A5031690451- Spectroscopy Techniques in Biomedical and Chemical Research
- Paleontology and Stratigraphy of Fossils
- Spectroscopy and Chemometric Analyses
- Advanced Measurement and Metrology Techniques
- Neuroblastoma Research and Treatments
- Industrial Vision Systems and Defect Detection
- Geology and Paleoclimatology Research
- Microtubule and mitosis dynamics
- Manufacturing Process and Optimization
- Geological and Geophysical Studies
- Video Surveillance and Tracking Methods
- Anomaly Detection Techniques and Applications
- Advanced Image and Video Retrieval Techniques
- Geochemistry and Geologic Mapping
- Genomics and Phylogenetic Studies
- Optical measurement and interference techniques
- Image Retrieval and Classification Techniques
- Evolution and Paleontology Studies
- Optical Imaging and Spectroscopy Techniques
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Environmental Changes in China
- Environmental and Agricultural Sciences
- Sparse and Compressive Sensing Techniques
- Water Quality Monitoring and Analysis
Huaiyin Institute of Technology
2017-2025
Nanjing University of Information Science and Technology
2025
First People's Hospital of Foshan
2025
Xinxiang Medical University
2024
Shanghai Jiao Tong University
2014-2024
Guizhou University
2017-2024
Huazhong Agricultural University
2024
Xuzhou Medical College
2018-2024
Shanghai Mental Health Center
2016-2024
Nanjing Institute of Geology and Paleontology
2013-2024
A finer record of biodiversity We have pressing, human-generated reasons to explore the influence environmental change on biodiversity. Looking into past can not only inform our understanding this relationship but also help us understand current change. Paleontological records depend fossil availability and predictive modeling, however, thus tend give a picture with large temporal jumps, millions years wide. Such scale makes it difficult truly action forces ecological processes. Enabled by...
• MDD has substantial changes in the structure and function of gut microbiota. exhibited decreased amino acids bile increased lipids blood. The blood immune cell subtypes tend to promote inflammation. could be divided into two subtypes, one is correlated with relapse. We revealed integrative discriminative signatures for distinguishing from HC. Major depressive disorder (MDD) involves systemic peripheral microbiota, but current understanding incomplete. Herein, we conducted a multi-omics...
Abstract Novel therapeutic approaches are urgently needed for high-stage neuroblastoma, a major challenge in pediatric oncology. The majority of neuroblastoma tumors p53 wild type with intact downstream signaling pathways. We hypothesize that stabilization would sensitize this aggressive tumor to genotoxic chemotherapy via inhibition MDM2, the primary negative upstream regulator p53. used pharmacologic MDM2-p53 interaction small-molecule inhibitor Nutlin and studied subsequent response cell...
Novel therapies are needed for children with high-risk and relapsed neuroblastoma. We hypothesized that MAPK/ERK kinase (MEK) inhibition the novel MEK1/2 inhibitor binimetinib would be effective in neuroblastoma preclinical models.Levels of total phosphorylated MEK extracellular signal-regulated (ERK) were examined primary tumor samples cell lines by Western blot. A panel established was treated increasing concentrations binimetinib, their viability determined using MTT assays. blot analyses...
Image representation methods based on deep convolutional neural networks (CNNs) have achieved the state-of-the-art performance in various computer vision tasks, such as image retrieval and person re-identification. We recognize that more discriminative feature embeddings can be learned with supervised metric learning handcrafted features for similar applications. In this paper, we propose a new embedding model. To fuse information into CNNs realize embeddings, general fusion unit is proposed...
Abstract The poly(ADP-ribose) polymerase (PARP) inhibitor ABT-888 potentiates the antitumor activity of temozolomide (TMZ). TMZ resistance results from increased O6-methylguanine-DNA methyltransferase (MGMT) and mismatch repair (MMR) system mutations. We evaluated relative importance MGMT activity, MMR deficiency, nonhomologous end joining (NHEJ), PARP in potentiation TMZ. MMR-proficient MMR-deficient leukemia cells with varying as well primary samples, were used to determine IC50 alone...
To develop nanoshells for vascular-targeted photothermal therapy of glioma.The ability conjugated to VEGF and/or poly(ethylene glycol) (PEG) thermally ablate receptor-2-positive endothelial cells upon near-infrared laser irradiation was evaluated in vitro. Subsequent vivo studies mice bearing intracerebral glioma tumors by exposing light after systemically delivering saline, PEG-coated nanoshells, or VEGF-coated nanoshells. The treatment effect monitored with intravital microscopy and...
The Geobiodiversity Database (GBDB – www.geobiodiversity.com), an integrated system for the management and analysis of stratigraphic paleontological information, was started in 2006 became available online 2007. Its goal is to facilitate regional global scientific collaborations focused on correlation, quantitative stratigraphy, systematics, biodiversity dynamics, paleogeography paleoecology. It unique among global, public access databases that it a section-based database system,...
Oxymatrine (OMT), an alkaloid extracted from Sophora japonica (kushen), is used to treat inflammatory diseases and various types of cancer in traditional Chinese medicine. However, the cellular molecular mechanisms underlying anti‑inflammatory activity OMT remain poorly understood. The present study explored protective effect on myocardial injury rats with septic shock by inhibiting activation janus kinase‑signal transducer activator transcription (JAK/STAT) signaling pathway. treatment was...