A5000148810- Endometrial and Cervical Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Uterine Myomas and Treatments
- Ovarian cancer diagnosis and treatment
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Metabolomics and Mass Spectrometry Studies
- Airway Management and Intubation Techniques
- Cardiac Ischemia and Reperfusion
- Genetic Neurodegenerative Diseases
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Peroxisome Proliferator-Activated Receptors
- Neonatal Respiratory Health Research
- Immunodeficiency and Autoimmune Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Mitochondrial Function and Pathology
- Gynecological conditions and treatments
- Neurological diseases and metabolism
- Chronic Myeloid Leukemia Treatments
- Pharmacology and Obesity Treatment
- Hormonal Regulation and Hypertension
- Hereditary Neurological Disorders
- Reproductive Biology and Fertility
University of Virginia
2014-2024
Novant Health
2018
Oncology Specialists
2018
University of Virginia Medical Center
2015-2016
University of South Carolina
2016
Sydney Children's Hospital
1990
Prince of Wales Hospital
1972-1982
UNSW Sydney
1973-1976
Royal Prince Alfred Hospital
1972
The University of Sydney
1972
Women with metabolic disorders, including obesity and diabetes, have an increased risk of developing endometrial cancer. However, the metabolism tumors themselves has been largely understudied. Comparing human cells their nonmalignant counterparts, we found that upregulation glucose transporter GLUT6 was more closely associated cancer phenotype than other hallmark genes, hexokinase 2 pyruvate kinase M2. Importantly, suppression expression inhibited glycolysis survival cells. Glycolysis...
In infants and piglets subjected to periods of circulatory arrest at 20 degrees C there was close correlation between duration delay in return electroencephalographic activity. Post mortem studies demonstrated histological evidence brain damage patients after C. Similar changes were piglets, including some who had complete E.E.G. clinical recovery from arrest.
The study objectives were to describe outcomes of obese patients with early endometrial cancer following primary non-surgical treatment, assess predictors response, and estimate the increased surgical risk for these women.Retrospective chart review identified women stage at a single institution BMI ≥ 30 kg/m2 who did not undergo surgery as treatment modality due obesity medical co-morbidities. Clinicopathologic factors abstracted, characteristics responders vs. non-responders compared...
We report diagnosis and management of stage IV papillary serous uterine cancer with initial clinical presentation as a skin rash.A 62-year-old postmenopausal female developed an erythematous rash beginning on her right lower abdomen progressively spreading to left abdomen, vulva, neck. After trial antibiotic treatment, biopsy neck thigh nodules revealed carcinoma. Abdominopelvic tomography endometrial thickening 5 cm adnexal mass. Subsequent also carcinoma, pathology similar that the...
PURPOSE: Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in gynecologic oncology surgical patients. Many centers use neuraxial analgesia (NA), which affects the timing prophylactic anticoagulation. In 2012, we determined that rate VTE patients undergoing laparotomy with NA was higher than those who received alternative pain control. addition, compliance preoperative anticoagulation guidelines only 40%. We undertook quality initiative (QI) project to increase 80%...
Permanent sequelae of nasotracheal intubation are uncommon, but acute ulceration and squamous metaplasia occur. Histological sections from the trachea main bronchi were examined in 12 infants. A tube had been inserted during first two weeks life these infants place for more than one week. In four cases patient died some time (7 to 108 days) after extubation. Similar patients who not intubated, intubated only attempted resuscitation, or several hours studied comparison. The classified...
KARENYI<sup>1</sup>(1961) described two types of adrenal hypoplasia in infancy. He called one the anencephalic or secondary type because morphological similarity to hypoplastic adrenals seen with anencephaly, a "miniature adult" adrenal. other primary cytomegalic presence large cortical cells abnormal nuclear and cytoplasmic staining. found literature papers describing five deaths from hypofunction which histology was described.<sup>2-6</sup>All these infants develop symptoms before age 1...
The nail patella syndrome–A report of a family. B. A. Pussell, J. Charlesworth, G. Macdonald and W. de C. Baker, Aust. N.Z. Med., 1977, 7, pp. 20–23. This describes two cases the Nail Patella Syndrome with renal involvement. Pathological studies include immunochemistry, light microscopy, immunofluorescence electron microscopy. possibility secondary immune damage to altered glomerular basement membrane is suggested as cause progressive disease which occurs in some these cases.
Objectives Large granular lymphocyte (LGL) leukemia is a rare hematologic malignancy characterized by clonal expansion of cytotoxic T-cells frequent somatic activating STAT3 mutations. Based on the disease overlap between LGL rheumatoid arthritis (RA)a putative role for CD8+ in RA we hypothesized that mutations may be detected patient correlate with clinical characteristics. Methods Blood samples, parameters, and demographics were collected from 98 patients 9 healthy controls (HCs). cell DNA...
SUMMARY Three cases with sensory peripheral neuropathies are reported. Case 1 presented scoliosis and 2 3 abnormal gait. None had trophic limb changes, evidence of weakness or a tendency to self‐mutilation each normal motor studies on neurophysiological testing.' Sural nerve biopsies showed severe loss myelinated fibres case denervation muscle biopsy. These as examples hereditary neuropathy type II. They unusual in that they do not have changes. RÉSUMÉ neuropathie sensorielle héréditaire de...
Ten of fifteen infants and children with Wilms' tumour who were treated between 1964 1971 are alive 9 have no evidence disease. The last 5 patients pulmonary metastases been definitively Injections vincristine weekly radiotherapy to the lung fields 4 showed complete regression which has continued for at least 20 months, while is continuing in fifth child. combination nephrectomy, bed actinomycin D therapy follow-up courses advocated localized important role combined radiation metastatic...
The early diagnosis, appropriate management, and pharmacological treatment of hypertension in those with diabetes mellitus are key preventing reducing the significant risk cardiovascular disease-related morbidity mortality this patient population. Despite universal recognition importance management mellitus, there still remains controversy on blood pressure at which to initiate pharmacologic therapy and, once initiated, what goal achieve. This paper will review current recommendations...
<p>Supplemental Methods. Includes more detailed methods for the main manuscript and additional supplemental including Cell Culture, Sources of drugs/radioactive tracers,Targets/functions metabolic drugs antioxidants, Preparation protein lysates, Nutrient metabolism assays, qPCR primer sequences, Cytotoxicity doubling times, Cellular ATP levels, ROS Mass spectrometry Acetyl-CoA Pyruvylated-CoA, Supplemental References.</p>