A5020078138- Mitochondrial Function and Pathology
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Acute Kidney Injury Research
- Cardiac electrophysiology and arrhythmias
- ATP Synthase and ATPases Research
- Ubiquitin and proteasome pathways
- Metabolism and Genetic Disorders
- Cardiovascular Function and Risk Factors
- Cancer, Hypoxia, and Metabolism
- Bioactive Compounds and Antitumor Agents
- Chronic Kidney Disease and Diabetes
- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Sirtuins and Resveratrol in Medicine
- Pluripotent Stem Cells Research
- Sepsis Diagnosis and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular and exercise physiology
- Ion channel regulation and function
- Hormonal Regulation and Hypertension
- Organ Transplantation Techniques and Outcomes
- Coenzyme Q10 studies and effects
- Muscle and Compartmental Disorders
Inje University
2016-2025
Korea University
2000-2015
Korea University Medical Center
2004-2015
Pusan National University
2011-2014
National Medical Center
2014
Inje University Busan Paik Hospital
2008-2013
Chungbuk National University
2013
Florida State University
2011
Inje University Ilsan Paik Hospital
2008
Catholic University of Korea
2007
Background. Although neutrophils and T cells are important in mediating renal injury following ischaemia/reperfusion, the role of macrophages is still unknown. Using liposomal clodronate (LC), we investigated effect systemic monocyte–macrophage depletion on damage ischaemic acute failure rats. Methods. Male Sprague–Dawley rats were injected by LC or vehicle underwent bilateral pedicle clamping (40 min) sham ischaemia. Biochemical histological was assessed gene expression kinetics tumour...
Aldosterone induces myocardial fibrosis and vascular inflammation via proinflammatory profibrotic cytokines. The effect of spironolactone on renal function was investigated in type 2 diabetic rats. For define the molecular mechanism spironolactone, synthesis monocyte chemotactic peptide-1 (MCP-1) its upstream transcription factor, NF-kappaB, evaluated cultured mesangial cells proximal tubular cells. There were no changes blood glucose concentration or BP after treatment. Spironolactone...
Tamoxifen resistance is often observed in the majority of estrogen receptor-positive breast cancers and it remains as a serious clinical problem cancer management. Increased aerobic glycolysis has been proposed one mechanisms for acquired to chemotherapeutic agents cells such adriamycin. Herein, we report that rates LCC2 LCC9--tamoxifen-resistant human cell lines derived from MCF7--are higher than those MCF7S, which parent MCF7 subline. Inhibition key glycolytic enzyme hexokinase-2 resulted...
Abstract Dipeptidyl peptidase-4 (DPP-4) inhibitors are glucose-lowering drugs for type 2 diabetes mellitus (T2DM). We investigated whether evogliptin® (EVO), a DPP-4 inhibitor, could protect against diabetic cardiomyopathy (DCM) and the underlying mechanisms. Eight-week-old obese db/db mice were administered EVO (100 mg/kg/day) daily by oral gavage 12 weeks. control C57BLKS/J as wild-type (WT) received equal amounts of vehicle. In addition to hypoglycemic effect, we examined improvement in...
Visfatin is an adipocytokine that improves insulin resistance and has antidiabetic effect. However, the role of visfatin in kidney not yet been reported. In this experiment, synthesis physiological action cultured mesangial cells (MCs) were studied to investigate diabetic nephropathy. was found synthesized MCs as well adipocytes. markedly increased, by angiotensin II, but high glucose stimuli. addition, treatment induced a rapid uptake glucose, peaking at 20 min after dose-dependent manner....
Sepsis is the most common cause of acute kidney injury in critically ill patients; however, mechanisms leading to sepsis remain elusive. Although has been considered an excessive systemic inflammatory response, clinical trials that inhibit inflammation have shown no effect. The purpose this study was examine pathophysiology septic focusing on immune responses and renal tubular cell apoptosis by providing on-site quantitative comparison between septic- ischemia/reperfusion-induced...
This Research Article reports self-powered humidity sensors based on graphene oxide (GO) and poly(sodium 4-styrenesulfonate) (PSS)-intercalated GO composite films used as the humidity-responsive dielectrics. A hydrophilic electrically-insulating PSS polymer was an intercalant between individual platelets to enhance water permeation characteristics. Capacitive-type fabricated by forming metal electrodes both sides of GO-PSS were installed into charge pumping system, which can produce a...
Echinochrome A (Ech A) is a naphthoquinoid pigment from sea urchins that possesses antioxidant, antimicrobial, anti-inflammatory and chelating abilities. Although Ech the active substance in ophthalmic cardiac drug Histochrome®, its underlying cardioprotective mechanisms are not well understood. In this study, we investigated protective role of against toxic agents induce death rat myoblast H9c2 cells isolated cardiomyocytes. We found cardiotoxic tert-Butyl hydroperoxide (tBHP, organic...
Background. Recent studies provided evidence of the potential role CD11c+ F4/80+ dendritic subset in mediating injury and repair. The purpose this study was to examine kidney recovery phase ischaemia/reperfusion (IRI).
Yoga has been known to have stimulatory or inhibitory effects on the metabolic parameters and be uncomplicated therapy for obesity. The purpose of present study was test effect an 8-week yoga-asana training body composition, lipid profile, insulin resistance (IR) in obese adolescent boys. Twenty volunteers with mass index (BMI) greater than 95th percentile were randomly assigned yoga (age 14.7±0.5 years, n=10) control groups 14.6±1.0 n=10). group performed exercises three times per week at...
Abnormal sulfide catabolism, especially the accumulation of hydrogen (H2S) during hypoxic or inflammatory stresses, is a major cause redox imbalance-associated cardiac dysfunction. Polyhydroxynaphtoquinone echinochrome A (Ech-A), natural pigment marine origin found in shells and needles many species sea urchins, potent antioxidant inhibits acute myocardial ferroptosis after ischemia/reperfusion, but chronic effect Ech-A on heart failure unknown. Reactive sulfur (RSS), which include catenated...
<i>Background/Aims:</i> Increased susceptibility of the kidney to acute renal failure (ARF) in setting sepsis even absence systemic hypotension is well known. In hypothesis that proinflammatory cytokines and lipopolysaccharide (LPS) gram-negative can directly cause tubular cell apoptosis via Fas- caspase-mediated pathways, we examined Fas, Fas ligand, FADD expression, as PARP cleavage cultured human proximal cells under cytokine LPS-stimulated conditions....
Background. High glucose and angiotensin-II (Ang-II) levels are the known important mediators of diabetic nephropathy. However, effects these on matrix metalloproteinase-2 (MMP-2) tissue inhibitor (TIMP-2) in proximal tubule cells have yet to be fully examined within context early stage
Preservation of mitochondrial function is essential to limit myocardial damage in ischaemic heart disease. We examined the protective effects and mechanism a new compound, NecroX-5, on rat mitochondria hypoxia/reoxygenation (HR) model.NecroX-5 reduced oxidative stress, prevented collapse membrane potential, improved oxygen consumption, suppressed Ca(2+) overload during reoxygenation an vitro HR model. Furthermore, NecroX-5 ouabain- or histamine-induced increase Ca(2+).These findings suggest...
Although intraperitoneal surgery is a major operation associated with postoperative acute kidney injury (AKI), the incidence, risk factors, and long-term renal outcome are not well known. We aimed to determine factors 6 months in patients clinical or subclinical AKI after hepatobiliary surgery. also assessed validity of urine neutrophil gelatinase-associated lipocalin (NGAL) early detection prediction outcome. This prospective observational study enrolled normal function who underwent...