A5101408163- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Glioma Diagnosis and Treatment
- Virus-based gene therapy research
- Microtubule and mitosis dynamics
- Cancer Research and Treatments
- Gas Sensing Nanomaterials and Sensors
- Protein Degradation and Inhibitors
- IL-33, ST2, and ILC Pathways
- EEG and Brain-Computer Interfaces
- RNA Interference and Gene Delivery
- ZnO doping and properties
- Galectins and Cancer Biology
- Neuroblastoma Research and Treatments
- Herpesvirus Infections and Treatments
- Traditional Chinese Medicine Studies
- Neural dynamics and brain function
- Signaling Pathways in Disease
- Cellular Mechanics and Interactions
- Analytical Chemistry and Sensors
- Smart Grid and Power Systems
- Antenna Design and Analysis
- Blind Source Separation Techniques
State Grid Corporation of China (China)
2024
China Electric Power Research Institute
2024
Wuhan Institute of Technology
2024
Sichuan University
2024
Yuhuangding Hospital
2024
North China Institute of Science and Technology
2022-2023
Children's Cancer Center
2018-2023
Beijing Jiaotong University
2021-2023
Shanghai Power Equipment Research Institute
2022-2023
Nanjing University of Aeronautics and Astronautics
2023
Abstract Zeolitic imidazolate framework‐8 (ZIF‐8) is an attractive metal organic framework (MOF) in drug delivery. Strong interaction between drugs and ZIF‐8 essential for high loadings through situ construction of MOFs. However, only limited with unique functional groups (COOH, SO 3 H, et al.) can interact be encapsulated satisfactorily so far. Drugs without these are difficult to loaded due the lack strong interaction. Herein a versatile prodrug strategy proposed solve problems...
Quercetin (QT) is one promising candidate for the treatment of various cancers with virtually no toxic side effects. However, its anticancer effect severely restricted by poor bioavailability, low water solubility, and chemical instability in neutral alkaline medium. Herein, zeolitic imidazolate framework-8 (ZIF-8) first reported as multifunctional nanoplatform to codelivery quercetin an agent CuS nanoparticles a photothermal therapy (PTT) synergistic combination chemotherapy PTT well...
Abstract B lymphocytes are activated upon Ag sensing by BCRs. The substrate presenting the can show different degrees of stiffness. It is not clear whether cells respond to changes in In this study we use high-resolution, high-speed live cell imaging techniques capture molecular events activation after recognition Ags tethered polyacrylamide gel substrates with variable stiffness as quantified Young’s modulus (2.6–22.1 kPa). We that initiation extremely sensitive exhibit much stronger...
Interleukin-27 (IL-27) is an immunoregulatory cytokine that suppresses inflammation through multiple mechanisms, including induction of IL-10, but the transcriptional network mediating its diverse functions remains unclear. Combining temporal RNA profiling with computational algorithms, we predict 79 transcription factors induced by IL-27 in T cells. We validate 11 known and discover 5 positive (Cebpb, Fosl2, Tbx21, Hlx, Atf3) 2 negative (Irf9 Irf8) Il10 regulators, generating experimentally...
The three near-infrared-emitting cationic iridium(III) complexes [Ir(pbq-g)2(N∧N)]+PF6– (pbq-g = phenylbenzo[g]quinoline; N∧N bipyridine (1), 1,10-phenanthroline (2), 4,7-diphenyl-1,10-phenanthroline (3)) have been demonstrated as phosphorescent dyes in live cell imaging. These with different ancillary ligands show similar near-infrared (NIR) emission λmax,peak at 698 nm and λmax,shoulder 760 CH2Cl2 solutions, a moderate quantum yield of around 3%. However, these behave quite differently NIR...
Tim-1, a phosphatidylserine receptor expressed on B cells, induces interleukin 10 (IL-10) production by sensing apoptotic cells. Here we show that mice with cell-specific Tim-1 deletion develop tissue inflammation in multiple organs including spontaneous paralysis the central nervous system (CNS). Transcriptomic analysis demonstrates besides IL-10, Tim-1+ cells also differentially express number of co-inhibitory checkpoint receptors TIGIT. Mice TIGIT CNS inflammation, but limited other...
Tim-3 adaptor protein Bat3 regulates T cell terminal differentiation and exhaustion in an mTORC2-dependent manner.
Abstract A rapid and economical method for detecting Salmonella was developed, based on a novel complex immunomagnetic separation, which composed of anti‐ polyclonal antibody (Ab) magnetosome (bacterial magnetic particle, BMP) produced by the bacterium Magnetospirillum gryphiswaldense MSR‐1. BMP‐Ab used to capture from pure suspensions S . dublin , S. enteritidis aesch agona abony bareily mixed Vibrio parahaemolyticus artificially contaminated food samples. Captured were then detected plate...
Purpose: Pediatric glioblastoma multiforme (pGBM) is a highly aggressive tumor in need of novel therapies. Our objective was to demonstrate the therapeutic efficacy MLN8237 (alisertib), an orally available selective inhibitor Aurora A kinase (AURKA), and evaluate which vitro model system (monolayer or neurosphere) can predict vivoExperimental Design: AURKA mRNA expressions were screened with qRT-PCR. In antitumor effects examined three matching pairs monolayer neurosphere lines established...
Feature extraction of EEG signals plays an important role for classifying spontaneous mental activities in EEG-based brain computer interface (BCI). For the non-stationary nature data makes necessary some kind adaptation BCI system, improved feature method based on multivariate adaptive autoregressive (MVAAR) models is proposed and applied to classification Motor imagery. In this paper, three subjects participated experiment which contains tasks including imagination left hand, right hand...