A5029621120- Advanced Drug Delivery Systems
- Pain Mechanisms and Treatments
- Nanoparticle-Based Drug Delivery
- Lanthanide and Transition Metal Complexes
- Spine and Intervertebral Disc Pathology
- Cardiac pacing and defibrillation studies
- RNA Interference and Gene Delivery
- Neurological disorders and treatments
- Pain Management and Opioid Use
- Cardiac Arrhythmias and Treatments
- Peptidase Inhibition and Analysis
- Advanced Polymer Synthesis and Characterization
- Cancer Treatment and Pharmacology
- Nanoplatforms for cancer theranostics
- Advanced MRI Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Wound Healing and Treatments
- Musculoskeletal pain and rehabilitation
- Medical Imaging Techniques and Applications
- Spinal Fractures and Fixation Techniques
- Anesthesia and Pain Management
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Medicinal Plants and Neuroprotection
- Neuroscience and Neuropharmacology Research
The University of Queensland
2015-2025
XinHua Hospital
2019-2025
Shanghai Jiao Tong University
2018-2024
Shanghai First People's Hospital
2018-2024
Jilin University
2023
Institute of Bioengineering and Nanotechnology
2022
Soochow University
2022
First Affiliated Hospital of Soochow University
2022
Weatherford College
2020-2021
Chinese Academy of Tropical Agricultural Sciences
1998-2015
Two important challenges in the field of 19F magnetic resonance imaging (MRI) are maintenance high fluorine content without compromising performance, and effective targeting small particles to diseased tissue. To address these challenges, we have developed a series perfluoropolyether (PFPE)-based hyperbranched (HBPFPE) nanoparticles with attached peptide aptamer as ligands for specific vivo detection breast cancer MRI sensitivity. A detailed comparison HBPFPE (NPs) previously reported...
Diabetic wound healing (DWH) represents a major complication of diabetes where inflammation is key impediment to proper healing. The cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) signaling pathway has emerged as central mediator inflammatory responses cell stress and damage. However, the contribution cGAS-STING activation impaired in DWH remains understudied. In this review, we examine evidence that cGAS-STING-driven critical factor underlying defective DWH. We summarize...
Abstract Oral insulin (INS) is predicted to have the most therapeutic advantages in treating diabetes repress hepatic glucose production through its potential mimic endogenous pathway. Many oral delivery systems been investigated. Layered double hydroxide (LDH) as an inorganic material has widely used drug thanks appealing features such good biocompatibility, low toxicity, and excellent loading capability. However, when delivery, effectiveness of LDH limited due acidic degradation stomach....
19 F magnetic resonance imaging (19 MRI) agents capable of being activated upon interactions with cancer triggers are attracting increasing attention, although challenges still remain for precise and specific detection tissues. In this study, a novel hybrid MRI agent pH-sensitive breast tissues is reported, composite system designed by conjugating perfluoropolyether onto the surface manganese-incorporated layered double hydroxide (Mn-LDH@PFPE) nanoparticles. The NMR/MRI signals from aqueous...
Abstract The conjugation of hydrophilic low‐fouling polymers to therapeutic molecules and particles is an effective approach improving their aqueous stability, solubility, pharmacokinetics. Recent concerns over the immunogenicity poly(ethylene glycol) has highlighted importance identifying alternative low fouling polymers. Now, a new class synthetic water‐soluble homo‐fluoropolymers are reported with sulfoxide side‐chain structure. incorporation fluorine enables direct imaging homopolymer by...
19F magnetic resonance imaging (MRI) is a powerful noninvasive technique that shows tremendous potential for the diagnosis and monitoring of human diseases. Fluorinated compounds are commonly used as MRI contrast agents to develop "hot spot" imaging. To achieve high-resolution MR images, high density nuclei required in agents. However, because inherent hydrophobicity fluorinated moieties, aggregation with fluorine content often observed aqueous solution, resulting attenuated signal low...
