A5036606309- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
- Pelvic floor disorders treatments
- Cystic Fibrosis Research Advances
- Anorectal Disease Treatments and Outcomes
- Adenosine and Purinergic Signaling
- Systemic Sclerosis and Related Diseases
- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- Estrogen and related hormone effects
- Wildlife Ecology and Conservation
- Neurogenesis and neuroplasticity mechanisms
- Asthma and respiratory diseases
- Chronic Lymphocytic Leukemia Research
- Alzheimer's disease research and treatments
- Immune Cell Function and Interaction
- Trauma and Emergency Care Studies
- Axon Guidance and Neuronal Signaling
- Healthcare Operations and Scheduling Optimization
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Pediatric health and respiratory diseases
- Toxoplasma gondii Research Studies
University of Virginia
2019-2025
University of Virginia Health System
2023
Charlottesville Medical Research
2022
National Zoological Park
2018-2021
Library of Virginia
2019-2021
George Mason University
2018-2021
Smithsonian Conservation Biology Institute
2018-2021
Cystic fibrosis (CF) is associated with worsening of depression and anxiety symptoms. Elexacaftor/tezacaftor/ivacaftor (Trikafta®), a cystic transmembrane regulator (CFTR) modulator approved in 2019, significantly improves lung function, decreases pulmonary exacerbations, quality life. Studies are needed to evaluate the effects Trikafta on symptoms depression.Do adults CF report change after initiation?A retrospective chart review was conducted patients (n = 127) receiving care from January...
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) plays a key role progression and response to therapy. dense PDAC stroma causes hypovascularity, which leads hypoxia. Here, we showed that hypoxia drives long-lasting epithelial-mesenchymal transition (EMT) primarily through positive-feedback histone methylation-MAPK signaling axis. Transformed cells preferentially underwent EMT hypoxic regions multiple model systems. Hypoxia drove cell autonomous cells, which, unlike...
Background: This pragmatic randomized controlled trial aimed to assess the effect of a passive display artificial intelligence (AI)-based predictive analytics on hours free clinical deterioration events among medical and surgical patients in an acute care cardiology medical-surgical ward. Methods: 10,422 inpatient visits were randomly assigned by cluster intervention group risk trajectories or control usual care. The was undertaken 85-bed cardiac surgery ward academic hospital with...
Abstract Background The Cystic Fibrosis Foundation Patient Registry (CFFPR) reports a high prevalence of asthma (34.6%) in people with (PwCF). While our current understanding this relationship is limited, type 2 inflammatory (T2) phenotype has often been identified CF patients. Research question This study aimed to evaluate the between eosinophilic T2 and CF-related pulmonary outcomes microbiological data. Study design methods We conducted retrospective chart review adult patients (18 older;...
Objective The 2019 novel coronavirus [COVID-19] pandemic has necessitated the implementation of public health initiatives [PHI] to slow viral spread. We evaluated effectiveness PHI through a survey COVID-19 knowledge, attitudes and practices [KAP]. Methods This cross-sectional study was conducted primarily during stay-at-home orders in New York San Francisco. A volunteer sample 675 U.S. participants completed KAP questionnaire after electronic distribution. Results Participants had good...
<div>Abstract<p>The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) plays a key role progression and response to therapy. The dense PDAC stroma causes hypovascularity, which leads hypoxia. Here, we showed that hypoxia drives long-lasting epithelial–mesenchymal transition (EMT) primarily through positive-feedback histone methylation–MAPK signaling axis. Transformed cells preferentially underwent EMT hypoxic regions multiple model systems. Hypoxia drove cell...
Abstract Large granular lymphocyte (LGL) leukemia is a rare hematological disorder with expansion of the T‐cell or natural killer (NK) cell lineage. Signal transducer and activator transcription 3 (STAT3) exhibits somatic activating mutations in 30%‐40% LGL cases. Transcriptional targets STAT3 include inflammatory cytokines, thus previous studies have measured cytokine levels patients compared to normal donors. Sphingolipid metabolism growing area cancer research, efforts focused on drug...
