A5055486123- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Drug Solubulity and Delivery Systems
- Mesoporous Materials and Catalysis
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
- Curcumin's Biomedical Applications
- MicroRNA in disease regulation
- Innovative Microfluidic and Catalytic Techniques Innovation
- Sirtuins and Resveratrol in Medicine
- Cannabis and Cannabinoid Research
- Nanoplatforms for cancer theranostics
- Additive Manufacturing and 3D Printing Technologies
- Advancements in Transdermal Drug Delivery
- Graphene and Nanomaterials Applications
- Antibiotics Pharmacokinetics and Efficacy
- Carbon and Quantum Dots Applications
- Extracellular vesicles in disease
- Biopolymer Synthesis and Applications
- Quantum Dots Synthesis And Properties
- Pancreatic function and diabetes
- Nanoparticles: synthesis and applications
- Glioma Diagnosis and Treatment
- Polymer Surface Interaction Studies
The University of Queensland
2016-2025
Mater Research
2015-2025
University of Vienna
2023-2025
Translational Research Institute
2014-2023
National Health and Medical Research Council
2018
Institute of Bioengineering and Nanotechnology
2013
Herein, we report a core–shell pH-responsive drug-carrier based on chitosan-coated mesoporous silica nanospheres. The efficient positively charged polymer (chitosan) coating is realized by the phosphoramidate covalent bonding between phosphonate groups surface of nanoparticles (MSNs) and amino chitosan. A release ibuprofen has been achieved varying shell structure chitosan in designed pH 4.0–7.4 solution. Under basic conditions, forms gel like which insoluble hence prevents at 7.4. When...
Extracellular vesicles (EVs) occur in a variety of bodily fluids and have gained recent attraction as natural materials due to their bioactive surfaces, internal cargo, role intercellular communication. EVs contain various biomolecules, including surface cytoplasmic proteins; nucleic acids that are often representative the originating cells. can transfer content other cells, process is thought be important for several biological processes, immune responses, oncogenesis, angiogenesis. An...
I want to break free: Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5-aminosalicylic acid (5-ASA) and sulfapyridine, generate enzyme-responsive nanocarriers. In the presence colon-specific enzyme azo-reductase (orange), 5-ASA sulfapyridine efficiently released.
In this proof-of-concept study, an agricultural biocide (imidacloprid) was effectively loaded into the mesoporous silica nanoparticles (MSNs) with different pore sizes, morphologies and structures for termite control. This resulted in a large surface area, tunable diameter small particle size, which are ideal carriers adsorption controlled release of imidacloprid. The effect area structure on uptake imidacloprid systematically studied. It found that amount profile were dependent type...
Resveratrol (RES) is a naturally existing polyphenol which exhibits anti-oxidant, anti-inflammatory, and anti-cancer properties. In recent years, RES has attracted attention for its synergistic effect with other drugs the treatment of drug resistant cancers. However, faces issues poor pharmacokinetics, stability low solubility limits clinical application. present study, been loaded onto uniformly sized (~60 nm) mesoporous silica nanoparticles (MSNs) to improve in vitro anti-proliferative...
Abstract This commentary article conveys the views of board Nanomedicine and Nanoscale Delivery Focus Group Controlled Release Society regarding decision United States National Cancer Institute (NCI) in halting funding for Centers Nanotechnology Excellence (CCNEs), subsequent editorial articles that broadened this discussion.
Mesoporous silica nanoparticles (MCM-41) with different surface chemistry were used as carrier system to study its influence on drug delivery and anticancer activity of curcumin (CUR). CUR was encapsulated in pristine MCM-41 (hydrophilic negatively charged), amino functionalized (MCM-41-NH2 which is hydrophilic positively methyl (MCM-41-CH3 hydrophobic charged) evaluated for vitro release cell cytotoxicity human squamous carcinoma line (SCC25). Various techniques employed evaluate the...
Sizing drugs down to the submicron and nanometer scale using nanoparticles has been extensively used in pharmaceutical industries overcome poor aqueous solubility of potential therapeutic agents. Here, we report encapsulation release resveratrol, a promising anti-inflammatory anticancer nutraceutical, from mesopores MCM-48-type silica nanospheres various particle sizes, i.e., 90, 150, 300 nm. Furthermore, influence carrier pore size on drug was also evaluated (3.5 vs 7 nm). From our results,...
Herein, we demonstrate the role of surface modification nanocarriers on their ability to load and protect sensitive payloads.
The prognosis of brain cancers such as glioblastoma remains poor despite numerous advancements in the field neuro-oncology. presence blood barrier (BBB) along with highly invasive and aggressive nature presents a difficult challenge for developing effective therapies. Temozolomide (TMZ) is first line agent used clinic it has been useful increasing patient survival rates. However, TMZ suffers from issues related to its pharmacokinetics, short plasma half-life (2 h), subjected P-gp efflux,...