Oral administration of vaccines has been limited due to low immune response compared parenteral administration. Antigen degradation in the acidic gastrointestinal environment (GI), mucus barriers, and inefficient cellular uptake by cells are major challenges for oral vaccine delivery. To solve these issues, current study investigates calcium phosphate nanoparticles (CaP NPs) coated with polysaccharides as nanocarriers protein antigen In this design, CaP NP core had an optimized encapsulation...
Imaging agents that can be targeted to specific diseases and respond the microenvironment of diseased tissue are considerable interest due their potential in diagnosing managing diseases. Here we report a new class branched fluorinated glycopolymers as 19F MRI contrast reductive environment, for imaging cancer. The readily prepared by one-pot RAFT polymerization glucose- fluorine-containing monomers presence disulfide-containing cross-linking monomer. incorporation glucose units along...
Biodegradable polymers have been used as carriers in drug delivery systems for more than four decades. Early work crude natural materials particle fabrication, whereas recent has utilized synthetic polymers. Applications include the macroscale, microscale, and nanoscale. Since pioneering 1960’s, an array of products that use biodegradable to encapsulate desired payload approved human by international regulatory agencies. The commercial success these led further research field aimed at...
Catheter-based pulmonary artery denervation (PADN) has achieved promising outcomes to treat hypertension (PH). We herein present stereotactic body radiotherapy (SBRT) as a novel noninvasive approach for PADN. A single fraction of 15 Gy, 20 Gy or 25 was delivered PADN in thromboxane A2 (TxA2) - induced acute PH swine model. demonstrated that by 20-Gy SBRT reduced mean (PA) pressure during the TxA2 challenge. All dosages led deeper area compared with radiofrequency ablation (RFA) and...
Diabetic wounds pose significant clinical challenges due to impaired healing processes, often resulting in chronic, nonhealing ulcers. Asiaticoside (AC), a natural triterpene derivative from Centella asiatica, has demonstrated notable anti-inflammatory and wound-healing properties. However, the synergistic effects of nitric oxide (NO)-a recognized promoter wound healing-combined with AC treating diabetic remain inadequately explored. Ultraperformance liquid chromatography-tandem mass...
Background Human umbilical cord mesenchymal stem cells (UCMSCs) are being investigated in various clinical trials for different conditions, including type 2 diabetes mellitus (T2DM). However, there is limited research on the optimal injection routes UCMSCs T2DM, particularly intravenous injection. Objective The objective of this study aims to investigate efficacy four administration treating T2DM rats, pancreas (DP), tail vein (DT), intraperitoneal (DI), and dorsal pancreatic artery (DPA)....
Abstract It is reported that poly(lactic‐co‐glycolic acid) (PLGA) nanoparticles (NPs) coated with chitosan and its derivatives, such as glycol (GC), can enhance the targeted uptake of PLGA NPs by intestinal epithelial cells. However, optimal amount GC for coating specific mechanisms which it facilitates endocytosis remain unclear. In this study, PLGA‐NPs are prepared using either single‐ or double‐emulsion methods varying amounts GC. The results confirmed GC‐coated internalized via both...
The conjugation of hydrophilic polymers to proteins is an effective approach prolonging their circulation time in the bloodstream and, hence, improving delivery target region interest. In this work, we report synthesis protein-polymer conjugates using a highly water-soluble sulfoxide-containing polymer, poly(2-(methylsulfinyl)ethyl acrylate) (PMSEA), through combination "grafting-to" and "grafting-from" methods. Oligomeric MSEA was synthesized by conventional reversible...
This work provides advice for PLGA-based nanoparticle fabrication and drug encapsulation quantification as well the minimum required information to be reported allowing reproducibility.
Abstract The conjugation of hydrophilic low‐fouling polymers to therapeutic molecules and particles is an effective approach improving their aqueous stability, solubility, pharmacokinetics. Recent concerns over the immunogenicity poly(ethylene glycol) has highlighted importance identifying alternative low fouling polymers. Now, a new class synthetic water‐soluble homo‐fluoropolymers are reported with sulfoxide side‐chain structure. incorporation fluorine enables direct imaging homopolymer by...