The adsorption capability of Ni/Al LDH modified with gambier leaf extract was evaluated for the removal Rhodamine B (RhB), Malachite Green (MG), and Methylene Blue (MB) dyes from aqueous solutions. UV-Vis spectroscopy analysis revealed that Ni/Al-Gambier Leaf Extract exhibited a higher efficiency in cationic dye compared to unmodified LDH. percentages RhB, MG, MB using were 6.00%, 40.05%, 14.73%, respectively. However, after modification Gambier Extract, these values significantly improved...

Thrombosis is a major concern worldwide as thrombosis-related deaths are attributed to one in five globally. Establishing clot-targeting theranostic particle for diagnosis and treatment of thrombosis related diseases crucial provide rapid life-saving intervention. Herein, we developed activated platelet targeted gold-iron oxide nanoparticles (AuIONP) robust powerful probe facilitating triple imaging modalities, including magnetic resonance (MRI), photoacoustic (PAI), fluorescence (FLI)....

Application of natural compounds in the field nanoparticle synthesis have been explored due to their robust application and safety. Additionally, these exhibit activities which can be utilised for medicinal purposes. One most useful is catechin, a polyphenolic compound present high concentration Uncaria gambir. Herein, we developed inorganic nanoparticles (NPs) based on green with gambir extract (GE) produce iron oxide (GE-IONP), gold (GE-AuNP) silver (GE-AgNP). These were then subjected...

Preparation of SNEDDS aims to improve solubility and absorption furosemide in the body reduce dosage minimize side effects drugs. Ternary diagram constructed from composition mixture produced nanoemulsion range 20-40% capryol-90, polysorbate-80 40-60% PEG-400. Formulations using Design-Expert ® 10 with simplex-lattice-design method study was aimed investigate effect each component's proportions towards test responses. Emulsification time, drug content viscosity were best demonstrated by...

Alzheimer’s Disease (AD), the most common form of dementia continues to be deadliest neuro degenerative disease in recent years. Despite significant efforts mitigate progression disease, there is no known cure and development towards a more effective treatment still lacking. AD marked by exceptionally low amount acetylcholine brain, formation tau protein, amyloid beta plaque. Current drugs choice for treating AD, namely donepezil memantine, are acetylcholinesterase (AChE) inhibitors which...

Erythromycin, a macrolide antibiotic is classified into Biopharmaceutical Classification System (BCS) class II which has low solubility in water. The corresponds to the bioavailability blood. One strategy increase of Erythromycin formulation erythromycin nanoemulsion. This research aims form nanoemulsion using PIT (Phase Transition Temperature) method for obtaining optimum formula virgin coconut oil (VCO) can be found with varying concentrations Tween 80 surfactant and PEG 400 cosurfactant....

A NiFe layered double hydroxide (LDH) composite with Uncaria gambir (UG) leaf extract was successfully synthesized. The (NiFe-UG LDH) and the base material (NiFe were identified using X-ray Diffraction (XRD), Fourier Transform Infra Red (FTIR), Brunauer-Emmett-Teller (BET) Surface Area techniques. XRD FTIR results revealed incorporation of gambier into LDH structure, as indicated by combined diffraction patterns spectral features. BET analysis a decrease in surface area NiFe-UG compared to...

Ekstrak etanol daun petai (EDP) mengandung senyawa flavonoid, tanin, dan terpen yang berkhasiat untuk terapi tukak lambung. Formulasi sediaan gastroretentif EDP sistem gastrorentif bertujuan memperlama waktu tinggal obat di lambung sehingga meningkatkan bioavalabilitas menggunakan polimer HPMC-K4M Kitosan. Penelitian ini berujuan mengetahui interaksi kimia antara kitosan dengan ekstak. Preparasi dilakukan granulasi basah perbedaan konsentrasi F1 (10% : 5%), FA (25% FB 20%), FAB 20%)....

Mefenamic acid as pain relief drug belongs to the biopharmaceutics classification system (BCS) class II which is practically insoluble in water causing extremely low dissolution gastrointestinal tract. The self nanoemulsifying delivery (SNEDDS) a new innovation pharmaceutical dosage form that has effectively known increase solubilization of hydrophobic polar solvent. In this study capryol-90 was selected oil phase SNEDDS it showed maximal solubility mefenamic (20 mg/mL). Combination...

Parkia speciosa (petai) pods are rarely used and considered as waste despite their phenolic flavonoid content. Phenolic content in plants known to exhibit antioxidant activity. Antioxidants potentially act agains radical mediate the damage by structural stabilization. This research was conducted analyze potential of petai using DPPH method. Analysis showed IC50 ethanolic extract 75.72 ppm, which indicate strong acting antioxidant. Standardization extracts were determined manage quality...

