A5074445610- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Cannabis and Cannabinoid Research
- Barrier Structure and Function Studies
- Graphene and Nanomaterials Applications
- MicroRNA in disease regulation
- Advancements in Battery Materials
- Advanced biosensing and bioanalysis techniques
- Coenzyme Q10 studies and effects
- Glioma Diagnosis and Treatment
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced battery technologies research
- Biochemical and Structural Characterization
- Immune Cell Function and Interaction
- Infant Nutrition and Health
- Extracellular vesicles in disease
- Alzheimer's disease research and treatments
- Pancreatic function and diabetes
- CAR-T cell therapy research
- Antimicrobial Peptides and Activities
- Streptococcal Infections and Treatments
- PARP inhibition in cancer therapy
- Free Radicals and Antioxidants
The University of Queensland
2019-2025
The prognosis of brain cancers such as glioblastoma remains poor despite numerous advancements in the field neuro-oncology. presence blood barrier (BBB) along with highly invasive and aggressive nature presents a difficult challenge for developing effective therapies. Temozolomide (TMZ) is first line agent used clinic it has been useful increasing patient survival rates. However, TMZ suffers from issues related to its pharmacokinetics, short plasma half-life (2 h), subjected P-gp efflux,...
Resveratrol (RES) is a naturally existing polyphenol which exhibits anti-oxidant, anti-inflammatory, and anti-cancer properties. In recent years, RES has attracted attention for its synergistic effect with other drugs the treatment of drug resistant cancers. However, faces issues poor pharmacokinetics, stability low solubility limits clinical application. present study, been loaded onto uniformly sized (~60 nm) mesoporous silica nanoparticles (MSNs) to improve in vitro anti-proliferative...
The blood brain barrier (BBB) and tumour (BTB) remain a major roadblock for delivering therapies to treat cancer. Amongst cancers, glioblastoma (GBM) is notoriously difficult due the challenge of chemotherapeutic drugs across BBB into microenvironment. Consequently, GBM has high rates recurrence. Currently, limited numbers chemotherapies are available that can cross GBM. Nanomedicine an attractive solution treating as it augment drug penetration heterogeneous site. However, very few...
Glioblastoma (GBM) is an aggressive malignancy of the central nervous system (CNS) that remains incurable despite multitude improvements in cancer therapeutics. The conventional chemo and radiotherapy post-surgery have only been able to improve prognosis slightly; however, development resistance and/or tumor recurrence almost inevitable. There a pressing need for adjuvant molecular therapies can successfully efficiently block progression. During last few decades, non-coding RNAs (ncRNAs)...
Coenzyme Q10 is a potent antioxidant that plays an important role in the maintenance of various biochemical pathways body and has wide range therapeutic applications. However, it low aqueous solubility oral bioavailability. Mesoporous silica nanoparticles (MCM-41 SBA-15 types) exhibiting varying pore sizes modified with phosphonate amino groups were used to study influence structure surface chemistry on solubility, vitro release profile, intracellular ROS inhibition activity coenzyme Q10....
Cannabidiol (CBD) is a non-neurotoxic, phytocannabinoid from cannabis with reported medicinal properties, including antiepileptic and anti-inflammatory activity. Several in vitro vivo studies have shown that CBD has antitumor potential against colorectal cancer (CRC), the third deadliest world. However, as different mutations influence effects can bind variety of receptors, it yet to be determined whether specific CRC affect CBD's efficacy treatment CRC. To investigate this, we selected four...
Nanoparticle based permeation enhancers have the potential to improve oral delivery of biologics. Recently, solid silica nanoparticles were discovered intestinal permeability peptides and proteins via transient opening gut epithelium. In this study, we developed small-sized (∼60 nm) virus-like (VSNP) as a reversible next generation non-toxic enhancer for Our results show that anionic VSNP showed better permeation-enhancing effect than same sized spherical Stöber by enhancing apparent insulin...
This study aimed to develop synergistic therapies treat superbug infections through the encapsulation of sortase A inhibitors (SrtAIs; trans-chalcone (TC), curcumin (CUR), quercetin (QC), or berberine chloride (BR)) into MCM-41 mesoporous silica nanoparticles (MSNs) a phosphonate-modified analogue (MCM-41-PO3-) overcome their poor aqueous solubility. resazurin-modified minimum inhibitory concentration (MIC) and checkerboard assays, measure SrtAI synergy in combination with leading...
Coenzyme-Q10 (CoQ10) is a hydrophobic benzoquinone with antioxidant and anti-inflammatory properties. It known to reduce oxidative stress in various health conditions. However, due the low solubility, permeability, stability, poor oral bioavailability, dose of CoQ10 required for desired therapeutic effect very high. In present study, encapsulated into two milk derived proteins β-lactoglobulin lactoferrin (BLG LF) produce self-assembled nanostructures around 100–300 nm high encapsulation...
The presence of the blood-brain barrier (BBB) limits delivery therapies into brain. There has been significant interest in overcoming BBB for effective to Inorganic nanomaterials, especially silica nanoparticles with varying surface chemistry and topology, have recently used as permeation enhancers oral protein delivery. In this context, sizes chemistries employed overcome barrier; however, there is no report examining effect nanoscale roughness on permeability. This paper reports influence...