A5016799928- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- RNA regulation and disease
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Viral Infectious Diseases and Gene Expression in Insects
- Molecular Biology Techniques and Applications
- Advanced Biosensing Techniques and Applications
- RNA Interference and Gene Delivery
- Genomics and Phylogenetic Studies
- Immunotherapy and Immune Responses
- Neuroscience and Neuropharmacology Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Machine Learning in Bioinformatics
- Single-cell and spatial transcriptomics
- CRISPR and Genetic Engineering
- Gene expression and cancer classification
- Genetics, Bioinformatics, and Biomedical Research
- Parkinson's Disease Mechanisms and Treatments
- interferon and immune responses
- Epilepsy research and treatment
UNSW Sydney
2016-2025
Leipzig University
2017-2023
Bentham Science Publishers (United Arab Emirates)
2013
Bentham Science Publishers (China)
2013
Max Planck Institute for Molecular Genetics
2001-2010
Max Planck Society
2002-2010
Charité - Universitätsmedizin Berlin
2003
German Rheumatism Research Centre
1997-2001
Polish Academy of Sciences
1993-1995
Institute of Human Genetics
1994-1995
Recent studies strongly indicate that aberrations in the control of gene expression might contribute to initiation and progression Alzheimer's disease (AD). In particular, alternative splicing has been suggested play a role spontaneous cases AD. Previous transcriptome profiling AD models patient samples using microarrays delivered conflicting results. This study provides, for first time, transcriptomic analysis distinct regions brain RNA-Seq next-generation sequencing technology. Illumina...
The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor κB (NF-κB)–dependent cytokine expression, is involved in the regulation inflammation-induced immunopathology. We show that twist1 expressed by activated T helper (Th) 1 effector memory (EM) cells. Induction Th cells depended on NF-κB, (NFAT), and interleukin (IL)-12 signaling via signal transducer activator transcription (STAT) 4. Expression was transient after cell receptor engagement, increased...
Over the past decade, focus of molecular biology has shifted from being predominately DNA and protein-centric to having a greater appreciation RNA. It is now accepted that genome pervasively transcribed in tissue- cell-specific manner, produce not only protein-coding RNAs, but also an array noncoding RNAs (ncRNAs). Many these ncRNAs have been found interact with DNA, protein other RNA molecules where they exert regulatory functions. Long (lncRNAs) are subclass particularly interesting due...
RNA-Seq is a recently developed sequencing technology, that through the analysis of cDNA allows for unique insights into transcriptome cell. The data generated by provides information on gene expression, alternative splicing events and presence non-coding RNAs. It has been realised RNAs are more then just artefacts erroneous transcription play vital regulatory roles at genomic, transcriptional translational level. Transcription DNA sense strand produces antisense transcripts. This known as...
Circular RNAs (circRNAs) have been recently identified as a naturally occurring family of widespread and diverse endogenous non-coding that may regulate gene expression in mammals. They are unusually stable RNA molecules with cell type- or developmental stage-specific patterns. However, the role circRNAs pathology complex disease is entirely unknown. Here, we report specific circular transcriptome multiple system atrophy (MSA) brain determined by sequencing. Five circRNAs, namely IQCK,...
Circular RNAs (circRNAs) are a naturally occurring family of non-coding RNA that may regulate gene expression in mammals. circRNAs more stable than messenger due to their resistance exonuclease. A growing body evidence has shown the is regulated during development tissue-specific manner. CircRNAs have been implicated number cancers; however, role endometrial cancer (EC) completely unknown. Here, we report circular transcriptome specific for EC as determined by sequencing. We found overall...
Recent improvements in the accuracy of long-read sequencing (LRS) technologies have expanded scope for novel transcriptional isoform discovery. Additionally, these advancements improved precision transcript quantification, enabling a more accurate reconstruction complex splicing patterns and transcriptomes. Thus, this project aims to take advantage analytical developments discovery analysis RNA isoforms human brain. A set was compiled using three bioinformatic tools, quantifying their...
The human frontal lobe has undergone accelerated evolution, leading to the development of unique features such as language and self-reflection. Cortical grey matter underlying white reflect distinct cellular compositions in lobe. Surprisingly little is known about transcriptomal landscape these regions. Here, for first time, we report a detailed profile (GM) (WM) with resolution alternatively spliced isoforms obtained using RNA-Seq approach. We observed more vigorous transcriptome activity...
Our understanding of mesial temporal lobe epilepsy (MTLE), one the most common form drug-resistant in humans, is derived mainly from clinical, imaging, and physiological data humans animal models. High-throughput gene expression studies human MTLE have potential to uncover molecular changes underlying disease pathogenesis along with novel therapeutic targets. Using RNA- small RNA-sequencing parrallel, we explored differentially expressed genes hippocampus cortex patients who had undergone...
To identify the molecular signaling pathways underlying sudden unexpected death in epilepsy (SUDEP) and high-risk SUDEP compared to control patients with epilepsy.
Abstract Circular RNAs (circRNAs) are a subclass of non-coding which have demonstrated potential as biomarkers for Alzheimer’s disease (AD). In this study, we conducted comprehensive exploration the circRNA transcriptome within AD brain tissues. Specifically, assessed expression patterns in dorsolateral prefrontal cortex collected from nine AD-afflicted individuals and eight healthy controls. Utilising two detection tools, CIRI2 CIRCexplorer2, detected thousands circRNAs performed...
Long intervening non-coding RNAs (lincRNAs) are a recently discovered subclass of RNAs. LincRNAs expressed across the mammalian genome and contribute to pervasive transcription phenomenon. They display tissue-specific species-specific mode expression present abundantly in brain. Here, we report patterns oligodendrocyte maturation-associated long RNA (OLMALINC), which is highly white matter (WM) human frontal cortex compared grey (GM) peripheral tissues. Moreover, identified novel isoform...