A5034113263- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- Toxin Mechanisms and Immunotoxins
- Trace Elements in Health
- Nutrition and Health in Aging
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Radiopharmaceutical Chemistry and Applications
- Body Composition Measurement Techniques
- Transgenic Plants and Applications
- interferon and immune responses
- Immune cells in cancer
- COVID-19 Clinical Research Studies
- Neuroblastoma Research and Treatments
- Plant tissue culture and regeneration
- Single-cell and spatial transcriptomics
- Pharmacological Effects and Toxicity Studies
- Inflammatory mediators and NSAID effects
- Ferroptosis and cancer prognosis
- Drug Transport and Resistance Mechanisms
- Sarcoma Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Gene Regulatory Network Analysis
- Histone Deacetylase Inhibitors Research
University of Bologna
2015-2024
Magna Graecia University
2021
Istituto Ortopedico Rizzoli
2017-2020
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2020
Policlinico S.Orsola-Malpighi
2017
March of Dimes
2013
University of Modena and Reggio Emilia
2012
University of Palermo
2012
University of Messina
2012
University of Udine
2012
The novel respiratory disease COVID-19 has reached the status of worldwide pandemic and large efforts are currently being undertaken in molecularly characterizing virus causing it, SARS-CoV-2. genomic variability SARS-CoV-2 specimens scattered across globe can underly geographically specific etiological effects. In present study, we gather 48,635 complete genomes available thanks to collection endeavor GISAID consortium thousands contributing laboratories. We analyzed annotated all mutations...
Abstract Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poorly understood. Here we show that intratumoral copper levels influence cancer cells. Deep analysis The Cancer Genome Atlas database and tissue microarrays showed strong correlation between major influx transporter (CTR-1) across many cancers but not...
The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and global effort is being undertaken to characterize molecular features evolutionary origins this virus. In paper, we set out shed light on SARS-CoV-2/host receptor recognition, crucial factor for successful virus infection. Based current knowledge interactome between host cell proteins, performed Master Regulator Analysis detect which...
Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have emerged, posing a renewed threat to disease 2019 containment and vaccine drug efficacy. In this study, we analyzed more than 1,000,000 SARS-CoV-2 genomic sequences deposited up April 27, 2021, on the GISAID public repository, identified novel T478K mutation located Spike protein. The is structurally in region of interaction with human receptor ACE2 was detected 11,435 distinct cases. We show that has appeared...
The avalanche of genomic data generated from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus requires development tools to detect and monitor its mutations across world. Here, we present a webtool, coronapp, dedicated easily processing user-provided SARS-CoV-2 sequences visualizing current worldwide status mutations. webtool allows users highlight categorize them by frequency, country, location effect on protein sequences, their presence in population over time. tool...
SARS-CoV-2 entry in human cells is mediated by the interaction between viral Spike protein and ACE2 receptor. This mechanism evolved from ancestor bat coronavirus currently one of main targets for antiviral strategies. However, there exist several variants population as result mutations, it unclear if these may exert a specific effect on affinity with which, turn, also characterized multiple alleles population. In current study, GBPM analysis, originally developed highlighting host-guest...
Abstract The Monkeypox virus is the etiological cause of a recent multi-country outbreak, with nearly one hundred distinct cases detected outside endemic areas Africa in May 2022. In this article, we analyze sequences two full genomes from Portugal and Belgium, compare them all available sequences, annotated by year geographic origin, as well related Cowpox Variola (smallpox) sequences. Our results show that outbreak most likely originating West African clade Monkeypox, >99% sequence...
The Mpox (formerly named Monkeypox) virus is the etiological cause of a recent multi-country outbreak, with thousands distinct cases detected outside endemic areas Africa as December 2023. In this article, we analyze sequences full genomes from Europe and compare them all available historical relevance, annotated by year geographic origin, well related Cowpox Variola (smallpox) sequences. Our results show that outbreak most likely originating West African clade Mpox, >99 % sequence identity...
Gene network inference and master regulator analysis (MRA) have been widely adopted to define specific transcriptional perturbations from gene expression signatures. Several tools exist perform such analyses but most require a computer cluster or large amounts of RAM be executed.We developed corto, fast lightweight R package infer networks MRA data, with optional corrections for copy-number variations able run on signatures generated RNA-Seq ATAC-Seq data. We extensively benchmarked it...
Stenodactylin is a highly toxic plant lectin purified from the caudex of Adenia stenodactyla, with molecular structure, intracellular routing and enzyme activity similar to those ricin, well-known type 2 ribosome-inactivating protein. However, in contrast stenodactylin retrogradely transported not only peripheral nerves but also central nervous system.Stenodactylin properties make it potential candidate for application neurobiology experimental therapies against cancer. Thus, necessary...
The current outbreak of COVID-19 has generated an unprecedented scientific response worldwide, with the generation vast amounts publicly available epidemiological, biological and clinical data. Bioinformatics scientists have quickly produced online methods to provide non-computational users opportunity analyzing such In this review, we report results effort, by cataloguing currently most popular web tools for research analysis. Our focus was driven on drawing data from fields epidemiology,...
Metastatic cancer cells exploit Epithelial-mesenchymal-transition (EMT) to enhance their migration, invasion, and resistance treatments. Recent studies highlight that elevated levels of copper are implicated in progression metastasis. Clinical trials using chelators associated with improved patient survival; however, the molecular mechanisms by which depletion inhibits tumor metastasis poorly understood. This remains a major hurdle clinical translation chelators. Here, we propose chelation...
The aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue bone mass, a wide range specific inflammatory adipose-related in healthy elderly Europeans.A whole-body dual-energy X-ray absorptiometry (DXA) scan made 1121 (65-79 years) women men from five European countries "New dietary strategies addressing needs population aging Europe" project (NCT01754012) cohort measure mass. Pro-inflammatory (IL-6, IL-6Rα, TNF-α,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease, 2019; COVID-19) is associated with adverse outcomes in patients. It has been observed that lethality seems to be related the age of While ageing extensively demonstrated accompanied by some modifications at gene expression level, a possible link COVID-19 manifestation still need investigated molecular level.
Abstract the recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 and causing respiratory tract disease COVID-19 has reached worldwide resonance global effort is being undertaken to characterize molecular features evolutionary origins this virus. In paper, we set out shed light on SARS-CoV-2/host receptor recognition, crucial factor for successful virus infection. Based current knowledge interactome between host cell proteins, performed Master Regulator Analysis detect...
The novel respiratory disease COVID-19 has reached the status of worldwide pandemic and large efforts are currently being undertaken in molecularly characterizing virus causing it, SARS-CoV-2. genomic variability SARS-CoV-2 specimens scattered across globe can underly geographically specific etiological effects. In present study, we gather 10,014 complete genomes available thanks to collection endeavor GISAID consortium thousands contributing laboratories. We analyze annotate all mutations...