A5019943693- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Trace Elements in Health
- Nanoparticle-Based Drug Delivery
- Radiopharmaceutical Chemistry and Applications
- Inflammatory mediators and NSAID effects
- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- 3D Printing in Biomedical Research
- Barrier Structure and Function Studies
- Drug Transport and Resistance Mechanisms
- Field-Flow Fractionation Techniques
- Graphene and Nanomaterials Applications
- Advanced Electron Microscopy Techniques and Applications
- Marine Biology and Ecology Research
- Methane Hydrates and Related Phenomena
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Advancements in Battery Materials
- Polymer Surface Interaction Studies
- Nanoplatforms for cancer theranostics
- Ion channel regulation and function
- Cell Adhesion Molecules Research
- Microbial Community Ecology and Physiology
UNSW Sydney
2016-2024
Cancer Institute of New South Wales
2018-2024
Children's Cancer Institute Australia
2020-2022
Abstract Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poorly understood. Here we show that intratumoral copper levels influence cancer cells. Deep analysis The Cancer Genome Atlas database and tissue microarrays showed strong correlation between major influx transporter (CTR-1) across many cancers but not...
The prognosis of brain cancers such as glioblastoma remains poor despite numerous advancements in the field neuro-oncology. presence blood barrier (BBB) along with highly invasive and aggressive nature presents a difficult challenge for developing effective therapies. Temozolomide (TMZ) is first line agent used clinic it has been useful increasing patient survival rates. However, TMZ suffers from issues related to its pharmacokinetics, short plasma half-life (2 h), subjected P-gp efflux,...
The blood brain barrier (BBB) and tumour (BTB) remain a major roadblock for delivering therapies to treat cancer. Amongst cancers, glioblastoma (GBM) is notoriously difficult due the challenge of chemotherapeutic drugs across BBB into microenvironment. Consequently, GBM has high rates recurrence. Currently, limited numbers chemotherapies are available that can cross GBM. Nanomedicine an attractive solution treating as it augment drug penetration heterogeneous site. However, very few...
Nanoparticles hold great preclinical promise in cancer therapy but continue to suffer attrition through clinical trials. Advanced, three dimensional (3D) cellular models such as tumor spheroids can recapitulate elements of the environment and are considered superior model evaluate nanoparticle designs. However, there is an important need better understand penetration kinetics determine how different cell characteristics may influence this uptake. A key challenge with current approaches for...
Polymeric micelles have been extensively studied as vectors for the delivery of hydrophobic drugs treatment cancers and other diseases. Despite intensive research, few formulations provide significant benefits, even fewer clinically approved. While many traditional non-responsive excellent safety profiles, they lack ability to respond intracellular environment release their cargo in a spatiotemporally defined manner effectively deliver large doses cytotoxic into cytosol cells that overwhelm...
Given the strong clinical evidence that copper levels are significantly elevated in a wide spectrum of tumors, homeostasis is considered as an emerging target for anticancer drug design.Monitoring vivo therefore paramount importance when assessing efficacy copper-targeting drugs.Herein, we investigated activity compound Dextran-Catechin by developing [ 64 Cu]CuCl2 PET imaging protocol to monitor its effect on tumors.Methods: Protein expression transporter 1 (CTR1) tissue microarrays...
A key challenge in nanomedicine stems from the continued need for a systematic understanding of delivery nanoparticles live cells. Complexities are often influenced by biophysical characteristics nanoparticles, where even subtle changes to nanoparticle designs can alter cellular uptake, transport and activity. Close examination these processes, especially with imaging, offers important insights that aid future design or translation. Rapid fluorescence lifetime imaging microscopy (RapidFLIM)...
<p>Methods for Master Regulator Analysis</p>
<p>TEPA increases tumor-infiltrating immune cells in Th-MYCN mice</p>
<p>Effect of copper levels on EGFR phosphorylation and PD-L1 protein stability</p>
<p>TEPA did not affect tumor growth in an immunocompromised neuroblastoma xenograft model</p>
<p>Copper lowering drugs increased NK-mediated cell death in vitro</p>
<p>Effect of copper levels on PD-L1 expression and interferon stimulation in cancer cells</p>
<p>Co-expression plots of VST-normalized gene expression profiles derived from TCGA datasets for PD-L1 and four copper-responsive genes</p>
<p>DC increases tumor-infiltrating immune cells in Th-MYCN mice</p>
<p>TEPA increases tumor-infiltrating immune cells in Th-MYCN mice</p>
<p>TEPA did not affect tumor growth in an immunocompromised neuroblastoma xenograft model</p>
<p>Copper lowering drugs increased NK-mediated cell death in vitro</p>
<p>Methods for Master Regulator Analysis</p>
<p>Effect of copper levels on PD-L1 expression and interferon stimulation in cancer cells</p>
<p>DC increases tumor-infiltrating immune cells in Th-MYCN mice</p>
<p>Effect of copper levels on EGFR phosphorylation and PD-L1 protein stability</p>