A5000724192- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Advanced Nanomaterials in Catalysis
- Porphyrin and Phthalocyanine Chemistry
- Lung Cancer Research Studies
- Luminescence and Fluorescent Materials
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Photoacoustic and Ultrasonic Imaging
- Lung Cancer Diagnosis and Treatment
- Hydrogels: synthesis, properties, applications
- Cholinesterase and Neurodegenerative Diseases
- Cancer Cells and Metastasis
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Molecular Sensors and Ion Detection
- Immune Cell Function and Interaction
- Effects of Radiation Exposure
- Sirtuins and Resveratrol in Medicine
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- Luminescence Properties of Advanced Materials
Henan Cancer Hospital
2004-2025
Jiangxi University of Science and Technology
2025
Shandong University
2011-2024
Zhengzhou University
2014-2024
Ningbo University
2024
Soochow University
2022-2024
Shanghai Institute of Materia Medica
2022-2024
Chinese Academy of Sciences
2022-2024
Northeastern University
2022-2024
National Center for Nanoscience and Technology
2022-2023
A photosensitizer-based nanoplatform demonstrated amplified photodynamic immunotherapy by tumor microenvironment modulation.
A self-amplifying nanodrug was precisely designed to reprogram the Janus-faced nature of ferroptosis via harnessing positive role along with reversing its inherent negative achieve optimal ferroptotic tumor therapy.
Afterglow imaging holds great potential for ultrasensitive biomedical imaging. As it detects photons after the cessation of real-time light excitation, autofluorescence can therefore be effectively eliminated. However, afterglow is still in its infant stage due to lack agents with satisfactory lifetime, biocompatibility, and high luminescence brightness, particularly near-infrared region vivo applications. To address these issues, this study first time reports chlorin nanoparticles (Ch-NPs)...
Photodynamic therapy (PDT), which utilizes type I photoreactions, has great potential as an effective cancer treatment because of its hypoxia-tolerant superiority over the commonly used II pathway. A few photosensitizers are exploited; however, they majorly induce cytotoxicity and possess poor tumor specificity low-efficient theranostics. To resolve this issue, herein aminopeptidase N (APN)-activated phototheranostic probe (CyA) is reported for anti-hypoxic PDT in conjunction with...
The antitumor immune response involves a cascade of three phases, namely, antigen presentation (Phase I), lymphocyte activation and proliferation/differentiation II), tumor elimination III). Therefore, an ideal immunotherapy nanoplatform is one that can simultaneously execute these phases. However, it great challenge to develop single which deliver individual immunoagent their on-demand target sites for tailoring phases because the different restricted by Herein, first time we reported...
Fluorescence imaging in the second near-infrared (NIR-II) window holds great promise for vivo visualization of amyloid-β (Aβ) pathology, which can facilitate characterization and deep understanding Alzheimer's disease (AD); however, it has been rarely exploited. Herein, we report development NIR-II fluorescent reporters with a donor-π-acceptor (D-π-A) architecture specific detection Aβ plaques AD-model mice. Among all designed probes, DMP2 exhibits highest affinity to fibrils specifically...
Imaging to evaluate tumor-associated neutrophils (TANs) is imperative for cancer immunotherapy but remains challenging. We herein report an activatable semiconducting polymer nanoprobe (SPCy) near-infrared fluorescence (NIRF) and photoacoustic (PA) imaging of neutrophil elastase (NE), a biomarker TANs. SPCy comprises conjugated with hemicyanine (hemi-Cy) dye caged by NE-cleavable peptide as the side chain. After systemic administration, passively targets tumor reacts NE "uncage" hemi-Cy,...
Cancer-associated fibroblasts (CAFs) are the major components of tumor-associated matrix and play an important role in tumor progression immunosuppression. Therefore, precise theranostics CAFs beneficial for CAFs-targeted therapies. However, imaging agents enabling have been rarely exploited. To tackle this issue, a molecular pro-theranostic probe (FMP) with activatable fluorescence, photoacoustic (PA) imaging, photodynamic therapy (PDT) is developed response to fibroblast activation protein...
Abstract Activatable afterglow luminescence nanoprobes enabling switched “off-on” signals in response to biomarkers have recently emerged achieve reduced unspecific and improved imaging fidelity. However, such always use a biomarker-interrupted energy transfer obtain an activatable signal, which necessitates strict distance requisition between donor acceptor moiety (<10 nm) hence induces low efficiency non-feasibility. Herein, we report organic upconversion cocktail nanoparticles (ALCNs)...
Abstract Reperfusion injury of ischemic stroke, characterized by the uncontrolled production reactive oxygen species (ROS) and inflammatory reactions, continues to present a major problem in clinical treatment. Neutrophils are forerunners infiltrate cerebral regions contribute reperfusion injury. Herein, this study reports tailored “burning bridges” strategy designing biomimetic nanozymes (D@HPB@SPM NPs) diminish stroke. D@HPB@SPM NPs composed sialic acid (SA)‐modified platelet membrane...
Development of new photosensitizers (PSs) with high photodynamic efficacy and minimal side effects is great interest in therapy (PDT). In this work, we reported several pyridine-embedded phenothiazinium (pyridophenothiazinium) dyes, which could be conveniently synthesized a few short steps acted as highly efficient potent PSs to selectively localize lysosomes photosensitively kill cancer cells. Among them, compound 5, possessed the ability promoting intracellular reactive oxygen species...
Abstract Massage RNA (mRNA) vaccines represent a new strategy for advanced cancer immunotherapy. To protect mRNA from degradation and deliver to targeted cells, lipid nanoparticles (LNPs) are extensively utilized as non‐viral vectors. However, the stability of mRNA‐laden LNPs substantially hinders their clinical application. Development thermostable durable nanovaccines is urgently needed. Here, hyaluronan dynamic hydrogel reported resiquimod (R848)‐laden (HA‐mRLNPs) at room temperature A...
Abstract Despite remarkable achievements in cancer immunotherapy, significant challenges persist pancreatic ductal adenocarcinoma (PDAC) treatment. Particularly, there is a critical issue of inadequate intratumoral infiltration effector T cells, primarily attributed to the physical “hard” barrier caused by extracellular matrix (ECM) and “soft” imposed immune suppression. Here, dual‐warhead nanomedicine reported that effectively targets attacks barriers precisely sensitize PDAC immunotherapy....
Photodynamic therapy (PDT) is a minimally invasive treatment for many diseases, including infections and tumors. Nevertheless, clinical utilization of PDT severely restricted due to the shortcomings photosensitizers, especially their low water solubility poor tumor selectivity. iRGD (internalizing RGD, CRGDKGPDC), nine-unit cyclic peptide, was applied as an active ligand realize homing tissue penetration. Herein, we innovatively fabricated novel OFF-ON mode iRGD-based peptide amphiphile (PA)...
Potentiating systemic immunity against breast cancer is in the most urgent demand as less sensitive to immune checkpoint blockade. Although phototherapy and some chemotherapy can trigger immunogenic cell death (ICD) for T cell-mediated antitumor response, their immunotherapy efficacy severely restricted by insufficient phototherapeutic capability severe multidrug resistance (MDR). Inspired both hypersensitivity key role of MDR mitochondria, a rationally engineered amplifier via...