A5078014365- Cellular Mechanics and Interactions
- Amyotrophic Lateral Sclerosis Research
- Cancer Cells and Metastasis
- Microbial Community Ecology and Physiology
- Polar Research and Ecology
- Nerve injury and regeneration
- Metastasis and carcinoma case studies
- Genomics and Phylogenetic Studies
- Prion Diseases and Protein Misfolding
- Alzheimer's disease research and treatments
- Endoplasmic Reticulum Stress and Disease
- Signaling Pathways in Disease
- 3D Printing in Biomedical Research
- Genetic Neurodegenerative Diseases
- Neurogenesis and neuroplasticity mechanisms
- Muscle Physiology and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Nuclear Receptors and Signaling
- Cell Image Analysis Techniques
- Cardiomyopathy and Myosin Studies
- Microtubule and mitosis dynamics
- Inflammasome and immune disorders
- Axon Guidance and Neuronal Signaling
UNSW Sydney
2013-2023
National Imaging Facility
2019-2022
Metastatic cancer cells exploit Epithelial-mesenchymal-transition (EMT) to enhance their migration, invasion, and resistance treatments. Recent studies highlight that elevated levels of copper are implicated in progression metastasis. Clinical trials using chelators associated with improved patient survival; however, the molecular mechanisms by which depletion inhibits tumor metastasis poorly understood. This remains a major hurdle clinical translation chelators. Here, we propose chelation...
Abstract Sphingosine 1‐phosphate (S1P) is an essential lipid metabolite that signals through a family of five G protein‐coupled receptors, S1PR1‐S1PR5, to regulate cell physiology. The multiple sclerosis drug Fingolimod (FTY720) potent S1P receptor agonist causes peripheral lymphopenia. Recent research has demonstrated direct neuroprotective properties FTY720 in several neurodegenerative paradigms; however, the native ligand have not been established. We aimed establish significance...
ABSTRACT Inhibitory proteins, particularly Nogo 66, a highly conserved 66-amino-acid loop of A (an isoform RTN4), play key roles in limiting the intrinsic capacity central nervous system (CNS) to regenerate after injury. Ligation surface receptors (NgRs) and/or leukocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse orthologue paired B (PIRB) by 66 transduces inhibitory signals that potently inhibit neurite outgrowth. Here, we show soluble A3 (LILRA3) is high-affinity for suggesting...
Summary Candidatus Dormibacterota is an uncultured bacterial phylum found predominantly in soil that present high abundances within cold desert soils. Here, we interrogate nine metagenome‐assembled genomes ( MAGs ), including six new derived from metagenomes obtained two eastern Antarctic sites. Phylogenomic and taxonomic analyses revealed these represent four genera five species, representing order‐level clades Ca . Dormibacterota. Metabolic reconstructions of the potential for aerobic...
Genetically encoded filamentous actin probes, Lifeact, Utrophin and F-tractin, are used as tools to label the cytoskeleton. Recent evidence in several different cell types indicates that these probes can cause changes dynamics, altering morphology function. Although commonly visualise dynamics neurons, their effects on axonal dendritic has not been systematically characterised. In this study, we quantitatively analysed effect of F-tractin neuronal morphogenesis primary hippocampal neurons....
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment and no cure. Mutations in profilin 1 were identified as cause of familial ALS (fALS) 2012. We investigated the functional impact mutant expression spinal cords during mouse development. developed novel model C71G under control Hb9 promoter, targeting to α-motor neurons cord Embryos transgenic mice showed evidence significant reduction brachial nerve diameter loss Mendelian inheritance....
Tropomyosins, a family of actin-associated proteins, bestow actin filaments with distinct biochemical and physical properties which are important for determining cell shape regulating many cellular processes in eukaryotic cells. Here, we used RNA-seq to investigate the effect four tropomyosin isoforms on gene expression undifferentiated differentiated rat B35 neuroblastoma In cells, overexpression Tpm1.12, Tpm2.1, Tpm3.1, Tpm4.2 differentially regulates vast number genes, clustering into...
Abstract Copper is a trace element essential to cellular function with elevated levels implicated in cancer progression. Clinical trials using copper chelators are associated improved patient survival, however, the molecular mechanisms by which depletion inhibits tumor progression poorly understood. This remains major hurdle clinical translation of chelators. Epithelial-mesenchymal transition (EMT) often exploited malignant cells promote growth and metastasis. Transforming factor (TGF)- β...