A5100331466- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- MRI in cancer diagnosis
- Organ Transplantation Techniques and Outcomes
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Viral-associated cancers and disorders
- Hepatitis B Virus Studies
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Genetic and Kidney Cyst Diseases
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Force Microscopy Techniques and Applications
- Pediatric Hepatobiliary Diseases and Treatments
- Garlic and Onion Studies
- Advanced Electron Microscopy Techniques and Applications
The University of Texas MD Anderson Cancer Center
2020-2025
Yonsei University
2011-2025
Severance Hospital
2018-2025
Chungnam National University
2016-2024
Korea Research Institute of Bioscience and Biotechnology
2024
Korea University
2024
Hanyang University
2024
Korea Research Institute of Standards and Science
2024
Research Institute of Radio
2023
SK Group (South Korea)
2023
Vascular endothelial growth factor (VEGF) is a critical mediator of blood vessel formation during development and in pathological conditions. In this study, we demonstrate that VEGF bioavailability regulated extracellularly by matrix metalloproteinases (MMPs) through intramolecular processing. Specifically, show subset MMPs can cleave matrix-bound isoforms VEGF, releasing soluble fragments. We have mapped the region MMP processing, generated recombinant forms mimic MMP-cleaved MMP-resistant...
Objective: We compared surgical resection (SR) and radiofrequency ablation (RFA) as first-line treatment in patients with hepatocellular carcinoma (HCC) based on the risk of microvascular invasion (MVI). Background: The best curative modality between SR RFA HCC MVI remains unclear. Methods: Data from 2 academic cancer center-based cohorts a single, small (≤3 cm) who underwent were used to derive (n = 276) validate 101) prediction models for using clinical imaging variables. model was...
A crucial step in human breast cancer progression is the acquisition of invasiveness. There a distinct lack cell culture models to study transition from preinvasive invasive phenotype as it may occur "spontaneously" vivo. To delineate molecular alterations important for this transition, we isolated epithelial lines that showed partial loss tissue polarity three-dimensional reconstituted basement membrane cultures. These cells remained noninvasive; however, unlike their nonmalignant...
ABSTRACT Autocrine VEGF is necessary for endothelial survival, although the cellular mechanisms supporting this function are unknown. Here, we show that – even after full differentiation and maturation continuous expression of by cells needed to sustain vascular integrity viability. Depletion from endothelium results in mitochondria fragmentation suppression glucose metabolism, leading increased autophagy contributes cell death. Gene-expression profiling showed regulation cycle mitochondrial...
Breast cancers commonly become resistant to EGFR-tyrosine kinase inhibitors (EGFR-TKIs); however, the mechanisms of this resistance remain largely unknown. We hypothesized that may originate, at least in part, from molecular alterations activate signaling downstream EGFR. Using a screen measure reversion malignant cells into phenotypically nonmalignant 3D gels, we identified FAM83A as candidate cancer-associated gene capable conferring EGFR-TKIs. overexpression cancer increased proliferation...
Tamoxifen resistance is often observed in the majority of estrogen receptor-positive breast cancers and it remains as a serious clinical problem cancer management. Increased aerobic glycolysis has been proposed one mechanisms for acquired to chemotherapeutic agents cells such adriamycin. Herein, we report that rates LCC2 LCC9--tamoxifen-resistant human cell lines derived from MCF7--are higher than those MCF7S, which parent MCF7 subline. Inhibition key glycolytic enzyme hexokinase-2 resulted...
Abstract Background Previous studies report increasing cholangiocarcinoma (CCA) incidence up to 2015. This contemporary retrospective analysis of CCA and mortality in the US from 2001-2017 assessed whether continued increase beyond Patients Methods (≥18 years) with were identified National Cancer Institute Surveillance, Epidemiology, End Results 18 cancer registry (International Classification Disease for Oncology [ICD-O]-3 codes: intrahepatic [iCCA], C221; extrahepatic [eCCA], C240, C241,...
GPR4 is a G protein-coupled receptor expressed in the vasculature, lung, kidney, and other tissues.In vitro ectopic overexpression studies implicated sensing extracellular pH changes leading to cyclic AMP (cAMP) production.To investigate its biological roles vivo, we generated GPR4-deficient mice by homologous recombination.Whereas GPR4-null adult appeared phenotypically normal, neonates showed higher frequency of perinatal mortality.The average litter size from ؊/؊ intercrosses was ϳ30%...
The binding kinetics between cell surface receptors and extracellular biomolecules is critical to all intracellular intercellular activity. Modeling prediction of receptor-mediated functions are facilitated by measurement the properties on whole cells, ideally indicating subcellular locations or cytoskeletal associations that may affect function bound receptors. This dual need particularly acute vis à ligand engineering clinical applications antibodies neutralize pathological processes....
Colitis is a frequent, clinically-significant immune-related adverse event caused by anti-programmed death-1 (PD-1). The clinical features, timing, and management of colitis with anti-PD-1-based regimens are not well-characterized. Patients advanced melanoma that received either anti-PD-1 monotherapy ("monotherapy") or combined ipilimumab ("combination therapy") were screened from 8 academic medical centers, to identify those clinically-relevant (colitis requiring systemic steroids). Of 1261...
The topical application of minoxidil may achieve millimolar concentrations in the skin. We investigated whether could induce vascular endothelial growth factor (VEGF), a possible effector for minoxidil-mediated hair growth, and how it occurred at molecular level. Cell-based experiments were performed to investigate mechanism underlying induction VEGF. inhibitory effect on hypoxia-inducible (HIF) prolyl hydroxylase-2 (PHD-2) was tested by an vitro von Hippel–Lindau protein (VHL) binding...