A5052154367- Sexual function and dysfunction studies
- Adipokines, Inflammation, and Metabolic Diseases
- Chronic Kidney Disease and Diabetes
- Advanced Glycation End Products research
- Diabetes Treatment and Management
- Cancer, Lipids, and Metabolism
- Urinary and Genital Oncology Studies
- Renin-Angiotensin System Studies
- Adipose Tissue and Metabolism
- Genital Health and Disease
- Hormonal Regulation and Hypertension
- Angiogenesis and VEGF in Cancer
- Urological Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Bladder and Urothelial Cancer Treatments
- Pancreatic function and diabetes
- Retinoids in leukemia and cellular processes
- Atherosclerosis and Cardiovascular Diseases
- Eicosanoids and Hypertension Pharmacology
- Neuropeptides and Animal Physiology
- Peroxisome Proliferator-Activated Receptors
- Sarcoma Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Hormonal and reproductive studies
- Liver Disease Diagnosis and Treatment
Inha University
2012-2023
Inha University Hospital
2012-2023
University of Massachusetts Chan Medical School
2023
University of Wisconsin–Madison
2016-2021
Virginia Commonwealth University
2016
Seoul National University Hospital
2012
Incheon Medical Center
2009
Vanderbilt University Medical Center
2007
Government of the Republic of Korea
2006
Yonsei University
1999
The NF-κB pathway plays an important role in chronic inflammatory and autoimmune diseases. Recently, has also been suggested as mechanism linking obesity, inflammation, metabolic disorders. However, there is no current evidence regarding the of action inhibition insulin resistance diabetic nephropathy type 2 animal models. We investigated effects inhibitor celastrol db/db mice. treatment with for months significantly lowered fasting plasma glucose (FPG), HbA1C homeostasis model assessment...
Despite the emerging importance of fibroblast growth factor 21 (FGF21) as a metabolic hormone regulating energy balance, its direct effects on renal function remain unexplored. FGF21 was injected ip daily for 12 weeks into db/db mice. Compared with control vehicle injection, treatment significantly improved lipid profiles and insulin resistance resulted in higher serum adiponectin levels. In contrast, 8-isoprostane levels were decreased. Interestingly, receptor components kidneys found to be...
The endocannabinoid system is important in the pathogenesis of obesity-related metabolic disorders. However, effect inhibiting type 2 diabetic nephropathy unclear. Therefore, we examined cannabinoid (CB)1 receptor antagonist, SR141716, on insulin resistance and db/db mice. Six-week-old mice were treated with CB1-specific antagonist SR141716 (10 mg/kg·d) for 3 months. Treatment significantly improved lipid abnormalities. Concomitantly, CB1 antagonism cardiac functional morphological...
Cytosolic proteins are required for regulation of NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (Nox) isozymes. Here we show that Src homology 3 (SH3) domain-containing YSC84-like 1 (SH3YL1), as a Nox4 cytosolic regulator, mediates lipopolysaccharide (LPS)-induced H2O2 generation, leading to acute kidney injury. The SH3YL1, Ysc84p/Lsb4p, Lsb3p, and plant FYVE (SYLF) region SH3 domain SH3YL1 contribute formation complex with Nox4-p22phox. Interaction p22phox is triggered by LPS,...
Background. Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription factors that play a role in insulin sensitivity, lipid metabolism and inflammation. However, the effects of PPARγ agonist on renal inflammation have not been fully examined type 2 diabetic nephropathy. Methods. In present study, we investigated effect molecular mechanism agonist, pioglitazone, progression nephropathy rats. Inflammatory markers including NF-κB, MCP-1 pro-fibrotic cytokines were...
Visfatin is an adipocytokine that improves insulin resistance and has antidiabetic effect. However, the role of visfatin in kidney not yet been reported. In this experiment, synthesis physiological action cultured mesangial cells (MCs) were studied to investigate diabetic nephropathy. was found synthesized MCs as well adipocytes. markedly increased, by angiotensin II, but high glucose stimuli. addition, treatment induced a rapid uptake glucose, peaking at 20 min after dose-dependent manner....
Abstract Chronic inflammation caused by high glucose and free fatty acid (FFA) concentrations is a major contributor to the pathogenesis of type 2 diabetes. Recent evidence suggests that activation Toll-like receptor (TLR) signaling induces peripheral insulin resistance mediates central leptin resistance. In this study, we investigated renal effects TLR4 blockade in diabetic mice. Eight-week-old db/db mice were treated for 12 weeks with (S,R)-3-phenyl-4,5-dihydro-5-isoxasole acetic (GIT27),...
Background. High glucose and angiotensin-II (Ang-II) levels are the known important mediators of diabetic nephropathy. However, effects these on matrix metalloproteinase-2 (MMP-2) tissue inhibitor (TIMP-2) in proximal tubule cells have yet to be fully examined within context early stage
Angiotensin type 1 (AT1) receptor blocker (ARB) ameliorates progression of chronic kidney disease. Whether this protection is due solely to blockade AT1, or whether diversion angiotensin II from the AT1 available AT2 receptor, thus potentially enhancing effects, not known. We therefore investigated role in ARB-induced treatment effects Adult rats underwent 5/6 nephrectomy. Glomerulosclerosis was assessed by renal biopsy 8 wk later, and were divided into four groups with equivalent...
Although the pathogenetic mechanism of diabetic nephropathy has not been elucidated, an inflammatory suggested to contribute its progression. Monocyte chemoattractant peptide (MCP)‐1 attracts macrophages and T cells, ultimately injures renal tissue. In early nephropathy, urinary excretion MCP‐1 was elevated, increased as damage became more severe. Podocytes are expected have role in surface expression chemokine receptors such CCR CXCR on these cells recently reported. retinoid (retinal), a...
Vascular endothelial growth factor (VEGF) has been implicated in the pathogenesis of diabetic nephropathy. We investigated serial changes VEGF kidney and assessed whether glomerular urinary levels are related to severity Furthermore, we examined relationship between albumin excretion (UAE) rate Otsuka-Long-Evans-Tokushima-Fatty (OLETF) rats. Glomerular mRNA expression protein synthesis were evaluated by reverse transcription-polymerase chain reaction, immunohistochemical staining situ...
Peroxisome proliferator–activated receptors (PPARs) are nuclear transcription factors and play a central role in insulin sensitivity, lipid metabolism, inflammation. Both PPARα -γ expressed the kidney, their agonists exhibit renoprotective effects type 2 diabetes. In present studies, we investigated effect of PPARα/γ dual agonist tesaglitazar on diabetic nephropathy db/db mice. Treatment mice with for 3 months significantly lowered fasting plasma glucose homeostasis model assessment...
Recent data suggest that aldosterone antagonists have beneficial effects on diabetic nephropathy. In this study, we investigated the dose-dependent effect of eplerenone and a combined treatment with enalapril compared each drug alone renal function in type II rats. To further explore molecular mechanism action combination therapy, also performed vitro study.The animals were divided into six groups as follows: normal control Long-Evans Tokushima Otsuka (LETO) rats, Fatty (OLETF) OLETF rats...
Background. Aliskiren is a direct renin inhibitor (DRI) and provides an organ-protective effect in human animal experiments. However, there no current evidence of the DRI on insulin resistance metabolic abnormalities type 2 diabetic animals.