A5038668801- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Systemic Sclerosis and Related Diseases
- Angiogenesis and VEGF in Cancer
- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Cardiac Imaging and Diagnostics
- Erythropoietin and Anemia Treatment
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Function and Risk Factors
- Food Quality and Safety Studies
- Biomarkers in Disease Mechanisms
- Liver Disease Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Lymphatic System and Diseases
- Hydrogen's biological and therapeutic effects
- Heart Failure Treatment and Management
- Advanced Glycation End Products research
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Renin-Angiotensin System Studies
- Aldose Reductase and Taurine
- Kawasaki Disease and Coronary Complications
Tokyo Women's Medical University Adachi Medical Center
2008-2021
Tokyo Rosai Hospital
2016-2021
Osaka City General Hospital
2012-2013
Osaka Prefectural Medical Center
2013
Tokyo Women's Medical University Hospital
2003-2005
Showa University Fujigaoka Hospital
2003
Tonan Hospital
2003
Chiba University
1986-2001
Nagasaki University
1999-2001
Tohoku University
2000
The effect of each twelve mammalian lignan derivatives on the growth human mammary tumor ZR-75-1 cells was examined. At a concentration less than 10 micrograms/ml, cell inhibited from 18-68%. 2,3-dibenzylbutane-1,4-diol(hattalin) found to be strongest, inhibiting by 50% at (EC50) 2.1 micrograms/ml. Hattalin membrane Na+, K(+)-ATPase canine kidney cortex. It also ATPase plasma fraction both cultured and section breast cancer tissue ranging 0.5 2.0 mM. However, only few percent either or...
Angiotensin type 1 (AT1) receptor blocker (ARB) ameliorates progression of chronic kidney disease. Whether this protection is due solely to blockade AT1, or whether diversion angiotensin II from the AT1 available AT2 receptor, thus potentially enhancing effects, not known. We therefore investigated role in ARB-induced treatment effects Adult rats underwent 5/6 nephrectomy. Glomerulosclerosis was assessed by renal biopsy 8 wk later, and were divided into four groups with equivalent...
Both podocytes and glomerular endothelial cells (GEN) are postulated to play important roles in the progression potential regression of glomerulosclerosis. Inhibition angiotensin is crucial treatment chronic kidney disease, presumably via effects on BP extracellular matrix. This study aimed investigate how inhibition altered interactions between GEN. The supernatants from primary cultured mouse podocytes, before or after sublethal injury by puromycin aminonucleoside, presence absence type 1...
Identification of patients with chronic heart failure (CHF) at a risk for sudden cardiac death (SCD) is an important objective. Early repolarization pattern (ERP) associated ventricular fibrillation in without structural diseases. Moreover, ERP was reported to be SCD old myocardial infarction case-control study. However, little information available on the prognostic significance CHF patients. Thus, we aimed investigate whether patients.The study population consisted 132 consecutive...
Abstract. The ets-1 proto-oncogene is a member of the transcriptional factor family and was identified by homology to v-ets oncogene. It recently demonstrated that Ets-1 protein interacts with promoter region genes coding for proteinases, including matrix metalloproteinase-1 (MMP-1), MMP-3, urokinase-type plasminogen activator, suggesting it may play an important role in regulation MMP expression. advanced glomerular diseases, where extracellular accumulation observed, remains undefined. In...
Abstract: Nonphysiological solutions containing high glucose levels have been considered an important factor in the etiology of fibrotic changes long‐term continuous ambulatory peritoneal dialysis (CAPD) patients. At same time, increased Plasminogen Activator Inhibitor (PAI)‐1 secretion has reported to correlate with changes. We suspected that content solution may induce sclerosis via up‐regulation PAI‐1 gene expression. In this study, we evaluated effects on activity fibrosis a rat model...
The development of a glucose-free peritoneal dialysis (PD) solution is important because glucose has been associated with functional and morphological damage to the membrane. ultrafiltration (UF) biocompatibility new PD solutions containing taurine (PD-taurine) instead as an osmolite were tested in rat model.To determine solution's UF ability, different concentrations compared glucose-based (PD-glucose) by giving single intraperitoneal injections for 2, 4, 6 hours. To examine PD-taurine,...
