A5024756890- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Cancer Risks and Factors
- Cervical Cancer and HPV Research
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Intraperitoneal and Appendiceal Malignancies
- Cardiac, Anesthesia and Surgical Outcomes
- Immunotherapy and Immune Responses
- Reproductive Biology and Fertility
- Genital Health and Disease
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Colorectal and Anal Carcinomas
- Enhanced Recovery After Surgery
- Cancer survivorship and care
- Sarcoma Diagnosis and Treatment
- Anesthesia and Pain Management
- Cancer-related molecular mechanisms research
- vaccines and immunoinformatics approaches
- Cancer Immunotherapy and Biomarkers
Emory University
2022-2024
Community Link
2024
University of Virginia
2014-2023
University of Virginia Health System
2011-2020
Suwon Research Institute
2016-2020
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2016-2020
Gynecologic Oncology Group
2006-2019
University of Alabama at Birmingham
2018
Baylor College of Medicine
2018
Louisiana State University Health Sciences Center New Orleans
2018
To examine implementing an enhanced recovery after surgery (ERAS) protocol for women undergoing major gynecologic at academic institution and compare surgical outcomes before implementation.Two ERAS protocols were developed: a full pathway using regional anesthesia open procedures light without vaginal minimally invasive procedures. Enhanced pathways included extensive preoperative counseling, carbohydrate loading oral fluids surgery, multimodal analgesia with avoidance of intravenous...
Mismatch repair (MMR)-deficient endometrial carcinomas (ECs) bearing Lynch syndrome (LS)-associated germline mutations or sporadic MLH1 promoter hypermethylation (MLH1hm) are highly immunogenic and may represent excellent candidates for therapies targeting the programmed cell death (PD)/programmed ligand-1 (PD-L1) immune checkpoint pathway. This study evaluates PD-L1 expression in MMR-deficient ECs including LS-associated MLH1hm cases, comparison with MMR-intact tumors. Immunohistochemistry...
Women with metabolic disorders, including obesity and diabetes, have an increased risk of developing endometrial cancer. However, the metabolism tumors themselves has been largely understudied. Comparing human cells their nonmalignant counterparts, we found that upregulation glucose transporter GLUT6 was more closely associated cancer phenotype than other hallmark genes, hexokinase 2 pyruvate kinase M2. Importantly, suppression expression inhibited glycolysis survival cells. Glycolysis...
Expanded testing for Lynch syndrome (LS) is increasingly recommended patients with endometrial carcinomas, and immunohistochemistry (IHC) tumor loss of mismatch-repair (MMR) protein expression the most common primary screen. This has led to recognition MMR-IHC-deficient cases without identifiable mutations on directed germline sequencing. The clinical implications such "Lynch-like" (LL) cancers are unclear. We here report clinicopathologic features putative familial carcinoma identified...
Background There are limited treatment options for patients with metastatic or recurrent cervical cancer. Platinum-based chemotherapy plus the anti-vascular endothelial growth factor antibody bevacizumab remains mainstay of advanced treatment. Pembrolizumab is Food and Drug Agency approved programmed death ligand 1 (PD-L1) positive cancer a modest response rate. This first study to report efficacy safety PD-L1 atezolizumab in combination Methods We results from phase II, open-label,...
Abstract Background The role of immune cells in collagen degradation within the tumor microenvironment (TME) is unclear. Immune cells, particularly tumor-infiltrating lymphocytes (TILs), are known to alter extracellular matrix, affecting cancer progression and patient survival. However, quantitative evaluation modulatory impact on architecture TME remains limited. Methods We introduce CollaTIL, a computational pathology method that quantitatively characterizes immune-collagen relationship...
The nearly ubiquitous development of chemoresistant disease remains a major obstacle against improving outcomes for patients with ovarian cancer. In this investigation, we evaluated the preclinical activity MLN4924, an investigational inhibitor NEDD8-activating enzyme, in cancer cells. Efficacy MLN4924 both alone and combination platinum was assessed. Overall, single-agent exhibited moderate cell lines. However, cisplatin or carboplatin produced synergistic effects SKOV3 ES2 cells, as well...
Circular RNAs (circRNAs) are a naturally occurring family of non-coding RNA that may regulate gene expression in mammals. circRNAs more stable than messenger due to their resistance exonuclease. A growing body evidence has shown the is regulated during development tissue-specific manner. CircRNAs have been implicated number cancers; however, role endometrial cancer (EC) completely unknown. Here, we report circular transcriptome specific for EC as determined by sequencing. We found overall...
The Lifestyle Intervention for oVarian cancer Enhanced Survival (LIVES) is a national study of combined diet and physical activity intervention stage II-IV ovarian survival, an under-represented in lifestyle behavioral research. Here, we present the data on recruitment, retention, baseline demographic, clinical behavior characteristics LIVES participants.
In Brief OBJECTIVE To determine clinical characteristics of women with endometriosis-associated intraperitoneal cancers, to assess differences based on the relationship cancer endometriosis, and factors associated survival. METHODS A search medical records at The University Texas M. D. Anderson Cancer Center from 1970 1999 identified patients who had synchronous endometriosis cancer. Demographic clinicopathologic were evaluated for correlation RESULTS One hundred fifteen identified: 25...
The objective of this study was to evaluate the treatment outcomes and risk factors women with surgical stage I endometrial adenocarcinoma who were initially treated surgery alone subsequently developed isolated vaginal recurrences. Patients diagnosed from 1975 2002 identified tumor registry databases at seven institutions. All patients including a total hysterectomy, bilateral salpingo-oophorectomy, pelvic (+/- para-aortic) lymph node dissection, peritoneal cytology did not receive...