Preparation of mucoadhesive patch film containing Virgin Coconut Oil (VCO) has been made as a medium to inhibit the growth Streptococcus mutans . This research was conducted make which meets standard physical characteristic film. The is weight uniformity, thickness, folding endurance resistance, swelling index and pH solution. presence fatty acids trapped in analyzed with Gas Chromatography Mass Spectrometry (GC-MS). result showed that uniformity value weights ranging from 0.04 0.17 g....

Catalyst (NH4)6[b-P2W18O62]/Ta has been synthesized by simple wet impregnation at 30-40 °C under atmospheric conditions using Dawson type polyoxometalate (NH4)6[b-P2W18O62] and tantalum. The catalyst was characterized FTIR spectrophotometer, XRD, SEM, N2 adsorption desorption methods. spectrum of showed that Ta successfully impregnated which indicated vibration wavenumber 900-1100 cm-1 for 550 Ta. surface area the after higher than (NH4)6[b-P2W18O62]•nH2O its morphology found to be uniform....

Preparation of petai pods extract (Parkia speciosa) into ethosome aim to increased penetration through the skin. The method cold is used in preparing encapsulation by with variation concentration soya lecithin, propylene glycol, and ethanol. proportion optimum formula consisted were 0,2 g 1 ml 4 ethanol that response values obtained pH 4,74, viscosity 0,950 cP, %EE 74,326%, stability 7,288%. resulted PDI 0,23, zeta potential -7,5 mV, particle size 818,7 nm. Ethosome showed spheric using...

Context: Parkia speciosa is a species which contains hydrophilic compounds such as flavonoids and phenolics. These are difficult to penetrate lipophilic biological membranes. Transfersome targeted dosage form that can overcome the limitations of phytomedicine. Aims: To improve ability extracts Methods: was formulated with soya lecithin Tween-80 independent variables using factorial design 32. The influence factor compositions interactions on transfersome characteristics observed based...

12-Tungstophosphoric acid H3[a-PW12O40] was impregnated with silica to form 12-tungstophosphoric acid/silica catalyst. Structural properties of catalyst were characterized using Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and nitrogen adsorption desorption. The results showed that into increasing surface area properties. catalytic activity under mild condition from after impregnation slightly increased compared to original structure reaction...

Telah dilakukan penelitian mengenai formulasi dan evaluasi sediaan submikro partikel gelasi inonik pembawa ekstrak Beluntas (Pluchea indica L) sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui efektivitas anti bakteri terhadap Staphylococcus aureus dengan melihat penurunan jumlah diameter abses pada kulit tikus putih jantan galur wistar. Preparasi daun beluntas menjadi menggunakan polimer kitosan natrium alginat serta kalsium klorida (CaCl2) sebanyak 40 mL konsentrasi 18 mM...

Oxidation of cyclohexane to cyclohexanol and cyclohexanone was carried out using H4[a-SiW12O40]/TiO2 as catalyst. In the first experiment, catalyst synthesized characterized FTIR spectroscopy X-Ray analysis. second applied for conversion cyclohexane. The monitored GC GCMS. results showed that successfully 1 g H4[a-SiW12O40] 0.5 TiO2. spectrum vibration appeared at 771-979 cm-1 TiO2 520-680 cm-1. XRD powder pattern analysis indicated crystallinity still remained after impregnation form...

Adipic acid production through catalytic conversion of cyclohexanol-cyclohexanone using polyoxometalate H 5 [ a -BW 12 O 40 ] and 4 -SiW as catalysts was carried out systematically. Polyoxometalates were synthesized an inorganic synthesis method characterized Fourier transform infrared spectroscopy (FTIR). formed from by melting point measurement, identification functional group FTIR spectrophotometer, analysis gas chromatography-mass spectrometry (GC-MS), 1 13 C NMR (nuclear magnetic...

Glibenclamide has the biopharmaceutics classification system (BCS) class II which high permeability and low solubility. The solubility of glibenclamide can be enhanced by forming solid lipid nanoparticles (SLN). This research aim to prepare characterize SLN loading glibenclamide. formula was composed using liquid as virgin coconut oil (VCO), PEG 6000 a matrix, tween 80 with various concentrations stabilizer, 400 co-surfactant. Characterization conducted determining encapsulation efficiency...

A study regarding ionic-gelation submicron particle of papaya leaves (Carica L.) extract with lactic acid weeds potentially for antidiarrhea has been conducted. Preparation ethanolic and isolate into particles was done by ionic gelation method. This aimed to determine: the major compound extract, total quercertine percent value encapsulation efficiency optimum formula which varied (CaOH)2 three formulas, physical properties particles. Formula 1 using 12.5 gram; 2 17,5 3 22.5 gram. The...