A5101407472- Ecology and Conservation Studies
- Agriculture, Soil, Plant Science
- Ubiquitin and proteasome pathways
- Innovation in Digital Healthcare Systems
- Bioinformatics and Genomic Networks
- Groundwater and Isotope Geochemistry
- DNA Repair Mechanisms
- Muscle metabolism and nutrition
- Service-Oriented Architecture and Web Services
- Distributed and Parallel Computing Systems
- Multimedia Communication and Technology
- Energy and Environmental Systems
- Computational Drug Discovery Methods
- Advanced Data Storage Technologies
- Diverse Approaches in Healthcare and Education Studies
- Education and Learning Interventions
- Muscle Physiology and Disorders
- RNA modifications and cancer
- Groundwater flow and contamination studies
- Cancer therapeutics and mechanisms
- Cellular Automata and Applications
- Advanced biosensing and bioanalysis techniques
- Internet of Things and Social Network Interactions
- Bioactive Compounds and Antitumor Agents
- Educational Systems and Policies
Yonsei University
2020-2025
Pohang University of Science and Technology
2002-2023
Samsung (South Korea)
2016-2023
Pusan National University
2023
University Health System
2022-2023
Hokkaido University
2019-2021
Ministry of Agriculture, Food and Rural Affairs
2019
Seoul National University
2018
Michigan State University
2017
LG (South Korea)
2014-2016
Human peroxiredoxins 1 and 2, also known as Prx1 Prx2, are more than 90% homologous in their amino acid sequences. Prx2 elevated various cancers shown to influence diverse cellular processes. Although growth regulatory role has traditionally been attributed the peroxidase activity, physiological significance of this function is unclear because proteins highly susceptible inactivation by H(2)O(2). A chaperone activity appears emerge when lost. Structural studies suggest that they may form a...
The minichromosome maintenance protein homologs MCM8 and MCM9 have previously been implicated in DNA replication elongation prereplication complex (pre-RC) formation, respectively. We found that physically associate with each other is required for the stability of mammalian cells. Depletion or human cancer cells loss function mutation mouse embryo fibroblasts sensitizes to interstrand cross-linking (ICL) agent cisplatin. Consistent a role repair ICLs by homologous recombination (HR),...
Tamoxifen resistance is often observed in the majority of estrogen receptor-positive breast cancers and it remains as a serious clinical problem cancer management. Increased aerobic glycolysis has been proposed one mechanisms for acquired to chemotherapeutic agents cells such adriamycin. Herein, we report that rates LCC2 LCC9--tamoxifen-resistant human cell lines derived from MCF7--are higher than those MCF7S, which parent MCF7 subline. Inhibition key glycolytic enzyme hexokinase-2 resulted...
MCM8-9 complex is required for homologous recombination (HR)-mediated repair of double-strand breaks (DSBs). Here we report that DNA resection by MRN (MRE11-RAD50-NBS1) at DSBs to generate ssDNA. interacts with and the nuclease activity stable association DSBs. The ATPase motifs are recruitment MRE11 foci damage. Homozygous deletion MCM9 found in various cancers sensitizes a cancer cell line interstrand-crosslinking (ICL) agents. A cancer-derived point mutation or an SNP on MCM8 associated...
A 64-word-line-stacked 512-Gb 3-b/cell 3-D NAND flash memory is presented. After briefly examining the challenges that occur to a stack, several technologies are suggested resolve issues. For performance enhancement, novel program method hiding two-page data loading time This paper also discusses an electrical annealing improving reliability characteristic by removing holes in shallow traps. In addition, valley tracking read for reducing timing overhead at retry introduced fast finding...
Since the first demonstration of a production quality three-dimensional (3D) stacked-word-line NAND Flash memory [1], 3b/cell 3D has seen areal density increases more than 50% per year due to aggressive development 3D-wordline-stacking technology. This trend been consistent for last three consecutive years [2-4], however storage market still requires higher diverse digital applications. A 4b/cell technology is one promising solution increase bit [5]. In this paper, we propose with 12MB/s...
Numerical integration methods based on the Lie group theoretic geometrical approach are applied to articulated multibody systems with rigid body displacements, belonging special Euclidean SE(3), as a part of generalized coordinates. Three integrators, Crouch-Grossman method, commutator-free and Munthe-Kaas formulated for equations motion systems. The proposed provide singularity-free integration, unlike Euler-angle while approximated solutions always evolve underlying manifold structure,...
