A5079697562- Pain Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Sleep and Wakefulness Research
- Neuroscience and Music Perception
- Cancer Immunotherapy and Biomarkers
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Music Therapy and Health
- Photoreceptor and optogenetics research
- Neuroendocrine regulation and behavior
- Ion Transport and Channel Regulation
- Immune Cell Function and Interaction
- Nanomaterials for catalytic reactions
- Immunotherapy and Immune Responses
Anhui Medical University
2022-2023
Shanghai Jiao Tong University
2018
Shanghai First People's Hospital
2018
Sound-including music and noise-can relieve pain in humans, but the underlying neural mechanisms remain unknown. We discovered that analgesic effects of sound depended on a low (5-decibel) signal-to-noise ratio (SNR) relative to ambient noise mice. Viral tracing, microendoscopic calcium imaging, multitetrode recordings freely moving mice showed low-SNR sounds inhibited glutamatergic inputs from auditory cortex (ACxGlu) thalamic posterior (PO) ventral (VP) nuclei. Optogenetic or chemogenetic...
Light has been shown to relieve pain, but the underlying neural mechanisms remain unknown. Here, we show that low-intensity (200 lux) green light treatment exerts antinociceptive effects through a circuit from visual cortex projecting anterior cingulate (ACC) in mice. Specifically, viral tracing, vivo two-photon calcium imaging, and fiber photometry recordings activated glutamatergic projections medial part of secondary (V2MGlu) GABAergic neurons ACC, which drives inhibition local...
Remifentanil-induced hyperalgesia (RIH) is a severe but common postoperative clinical problem with elusive underlying neural mechanisms. Here, we discovered that glutamatergic neurons in the thalamic ventral posterolateral nucleus (VPLGlu) exhibited significantly elevated burst firing accompanied by upregulation of Cav3.1 T-type calcium channel expression and function RIH model mice. In addition, identified neuronal thalamocortical circuit VPL projecting to hindlimb primary somatosensory...
Pain is commonly comorbid with anxiety; however, the neural and molecular mechanisms underlying anxiety symptoms in pain (CASP) have not been fully elucidated. In this study, we explored role of acid-sensing ion channel 1a (ASIC1a), located GABAergic neurons from central nucleus amygdala (GABACeA), regulation CASP an acute mouse model. We found that mice displayed significant mechanical sensitization anxiety-like behaviors one day post injection complete Freud's adjuvant (CFA1D)....
Chronic pain caused by disease or injury affects more than 30% of the general population. The molecular and cellular mechanisms underpinning development chronic remain unclear, resulting in scant effective treatments. Here, we combined electrophysiological recording, vivo two-photon (2P) calcium imaging, fiber photometry, Western blotting, chemogenetic methods to define a role for secreted pro-inflammatory factor, Lipocalin-2 (LCN2), mice with spared nerve (SNI). We found that LCN2...