A5061589634- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- Epilepsy research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Genomics and Phylogenetic Studies
- Endometrial and Cervical Cancer Treatments
- Cellular Mechanics and Interactions
- Acute Myeloid Leukemia Research
- RNA and protein synthesis mechanisms
- Signaling Pathways in Disease
- Nuclear Receptors and Signaling
- Machine Learning in Bioinformatics
- RNA Interference and Gene Delivery
- Retinoids in leukemia and cellular processes
- Genetic and phenotypic traits in livestock
- Protein Degradation and Inhibitors
- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
- Molecular Biology Techniques and Applications
Duke-NUS Medical School
2022
UNSW Sydney
2013-2020
Nanyang Technological University
2020
Circular RNAs (circRNAs) have been recently identified as a naturally occurring family of widespread and diverse endogenous non-coding that may regulate gene expression in mammals. They are unusually stable RNA molecules with cell type- or developmental stage-specific patterns. However, the role circRNAs pathology complex disease is entirely unknown. Here, we report specific circular transcriptome multiple system atrophy (MSA) brain determined by sequencing. Five circRNAs, namely IQCK,...
Circular RNAs (circRNAs) are a naturally occurring family of non-coding RNA that may regulate gene expression in mammals. circRNAs more stable than messenger due to their resistance exonuclease. A growing body evidence has shown the is regulated during development tissue-specific manner. CircRNAs have been implicated number cancers; however, role endometrial cancer (EC) completely unknown. Here, we report circular transcriptome specific for EC as determined by sequencing. We found overall...
The human frontal lobe has undergone accelerated evolution, leading to the development of unique features such as language and self-reflection. Cortical grey matter underlying white reflect distinct cellular compositions in lobe. Surprisingly little is known about transcriptomal landscape these regions. Here, for first time, we report a detailed profile (GM) (WM) with resolution alternatively spliced isoforms obtained using RNA-Seq approach. We observed more vigorous transcriptome activity...
Our understanding of mesial temporal lobe epilepsy (MTLE), one the most common form drug-resistant in humans, is derived mainly from clinical, imaging, and physiological data humans animal models. High-throughput gene expression studies human MTLE have potential to uncover molecular changes underlying disease pathogenesis along with novel therapeutic targets. Using RNA- small RNA-sequencing parrallel, we explored differentially expressed genes hippocampus cortex patients who had undergone...
To identify the molecular signaling pathways underlying sudden unexpected death in epilepsy (SUDEP) and high-risk SUDEP compared to control patients with epilepsy.
Long intervening non-coding RNAs (lincRNAs) are a recently discovered subclass of RNAs. LincRNAs expressed across the mammalian genome and contribute to pervasive transcription phenomenon. They display tissue-specific species-specific mode expression present abundantly in brain. Here, we report patterns oligodendrocyte maturation-associated long RNA (OLMALINC), which is highly white matter (WM) human frontal cortex compared grey (GM) peripheral tissues. Moreover, identified novel isoform...
Alternative splicing of RNA is a fundamental post-transcriptional regulatory process that leads to vast diversity proteins being translated from relatively small number genomic loci. Microexons, set very protein-coding sequences 1-17 amino acids, have only recently been recognised as an important part pre-mRNA processing. Recent studies revealed microexons can play roles in various cellular functions, protein-protein interactions and also associated with neurological diseases. This review...
Tropomyosins, a family of actin-associated proteins, bestow actin filaments with distinct biochemical and physical properties which are important for determining cell shape regulating many cellular processes in eukaryotic cells. Here, we used RNA-seq to investigate the effect four tropomyosin isoforms on gene expression undifferentiated differentiated rat B35 neuroblastoma In cells, overexpression Tpm1.12, Tpm2.1, Tpm3.1, Tpm4.2 differentially regulates vast number genes, clustering into...
Abstract Sudden unexpected death in epilepsy (SUDEP) is the leading type of epilepsy-related death. Severely depressed brain activity these cases may impair respiration, arousal, and protective reflexes, occurring as a prolonged postictal generalized EEG suppression (PGES) resulting high-risk for SUDEP. In autopsy hippocampus cortex, we observed no proteomic differences between SUDEP cases, contrasting our previously reported robust controls. Transcriptomics cortex from surgical segregated...