Long noncoding RNAs (lncRNAs) have emerged as a major regulator of cell physiology, but many which no known function. CDKN1A/p21 is an important inhibitor the cell-cycle, DNA damage response and effector tumor suppressor p53, playing crucial role in development prevention. In order to identify for progression, we performed siRNA screen human lncRNAs required proliferation, identified novel lncRNA, APTR, that acts trans repress promoter independent p53 promote proliferation. APTR associates...
Drug repositioning aims to identify new therapeutic indications for approved medications. Recently, the importance of computational drug has been highlighted because it can reduce costs, development time, and risks compared traditional discovery. Most approaches in this area use networks systematic analysis. Inferring drug-disease associations is then defined as a link prediction problem heterogeneous network composed drugs diseases. In article, we present novel method repositioning, named...
The nearly ubiquitous development of chemoresistant disease remains a major obstacle against improving outcomes for patients with ovarian cancer. In this investigation, we evaluated the preclinical activity MLN4924, an investigational inhibitor NEDD8-activating enzyme, in cancer cells. Efficacy MLN4924 both alone and combination platinum was assessed. Overall, single-agent exhibited moderate cell lines. However, cisplatin or carboplatin produced synergistic effects SKOV3 ES2 cells, as well...
The treatment of activated B cell-like DLBCL (ABC-DLBCL) is one the urgent unmet medical needs because it most resistant subtype to current therapies eagerly awaiting effective therapeutic strategies. Recently, paracaspase MALT1 has emerged as a promising target for ABC-DLBCL. Herein, we report new class inhibitors developed by high-throughput screening and structure-based drug design. original hit, 4-amino-1,2-naphthoquinone series inhibited activity but suffered from poor cellular...
Genome-wide association studies (GWAS) can be used to infer genome intervals that are involved in genetic diseases. However, investigating a large number of putative mutations for GWAS is resource- and time-intensive. Network-based computational approaches being efficient disease-gene prediction. methods based on the underlying assumption genes causing same diseases located close each other molecular network, such as protein-protein interaction (PPI) network. In this survey, we provide an...
Apigenin, one of the most common flavonoids, has been shown to possess anti-inflammatory, anticarcinogenic, and free radical-scavenging properties. However, influence apigenin on immunostimulatory effects maturation dendritic cells (DC) remains, for part, unknown. In this study, we have attempted ascertain whether influences expression surface molecules, dextran uptake, cytokine production, T-cell differentiation as well signaling pathways underlying these phenomena in murine bone...
(1) The purpose of this study was to investigate the effect whey protein supplementation under dietary control on improvements in muscle mass and function following resistance exercise training. (2) Thirty-two men were randomly assigned a group taking isolate (PSG, n = 17) placebo (CON, 15). Participants provided with three meals per day corresponding estimated individual daily energy intake. supervised program conducted 60 min day, six days week, for four weeks. (3) Post-intervention, there...
NAND flash memory is widely used as a cost-effective storage with high performance [1–2]. This paper presents 128Gb multi-level cell (MLC) 150 cells/string structure in 14nm CMOS that can be device. also introduces several approaches to compensate for reliability and degradations caused by the transistors structure. A technique was developed suppress background pattern dependency (BPD) applying low voltage upper word lines (WLs) - drain side(SSL side) WLs respect location of selected WL...
State estimation problem with time delayed measurements is addressed. In dynamic system noise, after taking measurements, it often requires some until that available in a filter. A filter not considering this delay cannot be used since current measurement related past state. These solved augmented state Kalman filter, and uncertainty of the also resolved based on probability distribution delay. The proposed method analyzed by simple example, its consistency verified.
Many agents used for chemotherapy, such as doxorubicin, interfere with DNA replication, but the effect of this interference on transcription is largely unknown. Here we show that doxorubicin induces firing dense clusters neoreplication origins lead to stalled replication forks in gene-rich parts genome, particularly expressed genes. Genes overlap these are actively dechromatinized, unwound, and repressed by an ATR-dependent checkpoint pathway. The ATR pathway causes a histone chaperone...