A5039527416- Diet and metabolism studies
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced Polymer Synthesis and Characterization
- RNA Interference and Gene Delivery
- Metabolism and Genetic Disorders
- Advanced Drug Delivery Systems
- Mitochondrial Function and Pathology
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Supramolecular Chemistry and Complexes
- Polymer Surface Interaction Studies
- Dietary Effects on Health
- Anesthesia and Neurotoxicity Research
- Epilepsy research and treatment
- Peptidase Inhibition and Analysis
- Lipid Membrane Structure and Behavior
- Pain Management and Opioid Use
- Medical Imaging Techniques and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Anesthesia and Pain Management
- Circadian rhythm and melatonin
- Lanthanide and Transition Metal Complexes
- Amino Acid Enzymes and Metabolism
The University of Queensland
2020-2024
Abstract The conjugation of hydrophilic low‐fouling polymers to therapeutic molecules and particles is an effective approach improving their aqueous stability, solubility, pharmacokinetics. Recent concerns over the immunogenicity poly(ethylene glycol) has highlighted importance identifying alternative low fouling polymers. Now, a new class synthetic water‐soluble homo‐fluoropolymers are reported with sulfoxide side‐chain structure. incorporation fluorine enables direct imaging homopolymer by...
Polymeric fluorinated nanoparticles (PFNPs) are useful materials in many applications, especially the field of 19F magnetic resonance imaging (MRI). Despite development numerous PFNPs with diverse chemical compositions and structures, those high fluorine content capable highly sensitive MRI remain scarce. Here we report an elegantly designed aqueous photo-polymerization-induced self-assembly (photo-PISA) system for synthesis effective applications. This innovative photo-PISA is enabled by...
The conjugation of hydrophilic polymers to proteins is an effective approach prolonging their circulation time in the bloodstream and, hence, improving delivery target region interest. In this work, we report synthesis protein-polymer conjugates using a highly water-soluble sulfoxide-containing polymer, poly(2-(methylsulfinyl)ethyl acrylate) (PMSEA), through combination "grafting-to" and "grafting-from" methods. Oligomeric MSEA was synthesized by conventional reversible...
Abstract The conjugation of hydrophilic low‐fouling polymers to therapeutic molecules and particles is an effective approach improving their aqueous stability, solubility, pharmacokinetics. Recent concerns over the immunogenicity poly(ethylene glycol) has highlighted importance identifying alternative low fouling polymers. Now, a new class synthetic water‐soluble homo‐fluoropolymers are reported with sulfoxide side‐chain structure. incorporation fluorine enables direct imaging homopolymer by...
Intermittent fasting enhances neural bioenergetics, is neuroprotective, and elicits antioxidant effects in various animal models. There are conflicting findings on seizure protection, where intermittent regimens often cause severe weight loss resembling starvation which unsustainable long-term. Therefore, we tested whether a less intensive regimen such as time-restricted feeding (TRF) may confer protection.
Abstract Substantial preclinical data have validated cyclic hexapeptide complement C5a receptor 1 antagonists (C5aRAs) that target immune cells, as novel therapies for a range of inflammatory diseases currently limited effective treatment options. However, like most small‐molecule peptides, their poor oral bioavailability and short circulation half‐life are major hurdles clinical translation. Here, single emulsion technique is employed to produce poly(lactic‐ co ‐glycolic) acid nanoparticles...
Peptides hold promise as therapeutics, they have high bioactivity and specificity, good aqueous solubility, low toxicity. However, typically suffer from short circulation half-lives in the body. To address this issue, here, we developed a method for encapsulation of an innate-immune targeted hexapeptide into nanoparticles using safe non-toxic FDA-approved materials. Peptide-loaded were formulated two-stage microfluidic chip. Microfluidic-related factors (i.e., flow rate, organic solvent,...
Gold nanorods (GNRs) are widely used in various biomedical applications such as disease imaging and therapy due to their unique plasmonic properties. To improve bioavailability, GNRs often need be coated with hydrophilic polymers so impart stealth Poly(ethylene glycol) (PEG) has been long a coating material for GNRs. However, there is increasing acknowledgement that the amphiphilic nature of PEG facilitates its interaction protein molecules, leading immune recognition consequent side...