<i>Background:</i> In vitro studies have shown that pH and glucose degradation products (GDPs) in the dialysate are determinant factors for biocompatibility of peritoneal dialysis (PD) treatment. The present study was thus designed to evaluate whether a newly developed PD solution, which features neutral levels low GDP concentration, influences tissue damage membrane an vivo setting, factor is more critical histological changes. <i>Methods:</i> Rats were injected 3...
We investigated whether a high glucose condition could affect cholesterol ester (CE) synthesis and accumulation of in arterial wall cells by using the human monocytic cell line THP-1. After 24-hour PMA treatment, were grown control (200 mg/dl glucose) or concentration (400, 600, 800, 1,600 mg/dl) medium for 6 days. CE was then incubated with 50 microg/ml native, glycated, acetylated, oxidized LDL. Cells 400 showed significant increase regardless they glycated LDL, compared 200 glucose. In...
Background.Ets-1 proto-oncogene exhibits multiple activities in the transcriptional regulation of numerous genes including metalloproteinase (MMP)-1, -3 and -9. MMPs play an important role remodelling extracellular matrix various renal diseases. However, Ets-1–MMP axis advanced diseases is uncertain. In present study, we investigated whether Ets-1 involved interleukin (IL)-1-mediated expression tubulointerstitial cells. Methods. Rat fibroblasts (NRK-49F) tubular epithelial cells (NRK-52E)...
Circulating endothelial progenitor cells (EPCs) play a pivotal role in vasculogenesis and promote angiogenesis by secreting growth factors. Recent studies have suggested that erythropoietin (EPO) may accelerate not only but also vasculogenesis, beyond erythropoiesis. The aim of this study was to investigate whether two erythropoiesis-stimulating agents (ESAs) modulate vascular-related factors EPC mobilization patients with chronic kidney disease stage G5 dialysis (CKD 5D).We conducted...
症例は49歳, 男性. 糖尿病性腎症により血液透析導入され, 5年前にCMLと診断され, 第一世代TKIであるイマチニブ400mg/日の内服が開始された. 3年間の長期内服後, 急速に進行する両側手指の壊死性潰瘍が多発し入院となった. 内科治療に反応せず最終的に手指の切断に至った. 病理組織では, 中膜の石灰化は軽度で, 血管内膜の線維性肥厚が強く内腔が狭小化しており, 内膜の浮腫性肥厚を特徴とするカルシフィラキシスとは一致しなかった. 血管障害の成因として, イマチニブの休薬・再開と潰瘍の病勢が一致していることから, イマチニブによる血管障害が病態の中心にあると診断した. 近年第二世代TKIであるニロチニブによる末梢動脈障害の報告を認めるが, イマチニブの血管障害の危険性は比較的少ないとされている. 透析・糖尿病という潜在的血管障害や腎不全による代謝低下を有する維持透析患者では, イマチニブによる血管障害が顕在化する可能性が臨床的に示された.
集中治療における持続血液浄化法 (continuous blood purification, CBP) 施行中の血小板数減少の発生要因についてretrospectiveに検討した.1回平均8時間以上の持続血液濾過透析 (CHDF) もしくは持続血液濾過 (CHF) を2日以上施行した27症例 (延べ161回) を対象とした. CBP施行中に血小板が開始前値に比べ30%以上の減少を認めた群 (血小板減少あり群N=12), 認めなかった群 (血小板減少なし群N=15) の2つに群分けし, 比較検討した. 検討項目はCHDF/CHF条件としてヘモフィルターおよび抗凝固剤の種類, QD(mL/hr), QF(mL/hr), 血液流量分の濾液流量 (濾過率) QF/QB (%), フィルター使用時間 (hr) の6項目, CBP導入前データとしてAPACHE IIスコア, DICスコア, プロトロンビン時間 (秒), フィブリノーゲン (mg/dL), FDP (μg/mL), 白血球数 (/μL), 血小板数 (×104/μL), ヘマトクリット値 血清クレアチニン濃度...