A5029842907- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Phytochemicals and Antioxidant Activities
- COVID-19 Clinical Research Studies
- Drug Solubulity and Delivery Systems
- Neutropenia and Cancer Infections
- Dendrimers and Hyperbranched Polymers
- Antibiotic Resistance in Bacteria
- Salmonella and Campylobacter epidemiology
- Advanced biosensing and bioanalysis techniques
- Bacterial Identification and Susceptibility Testing
- Viral gastroenteritis research and epidemiology
- Berberine and alkaloids research
- Natural Antidiabetic Agents Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Natural product bioactivities and synthesis
- Antibiotics Pharmacokinetics and Efficacy
- Surfactants and Colloidal Systems
- Gallbladder and Bile Duct Disorders
- Infection Control in Healthcare
- Free Radicals and Antioxidants
- Hepatitis B Virus Studies
Jiangsu University
2016-2024
Shaukat Khanum Memorial Cancer Hospital and Research Center
2016-2024
Fudan University
2023-2024
The University of Queensland
2019-2023
Khwaja Fareed University of Engineering and Information Technology
2023
World Health Organization
2020-2022
Public Health Foundation of India
2020
Medical Research Council
2020
Indian Council of Medical Research
2020
University of Oxford
2020
BackgroundWorld Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs — remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a in patients hospitalized with coronavirus disease 2019 (Covid-19).MethodsWe randomly assigned inpatients Covid-19 equally between one the trial drug regimens that was locally available open control (up to five options, active local standard care). The intention-to-treat primary analyses examined in-hospital...
Extracellular vesicles (EVs) occur in a variety of bodily fluids and have gained recent attraction as natural materials due to their bioactive surfaces, internal cargo, role intercellular communication. EVs contain various biomolecules, including surface cytoplasmic proteins; nucleic acids that are often representative the originating cells. can transfer content other cells, process is thought be important for several biological processes, immune responses, oncogenesis, angiogenesis. An...
The prognosis of brain cancers such as glioblastoma remains poor despite numerous advancements in the field neuro-oncology. presence blood barrier (BBB) along with highly invasive and aggressive nature presents a difficult challenge for developing effective therapies. Temozolomide (TMZ) is first line agent used clinic it has been useful increasing patient survival rates. However, TMZ suffers from issues related to its pharmacokinetics, short plasma half-life (2 h), subjected P-gp efflux,...
This review highlights the transformative impact of microfluidic technology on personalized drug delivery. Microfluidics addresses issues in traditional synthesis, providing precise control and scalability nanoparticle fabrication, platforms show high potential for versatility, offering patient-specific dosing real-time monitoring capabilities, all integrated into wearable technology. Covalent conjugation antibodies to nanoparticles improves bioactivity, driving innovations targeting. The...
Glioblastoma is an incurable cancer with a 5-year survival chance of less than 5%. Chemotherapy therapeutic approach to treating the disease; however, due presence blood-brain barrier (BBB), probability success low. To overcome this issue, nanoparticles are promising carriers for crossing BBB and delivering drugs tumor. In study, anticancer efficacy doxorubicin (DOX) carboplatin (CB) loaded into polyethylene glycol (PEG)ylated liposome (PEG-Lip) in brain was evaluated vitro vivo. The results...
Human skin is the largest organ and outermost surface of human body, due to continuous exposure various challenges, it prone develop injuries, customarily known as wounds. Although tissue engineering strategies bioactive wound matrices have been employed speed up healing, scarring remains a significant challenge. The environment harsh presence degradative enzymes elevated pH levels, physiological processes involved in regeneration operate on distinct time scales. Therefore, there need for...
Metal-organic frameworks (MOFs) offer innovative solutions to the limitations of traditional oral drug delivery systems through their unique combination metal ions and organic ligands. This review systematically examines structural properties principles MOFs, setting stage for application in delivery. It discusses various classes including those based on zirconium, iron, zinc, copper, titanium, aluminum, potassium, magnesium, assessing drug-loading capacities, biocompatibility, controlled...
This study aimed to evaluate the therapeutic efficacy of cisplatin encapsulated into polybutylcyanoacrylate (PBCA) nanoparticles for treatment kidney cancer. The nanoformulation was successfully developed using miniemulsion polymerization method and characterized in terms size, size distribution, drug loading encapsulation efficiencies, release behavior, vitro cytotoxicity effects, vivo toxicity, effects. Cisplatin-loaded PBCA were confirmed be nanoscale with entrapment efficiency 23%...
Stems are the important residues of Trapa quadrispinosa Roxb., which abundant in phenolic compounds. Ultrasonic-assisted enzymatic extraction (UAEE) is confirmed as a novel technology with main advantages enhancing yield and physiological activities extracts from various plants. In this study, UAEE was applied to obtain highest content, strongest antioxidant, antitumor optimize conditions using response surface methodology (RSM). The stems T. were characterized by determination their...
Rattan tea is a medicinal plant that has been used for many years the treatment of inflammation, fatty liver, tumor, diabetes, and hyperlipidemia.A green novel approach based on surfactant-mediated, ultrasonic-assisted extraction (SM-UAE) was developed antioxidant polyphenols from tea. A nonionic surfactant Tween-80 selected as solvent. The activity measured by total phenolic content (TPC) ferric-reducing/antioxidant capacity (FRAC) assay.Optimization parameters including concentration...
Meropenem (MER) is an effective broad-spectrum antibiotic currently only available in the parenteral form requiring frequent drug preparation and administration due to its extremely poor stability. The unavailability of oral primarily ultrapoor handling processing stability, hydrophilic nature that inhibits passive diffusion across gastrointestinal (GI) epithelium, degradation harsh gastric environment, GI expulsion through enterocyte efflux glycoproteins. In this regard, we have developed...