A5008950088- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Food Quality and Safety Studies
- Mental Health Research Topics
- Biotin and Related Studies
- Phytochemicals and Antioxidant Activities
- Hedgehog Signaling Pathway Studies
- Kruppel-like factors research
- Geographic Information Systems Studies
- Metabolism, Diabetes, and Cancer
- Advanced Glycation End Products research
- Phytochemistry and Biological Activities
- Phytochemical and Pharmacological Studies
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Diet, Metabolism, and Disease
- Hibiscus Plant Research Studies
- Diabetes Management and Research
- Genetic Syndromes and Imprinting
- Biochemical effects in animals
Korea University
2024
Kangwon National University
2023
Sookmyung Women's University
2013-2018
Universitätskinderklinik
1984
Tamoxifen resistance is often observed in the majority of estrogen receptor-positive breast cancers and it remains as a serious clinical problem cancer management. Increased aerobic glycolysis has been proposed one mechanisms for acquired to chemotherapeutic agents cells such adriamycin. Herein, we report that rates LCC2 LCC9--tamoxifen-resistant human cell lines derived from MCF7--are higher than those MCF7S, which parent MCF7 subline. Inhibition key glycolytic enzyme hexokinase-2 resulted...
Abstract Autosomal polycystic kidney disease (ADPKD) is a common inherited renal characterized by the development of numerous fluid-filled cysts in both kidneys. We investigated miRNA-mediated regulatory systems and networks that play an important role during cystogenesis through integrative analysis miRNA- RNA-seq using two ADPKD mouse models (conditional Pkd1- or Pkd2 -deficient mice), at three different time points (P1, P3, P7). At each point, we identified 13 differentially expressed...
Altered miRNA (miR) expression occurs in various diseases. However, the therapeutic effect of miRNAs autosomal dominant polycystic kidney disease (ADPKD) is unclear. Genome-wide analyses and DNA methylation status were conducted to identify crucial end-stage ADPKD. miR-192 -194 levels down-regulated with hypermethylation at these loci, mainly intermediate late stages, not early stage, cystogenesis, suggesting their potential impact on cyst expansion. Cyst expansion has been strongly...
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common inherited disorders. ADPKD caused by mutations in gene encoding either 1 (PKD1) or 2 (PKD2). Patients with show progressive growth cystic fluid-filled renal cysts. Here, we used Pkd2f/fcontrol mice and Pkd2f/f :HoxB7-Cre experimental mice, which are bred to have a conditional deletion Pkd2 collecting ducts, analyzed expression pattern microRNAs (miRNAs) tissues from Pkd2f/f:HoxB7-Cre mice. Decreased miR-20b-5p...
Although autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease, and characterized by the formation of multiple fluid-filled cysts, which results in renal failure, early diagnosis treatment ADPKD have yet to be defined. Herein, we observed that promoter region gene encoding mucin-like protocadherin (MUPCDH) was hypermethylated tissue patients with compared non-ADPKD controls. Inversely, MUPCDH significantly repressed ADPKD, especially cyst-lining cells. Our indicate...
Seasoning is an ingredient used to enhance the taste of food, and it one most commonly ingredients in cooking.On other hand, there has been limited research on contents pantothenic acid pyridoxine seasonings.Therefore, this study measured 56 types seasonings using HPLC/DAD HPLC/FLD methods.The were 0.0000∼15.326mg/100 g 0.0000∼0.385mg/100 g, respectively.For spices, 0.000∼15.326mg/100 0.000∼0.385mg/100 respectively.Fermented soybean products contained 0.000∼11.497mg/100 0.000∼0.173mg/100...
본 연구는 발효 무궁화 추출물과 비발효 추출물로 나누어 발효하였을 때, 추출물의 항산화 활성과 혈액순환 개선에 미치는 효과가 추출물보다 더 높은지 조사하려고 진행되었다. In vitro 실험에서 활성을 분석하기 위해서 항산화의 생리활성 물질인 polyphenol과 flavonoid의 함량을 비롯한 DPPH radical 소거효능을 측정한 결과 추출물 모두에서 함량이 농도 의존적으로 높았으며 소거효능도 역시 높게 나타났다. vivo 생쥐 실험에서는 보통식이군(NOR), 고지방식이군(CON), 고지방식이+발효 섭취군(FHS), 고지방식이+비발효 섭취군(NFHS)으로 총콜레스테롤(total cholesterol), 중성지질(triglyceride), 고밀도 지질단백질(HDL 저밀도 지질단백질(LDL cholesterol)을 추출물은 총콜레스테롤, 지질단백질, 중성지질을 저하시키는 있는 반면 지질단백질을 상승시키는 있었다. 결론적으로 무궁화는 물질을 많이 함유하고 있어 있고...
The levels of glycosylated haemoglobins and albumin were determined in 56 diabetic patients aged between 5 19 years. glycohaemoglobin measured by two different methods, cation-exchange chromatography a colorimetric chemical method. method plasma purified with Affi-gel Blue. results compared other indicators such as blood glucose urinary glucose. postprandial well correlated the glycoproteins: column (r = 0.886), 0.72) glycoalbumin 0.662). showed weak correlation 0.214) 0.298), but no...
Background: Digital phenotypes can be utilized to predict impending panic symptoms, enabling proactive and personalized digital therapy for patients who suffer from mood anxiety problems. Current study aimed use machine learning differentiate data points on the day before (DBP) event a stable without any symptoms.Methods: This included 43 with symptoms. phenotypic data, along real-time symptoms smartphone applications wearable devices, were prospectively collected over 2-year....