...
In order to elucidate molecular genetic mechanism of laying hen reproduction at the transcriptional level and structure significantly differential genes, mRNA display reverse northern dot-blot were used detect expression genes in ovary tissue low-yield hens high-yield present study. Sixteen 32-week-old CAU-pink divided into two groups performance was measured. The results showed that only egg numbers different between groups; from 15 primer pairs, a total 336 bands displayed which 59 cDNA...
Abstract:
The large subunit ribulose-1, 5-bisphosphate carboxylase/oxygenase (rbcL) is a gene cluster directly related to photosynthetic carbon fixation and because of its important biological functions, the structure evolution history rbcL great interest world's scientists. To elucidate evolutionary rbcL, genes from 7 kinds algae Laminariaceae 6 Alaruaceae were selected. Then phylogenetic relationships explored by neighbour-joining minimum-evolution methods. Based on two analysis, we knew that...
Gastric cancer is one of the most common cancers, which ranks third among leading causes death. Biopsy gastric mucosa a standard procedure in screening test. However, manual pathological inspection labor-intensive and time-consuming. Besides, it challenging for an automated algorithm to locate small lesion regions gigapixel whole-slide image make decision correctly.To tackle these issues, we collected large-scale dataset with detailed region annotation designed analyzing framework consisting...
Abstract Study question Whether mRNA transcriptome of biopsied trophectoderm (TE) in human pre-implantation blastocyst can predict embryo karyotype? Summary answer TE precisely whole-chromosome aneuploidies but not mosaicism or segmental aneuploidies. What is known already Karyotype well recognized by PGT-A. However, genome can’t demonstrate gene expression level which might infer the development potential euploidy. Transcriptome singe-cell RNA-seq has revealed lineage segregation...
Abstract Study question Whether mRNA transcriptome of biopsied trophectoderm (TE) in human pre-implantation blastocyst can predict embryo karyotype? Summary answer TE precisely whole-chromosome aneuploidies but not mosaicism or segmental aneuploidies. What is known already Karyotype well recognized by PGT-A. However, genome can’t demonstrate gene expression level which might infer the development potential euploidy. Transcriptome singe-cell RNA-seq has revealed lineage segregation...