A5082377409- BRCA gene mutations in cancer
- Ovarian cancer diagnosis and treatment
- Palliative Care and End-of-Life Issues
- Chronic Lymphocytic Leukemia Research
- Genetic factors in colorectal cancer
- Biochemical effects in animals
- Endometrial and Cervical Cancer Treatments
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Colorectal Cancer Treatments and Studies
- Neuroscience and Neuropharmacology Research
- Advanced Breast Cancer Therapies
- Dermatology and Skin Diseases
- Uterine Myomas and Treatments
- Lung Cancer Treatments and Mutations
- Neuroscience of respiration and sleep
- Cardiac Arrest and Resuscitation
- Migration, Health and Trauma
- Skin Protection and Aging
- Opioid Use Disorder Treatment
- PI3K/AKT/mTOR signaling in cancer
- Frailty in Older Adults
- Cancer Risks and Factors
- Neutropenia and Cancer Infections
- Cancer Immunotherapy and Biomarkers
Rhode Island Department of Health
2025
Brown University
2025
Innovation Plasturgie Composites
2023-2024
Weill Cornell Medicine
2021-2024
Kaiser Permanente
2020-2024
Presbyterian Hospital
2021-2024
New York Hospital Queens
2022-2024
NewYork–Presbyterian Hospital
2022-2024
Cornell University
2021-2024
Kaiser Permanente San Francisco Medical Center
2014-2023
Venetoclax is a BCL2 inhibitor approved for 17p-deleted relapsed/refractory chronic lymphocytic leukemia with activity following kinase inhibitors. We conducted multicenter retrospective cohort analysis of patients treated venetoclax to describe outcomes, toxicities, and treatment selection discontinuation. A total 141 were included (98% relapsed/refractory). Median age at initiation was 67 years (range 37-91), median prior therapies 3 (0-11), 81% unmutated IGHV, 45% del(17p), 26.8% complex...
Margo Wilson and Martin Daly began scientific work to explain intimate partner homicides (IPHs). Key their was women’s increased risk of IPH victimization relative men. In the 1990s, many U.S. jurisdictions implemented Domestic Violence Fatality Review Committees (DVFRCs) improve responses potentially lethal abuse. We report findings from 117 closed heterosexual cases collected by Denver Metro DVFRC 1991-2009. As expected, IPHs perpetrated women against men are frequently motivated...
<h3>Background</h3> PD-1 and CTLA-4 inhibitors are associated with several adverse events including a spectrum of immune-related effects (irAEs). Neurologic irAEs uncommon occurrences varied presentations. We describe two separate cases ipilimumab meningoencephalomyelitis demyelinating polyneuropathy unusual <h3>Case presentation</h3> Two melanoma patients were treated in the adjuvant setting. The first patient developed meningoencephalitis following 3 doses ipilimumab. MRI imaging brain...
To estimate whether performance of salpingectomy compared with standard tubal ligation for sterilization at the time cesarean delivery increases operating or complication rates.A randomized controlled noninferiority trial was performed a single academic institution. Women undergoing planned who desired were to ligation. The primary outcome length procedure, margin set 5 minutes. With one-sided independent sample t test, achieve power 90% an α 0.05, 18 women needed complete each...
The comparative efficacy and safety of lorlatinib, a third-generation anaplastic lymphoma kinase (ALK) tyrosine inhibitor (TKI), versus second-generation ALK TKIs as first-line treatment for ALK+ advanced/metastatic nonsmall cell lung cancer (NSCLC) remains uncertain there are no head-to-head clinical trials. Matching-adjusted indirect comparisons (MAICs) were conducted using phase III trial data demonstrating superior over crizotinib, first-generation TKI. MAICs to compare lorlatinib...
Myxomas are the most common primary cardiac tumors, frequently found in left atrium. We present a case of an atrial myxoma. An in-depth review myxoma is presented, examining important clinical symptoms and diagnostic indicators. The treatment then discussed, with emphasis on current therapies. extensive literature has been performed to comprehensive causes, pathophysiology
Abstract BACKGROUND Colorectal cancer (CRC) is the third most common cause of deaths; however, rates regular screening for this are low. A quality improvement (QI) program to increase CRC was developed use in a managed care health plan. METHODS Thirty‐six provider organizations (POs) contracting with plan were recruited randomized controlled effectiveness trial testing QI program. The intervention delivered over 2‐year period, and its assessed by chart review random sample patients from each...
This article summarizes our approach to the diagnosis of immune thrombocytopenia (ITP), its secondary forms, and choice second-line treatment options. We very briefly summarize first-line then utilize a case-based approach. first explore persistent, chronic ITP in younger female. consider many possibilities beyond primary e.g., hypogammaglobulinemia, infection, anemia, how their management. The journey continues throughout pregnancy post-partum period eventually includes fourth-line after...
Acute myeloid leukemias (AMLs) with monocytic differentiation or without recurring cytogenetic abnormalities have prognostic significance. Therefore, it is important to recognize such cases. Monocytic identified by morphology and confirmed cytochemical stains flow cytometry. However, the materials for analyses are not always available (air-dried aspirate smears, touch preparations, fresh cells). Thus, utility of CD163, a hemoglobin scavenger molecule present on monocytes/macrophages, in...
Abstract Objective To explore health care workers identified barriers to cervical cancer screening in rural Southwest Virginia. Design and Sample A descriptive study utilizing telephone‐based structured interviews conventional content analysis. All free federally funded clinics within a 75 mile radius of Virginia's Districts 1, 2, 3 were contacted for participation the study. Measures Organizational information such as composition clinical staff, services provided, cost services, recorded...
Morbidity and mortality conferences are Accreditation Council for Graduate Medical Education-required educational series that part of all residency training programs. This conference offers trainees an opportunity to discuss patient cases where errors or complications may have occurred. Conventionally, most the allotted time is spent on case presentation therapeutic debates, which a lost teach fundamental principles safety, error analysis, strategies system-wide improvement. The goal this...