During the past decade, increasing attention has been paid to photoluminescent nanocarbon materials, namely, carbon quantum dots (CQDs). It is gradually accepted that surface engineering plays a key role in regulating properties and hence applications of CQDs. In this paper, we prepared highly charged CQDs through one-pot pyrolysis with citric acid as source room-temperature imidazolium-based ionic liquid capping agent. The as-prepared exhibit high yields up 25.1% are stable under various...

The antitumor immune response involves a cascade of three phases, namely, antigen presentation (Phase I), lymphocyte activation and proliferation/differentiation II), tumor elimination III). Therefore, an ideal immunotherapy nanoplatform is one that can simultaneously execute these phases. However, it great challenge to develop single which deliver individual immunoagent their on-demand target sites for tailoring phases because the different restricted by Herein, first time we reported...

Here, we prepared novel redox-sensitive drug delivery system based on copolymer-drug conjugates methoxy poly(ethylene glycol)-poly(γ-benzyl l-glutamate)-disulfide-docetaxel (mPEG-PBLG-SS-DTX) to realize the desirable cancer therapy. First, copolymers of l-glutamate) (mPEG-PBLGs) with different molecular weight (mPEG2000-PBLG1750 and mPEG5000-PBLG1750) were synthesized via ring open polymerization (ROP) 5-benzyl-l-glutamate-N-carboxyanhydride (γ-Bzl-l-Glu-NCA) initiated by...

Abstract Phototherapy as a promising cancer diagnostic and therapeutic strategy has aroused extensive attention. However, single‐wavelength near‐infrared (NIR) light–triggered combinational treatment of photothermal therapy (PTT) photodynamic (PDT) is still great challenge. Herein, multifunctional micelle activated by laser for simultaneous PTT PDT well fluorescence imaging developed. Briefly, new indocyanine green (IR820) conjugated to d ‐α‐tocopheryl polyethylene glycol 1000 succinate...

Injectable and sprayable hydrogels have attracted considerable attention for application in the biomedical field owing to their high moldability efficiency encapsulating therapeutics cells. Herein, we report spontaneous assembly of injectable via a one-step mixing solutions tannic acid (TA) O-carboxymethyl chitosan (CMCS) without an external stimulus. The presence 1,4-benzenediboronic (BDBA) improves mechanical properties reduces gelation time resulting hydrogels. assemble hydrogen bonds...

The concept of integrating immunogenic cell death (ICD) with tailoring the immunosuppressive tumor microenvironment (TME) is promising for immunotherapy. Photothermal therapy (PTT) could efficiently induce ICD, while an indoleamine 2,3-dioxygenase (IDO) inhibitor convert "cold" TME. Therefore, combination PTT and IDO attractive approach Unfortunately, rarely reported. Herein, organic photothermal agent IR820 1-methyl-tryptophan (1MT) were, first time, designed to be all-rolled-into-one...

Abstract Background Premature ovarian insufficiency (POI) is one of the major causes infertility. We previously demonstrated that transplantation menstrual blood-derived stromal cells (MenSCs) effectively improved function in a murine model POI. Recent studies indicated mesenchymal stem cell-derived exosomes were important components tissue repair. In this study, we investigated therapeutic effects MenSCs-derived (MenSCs-Exos) rat POI and its mechanism restoring ovulation. Methods Ovaries...

Abstract Control of self-assembly is significant to the preparation supramolecular materials and illustration diversities in either natural or artificial systems. Supra-amphiphiles have remarkable advantages construction nanostructures but control shape size still a great challenge. Here, we fabricate series supra-amphiphiles by utilizing recognition motifs based on heteroditopic porphyrin amphiphile its zinc complex. These amphiphiles can bind with few guests including Cl – , coronene, C 60...

Pickering emulsions stabilized by functional nanoparticles (NPs) have received considerable attention for improving the physical stability and biological function of NPs. Herein, hydrophobic polyphenols were chosen as phenolic ligands to form metal-phenolic network (MPN) coatings on NPs (e.g., silica, polystyrene) mediated sono-Fenton reaction. The MPN modulated surface wettability charges achieved emulsification behavior preparing with pH responsiveness oxidation resistance. A series...

Supramolecular hydrogels were prepared in the mixtures of a chiral amphiphilic lithocholic acid (LCA) and nonionic surfactant, dodecyldimethylamine oxide (C(12)DMAO), water. With addition LCA to C(12)DMAO micellar solutions, transition from micelles gels occurs at room temperature. Hydrogels can form very low concentrations (below 0.1 wt %), exhibiting super gelation capability. The rheological measurements show strong mechanical strength with an elastic modulus exceeding 5000 Pa yield...

Gelation behavior of lithocholate (LC–) mixed with different monovalent cations in water was detected. The hydrogels consisting tubular networks were formed by introducing alkali metal ions and NH4+ to aqueous solutions at room temperature. formation structures considered be mainly driven the electrostatic interaction assistance a delicate balance multiple noncovalent interactions. It is interesting that increase temperature can induce significant enhancement strength hydrogels, accompanied...

Abstract In order to promote the application range, double‐network hydrogels are usually fabricated improve mechanical properties. this work, chitosan (CS) single‐network were prepared firstly and sodium alginate (SA) was introduced as second network. According scanning electron microscopy (SEM), microstructures of CS SA identified three‐dimensional network pore fiber structure, respectively. The microstructure maintained structure after formation CS/SA due small amount SA. size pores...

Fatty acids, as a typical example of stearic acid, are kind cheap surfactant and have important applications. The challenging problem industrial applications is their solubility. Herein, three organic amines-ethanolamine (EA), diethanolamine (DEA), triethanolamine (TEA)-were used counterions to increase the solubility phase behaviors were investigated systematically. diagrams delineated at 25 50 °C, respectively. phase-transition temperature was measured by differential scanning calorimetry...

We report a facile inking strategy for visual information storage (e.g., writing, printing, and beyond) via surface modification of substrates with polyphenols subsequent in situ formation metal-phenolic networks (MPNs) on the substrates. The reported technique has several advantages compared current printing techniques. Diverse can be used to fulfill requirements different applications painting, stamping). A range colors yellow, blue, green) realized using tannic acid, gallic pyrogallol)...

A novel strategy for preparing single network double cross-linker (SNDCL) hydrogels was proposed and the possessed excellent properties, which can be used human motion monitoring.

Potentiating systemic immunity against breast cancer is in the most urgent demand as less sensitive to immune checkpoint blockade. Although phototherapy and some chemotherapy can trigger immunogenic cell death (ICD) for T cell-mediated antitumor response, their immunotherapy efficacy severely restricted by insufficient phototherapeutic capability severe multidrug resistance (MDR). Inspired both hypersensitivity key role of MDR mitochondria, a rationally engineered amplifier via...

G-quadruplex, assembled from a square array of guanine (G) molecules, is an important structure with crucial biological roles in vivo but also versatile template for ordered functional materials. Although the understanding G-quadruplex structures focus numerous studies, little known regarding control G-quartet stacking modes and spontaneous orientation fibrils. Here, effects different metal ions their concentrations on G-quartets are elucidated. Monovalent cations (typically K + ) facilitate...