A5055712656- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Cell Adhesion Molecules Research
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Nanoparticles: synthesis and applications
- Trace Elements in Health
- Cardiovascular Disease and Adiposity
- Blood properties and coagulation
- Nanocluster Synthesis and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- 3D Printing in Biomedical Research
- Advanced MRI Techniques and Applications
- Phagocytosis and Immune Regulation
- Atherosclerosis and Cardiovascular Diseases
- Microfluidic and Bio-sensing Technologies
- Medical Imaging Techniques and Applications
- Bone and Dental Protein Studies
- S100 Proteins and Annexins
- Galectins and Cancer Biology
- Mesenchymal stem cell research
- Coenzyme Q10 studies and effects
- Ultrasound and Hyperthermia Applications
Griffith University
2021-2025
The University of Queensland
2017-2021
Brisbane School of Theology
2018
Reactive oxygen species (ROS) and reactive nitrogen (RNS) are key signaling molecules that play an important role in the inflammation progression of many diseases such as cardiovascular disease, especially atherosclerosis. ROS particular a significant factor development rheumatoid arthritis other autoimmune allergies. In this study, novel Fe3O4/CeO2 core-shell theranostic nanoparticles capable reacting with being detected by MRI were synthesized thoroughly characterized. vitro studies,...
Abstract Thrombosis and its complications are responsible for 30% of annual deaths. Limitations methods diagnosing treating thrombosis highlight the need improvements. Agents that provide simultaneous diagnostic therapeutic activities (theranostics) paramount an accurate diagnosis rapid treatment. In this study, silver‐iron oxide nanoparticles (AgIONPs) developed highly efficient targeted photothermal therapy imaging thrombosis. Small iron employed as seeding agents generation a new class...
19F magnetic resonance imaging (MRI) is a powerful noninvasive technique that shows tremendous potential for the diagnosis and monitoring of human diseases. Fluorinated compounds are commonly used as MRI contrast agents to develop "hot spot" imaging. To achieve high-resolution MR images, high density nuclei required in agents. However, because inherent hydrophobicity fluorinated moieties, aggregation with fluorine content often observed aqueous solution, resulting attenuated signal low...
Reactive oxygen species (ROS) play an essential role in the progression of many chronic diseases like atherosclerosis and rheumatoid arthritis. For decades, antioxidant compounds have always been considered as potential treatments for these ROS-related diseases. Concomitantly, noninvasive imaging systems such magnetic resonance (MRI) also widely used diagnosis diseases, especially atherosclerosis. In this study, we investigated feasibility to develop chitosan nanococktails containing both...
MRI<italic>T</italic><sub>1</sub>/<italic>T</italic><sub>2</sub>switchable nanosensor discriminates thrombus age by exhibiting a<italic>T</italic><sub>1</sub>signal on fresh while showing a<italic>T</italic><sub>2</sub>signal aged thrombus. The is also labelled with 5-TAMRA for optical imaging.
Thrombosis is a major concern worldwide as thrombosis-related deaths are attributed to one in five globally. Establishing clot-targeting theranostic particle for diagnosis and treatment of thrombosis related diseases crucial provide rapid life-saving intervention. Herein, we developed activated platelet targeted gold-iron oxide nanoparticles (AuIONP) robust powerful probe facilitating triple imaging modalities, including magnetic resonance (MRI), photoacoustic (PAI), fluorescence (FLI)....
This study aims to compare the relaxivities of ultra-small dual positive and negative contrast iron oxide nanoparticles (DCION) at different magnetic field strengths ranging from 4.7 16.4 T physiological temperatures; investigate effect particle aggregation on relaxivities. Relaxivities DCIONs were determined by resonance imaging scanners 4.7, 7, 9.4, T. Both longitudinal (T1) transverse relaxation times (T2) measured appropriate spin-echo sequences. It has been found that both are...
Overproduction of reactive oxygen species (ROS) is commonly known as a key factor in the progression many chronic inflammation diseases such atherosclerosis and rheumatoid arthritis. In this study, metal oxide nanodot-coated layered double hydroxide (LDH) nanocomposite constructed for theranostics ROS-related diseases. This first time that both cerium iron nanoparticles (NPs) were attached on surface LDH NPs through electrostatic interaction via nanoengineering approach. LDHs served...
We have developed a novel pH-responsive delivery system consisting of oleylamine-modified polysuccinimide (PSI) nanoparticles (NPs) whereby NPs remained stable and started to release bioactive agents after 8.5 h with maximal acquired 36 under physiological pH. Our did not exhibit any burst drug, which is key advantage in anti-cancer targeted drug system. Here, the function as carrier for such Curcumin IR-780 dye former exerts its intrinsic abilities, latter confers photothermal treatment...
Nanophotothermal therapy based on nanoparticles (NPs) that convert near-infrared (NIR) light to generate heat selectively kill cancer cells has attracted immense interest due its high efficacy and being free of ionizing radiation damage. Here, for the first time, we have designed a novel nanohybrid, silver-iron oxide NP (AgIONP), which was successfully tuned strong absorbance at NIR wavelengths be effective in photothermal treatment dual-imaging strategy using MRI photoacoustic imaging (PAI)...
We have for the first time reported 120 nm silver/iron oxide hybrid nano-popcorns with surface plasmon resonance tuned at near-infrared (NIR) range imaging and therapeutic applications. The displayed excellent photothermal thrombolytic effect anticancer activity in a concentration-dependent manner upon NIR laser irradiation, benefiting treatment of thrombosis cancer. At low concentrations, exhibited relatively good reactive oxygen species (ROS) scavenging capability. Notably, exerted...
Monocyte recruitment and transmigration are crucial in atherosclerotic plaque development. The multi-disease complexities aggravate the situation continue to be a constant concern for understanding atherosclerosis Herein, 3D hydrogel-based model that integrates disease-induced microenvironments is sought designed, allowing us explore early stages of atherosclerosis, specifically examining monocyte fate complexities. As proof-of-concept study, murine cells employed develop model. constructed...
We explored the feasibility of a self-assembled chitosan nanocomposite incorporating cerium oxide/nanoceria and superparamagnetic iron oxide nanoparticles (Chit-IOCO NPs), conjugated with methotrexate (MTX) Cy5 dye, as an integrated cancer theranostic nanosystem (Chit-IOCO-MTX-Cy5). In this system, nanoceria serves anti-cancer agent, while function negative contrast agent for MR imaging. This dual metal is MTX which structural analogue folate, serving both targeting mechanism folate...
SCE5-AgIONPs, specifically targets thrombi in both vitro and vivo models of thrombosis. SCE5-AgIONPs can be activated by ultrasound, resulting a restoration blood flow with no detectable toxicity. Created BioRender.com.
The manipulation of micro and nanoparticles has extensive applications in biomedical research, clinical diagnostics, environmental monitoring, drug discovery, the mining industry. Dielectrophoresis (DEP) utilises nonuniform electric fields to manipulate particles, offering a label-free, high-precision, non-invasive method for both natural synthetic particles. DEP been well studied Stokes flow region with ultra-low Reynolds numbers (Re ≪ 1), where viscous effects dominate. However, its...