The bacterial pathogen Shigella flexneri causes 270 million cases of bacillary dysentery worldwide every year, resulting in more than 200,000 deaths. S . pathogenic properties rely on its ability to invade epithelial cells and spread from cell within the colonic epithelium. This dissemination process relies actin-based motility cytosol infected formation membrane protrusions that project into adjacent resolve double-membrane vacuoles (DMVs) which escapes, thereby achieving cell-to-cell...
Introduction Urinary incontinence (UI) is highly prevalent in low- and middle-income countries (LMIC). Concurrently, the availability of surgical or conservative UI treatments LMIC limited. Methods We conducted a prospective feasibility study Belize women with treated pelvic floor physical therapy (PFPT) education (PFE). Patients received individual PFPT/PFE over 2 days, consisting biofeedback-enhanced PFMT addition to behavioral, dietary, general education. Patient completed daily 6-month...
The prefrontal cortex controls food reward seeking and ingestion, playing important roles in directing attention, regulating motivation towards pursuit, the assignment of salience value. cell types that mediate these behavioral functions, however, are not well described. We report here optogenetic activation vasoactive peptide expressing (VIP) interneurons both infralimbic (IL) prelimbic (PL) divisions medial mice is sufficient to reduce acute, binge-like intake high calorie palatable...
Background: In Alzheimer’s disease (AD) brain, neuronal polarity and synaptic connectivity are compromised. A key structure for regulating functions of neurons is the axon initial segment (AIS), which segregates somatodendritic from axonal proteins initiates action potentials. Toxic tau species, including extracellular oligomers (xcTauOs), spread pathology neuron to by a prion-like process, but few other cell biological effects xcTauOs have been described. Objective: Test hypothesis that AIS...
. Very few predictive models have been externally validated in a prospective cohort following the implementation of an artificial intelligence analytic system. This type real-world validation is critically important due to risk data drift, or changes definitions clinical practices over time, that could impact model performance contemporaneous cohorts. In this work, we report analytics tool developed before COVID-19 and demonstrate during pandemic.
Health evaluations were conducted on individuals (n = 62, age < 1 to 11 yr) from a captive red panda (Ailurus fulgens styani) population at the Chengdu Research Base for Giant Panda Breeding in Sichuan Province, People's Republic of China. Individuals anesthetized using combinations ketamine, dexmedetomidine, diazepam, isoflurane, and tiletamine/zolazepam. Whereas physical exams revealed no abnormalities 40% pandas, 24% had dental 18% orthopedic abnormalities. As is only member family...
The maned wolf ( Chrysocyon brachyurus ) is an induced ovulator. Though the mechanism of ovulation induction remains unknown, it suspected to be urinary chemical signals excreted by males. This study assessed volatile organic compounds (VOCs) in weekly urine samples across 5 months from 13 wolves (6 intact males, 1 neutered male, 6 females) with goal identifying VOCs that are differentially expressed sex, reproductive status, and pairing status. Solid-phase microextraction (SPME) gas...
Background: Raynaud phenomenon, with and without scleroderma, is a common vasospastic condition that manifests extremity pain skin discoloration. When conservative management fails, complications such as ischemia, ulceration, gangrene may warrant surgical intervention. The purpose of this study was to determine the risk factors use intervention in population. Methods: A national insurance claims–based database patient records from Centers for Medicare Medicaid Services used data collection....
Background: Review platforms such as Yelp © are increasingly utilized by patients establishing care and may contain substantial information regarding patient preferences potential biases. Our aims were to (1) analyze satisfaction through identifying factors associated with positive negative reviews for plastic surgery providers across the United States, (2) investigate association between overall rating different physician practice based on gender race. Methods: Reviews of Plastic Surgery...
A life-threatening manifestation of Covid-19 infection is a cytokine storm that requires hospitalization and supplemental oxygen. Various strategies to reduce inflammatory cytokines have had some success in limiting improving survival. Agonists adenosine A2A receptors (A2AR) release from most immune cells. Apadenoson potent selective anti-inflammatory analog reduces inflammation. When administered by subcutaneous osmotic pumps mice infected with SARS CoV-2, was found improve the outcomes as...