A5100320420- Acne and Rosacea Treatments and Effects
- Herpesvirus Infections and Treatments
- Dermatologic Treatments and Research
- Nail Diseases and Treatments
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Healthcare and Venom Research
- melanin and skin pigmentation
- Cutaneous lymphoproliferative disorders research
- Facial Rejuvenation and Surgery Techniques
- Cancer Cells and Metastasis
- Cancer and Skin Lesions
- Skin Protection and Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Hair Growth and Disorders
- Contact Dermatitis and Allergies
- Laser Applications in Dentistry and Medicine
- 3D Printing in Biomedical Research
- Retinoids in leukemia and cellular processes
- Antimicrobial Peptides and Activities
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetic and rare skin diseases.
- Corneal Surgery and Treatments
- Spine and Intervertebral Disc Pathology
Catholic University of Korea
2012-2025
Seoul St. Mary's Hospital
2025
Soonchunhyang University
2012-2024
Agency for Defense Development
2024
Daewoong Pharmaceutical (South Korea)
2024
Bio-Medical Science (South Korea)
2023
Chung-Ang University
2011-2023
Hallym University
2005-2022
Hallym University Kangnam Sacred Heart Hospital
2020-2022
Naver (South Korea)
2020
Background Outer root sheath cells (ORSCs) play important roles in maintaining hair follicle structure and provide support for the bulge area. The growth promoting effects of photobiomodulation therapy (PBMT) have been reported, but mechanisms this human ORCs (hORSCs) rarely studied. Objective aim study was to investigate effect various wavelengths light‐emitting diode (LED) irradiation on ORSCs (hORSCs). Methods LED hORSC proliferation migration were examined with MTT assay, BrdU...
Atopic dermatitis is a chronic skin disease affecting quality of life, sleep, and mental health. Traditional evaluation methods focus on clinical assessments, but there growing need for tools that incorporate patient-reported outcomes (PROs). To evaluate the effectiveness Dermatitis Control Tool (ADCT) in assessing severity patients with moderate to severe atopic compare efficacy systemic immunosuppressants dupilumab dermatitis. A prospective, observational study was conducted across seven...
Application of machine learning (ML) on cancer-specific pharmacogenomic datasets shows immense promise for identifying predictive response biomarkers to enable personalized treatment. We introduce CAN-Scan, a precision oncology platform, which applies ML next-generation generated from freeze-viable biobank patient-derived primary cell lines (PDCs). These PDCs are screened against 84 Food and Drug Administration (FDA)-approved drugs at clinically relevant doses (Cmax), focusing colorectal...
<b><i>Background:</i></b> The pathophysiology of transient global amnesia (TGA) is not fully understood. This study was conducted to identify the cardiovascular risk factors TGA compared those ischemic attack (TIA) and normal controls, using a large number subjects. In addition comparison factors, an association between observed in current pathophysiological mechanism recently investigated speculated upon. <b><i>Materials Methods:</i></b> We...
Defensins, a prominent group of antimicrobial peptides, are an important component the innate immune response, particularly at mucosal surfaces that vulnerable to colonization by potential pathogens. The present study was undertaken investigate expression defensins in inferior turbinate mucosa normal subjects and nasal polyps patients with chronic sinusitis. Expression β-defensin 1 2 α-defensin 5 6 messenger RNAs (mRNAs) investigated reverse transcriptase–polymerase chain reaction, their...
Kummell's disease, caused by osteonecrosis of the vertebral body, is a cause collapse. In intravertebral instability from nonunion between cement and bone after percutaneous vertebroplasty (PVP) can persistent severe pain dysfunction. A 75-year-old woman presented with in lower back, both buttocks, groin, posterior thighs for period 30 days. Lumbar radiographs magnetic resonance images showed an acute compression fracture first lumbar vertebra cleft filled fluid. The patient underwent PVP L1...
Acne vulgaris is one of the most common disorders pilosebaceous unit. Although doxycycline considered to be a first-line anti-acne antibiotic, various other antibiotics have been tried due its adverse effects and contraindications. We performed meta-analysis randomized controlled trials (RCTs) that compared efficacy oral azithromycin pulse therapy with daily in management moderate severe acne vulgaris. Five scientific databases (MEDLINE, EMBASE, Cochrane Library, SCOPUS, Web Science) were...
Background Malignant melanoma is a cutaneous malignancy with high mortality rate and potential for metastases. Detailed information on the clinicopathologic characteristics prognostic factors of currently limited in Korea. This study aimed to identify epidemiological primary Korean patients, assess which variables could influence both development metastases overall survival (OS). Methods A total 261 patients diagnosed seven medical centers between 1997 2017 were retrospectively investigated...
Hyaluronic acid dermal fillers are most frequently used for unwanted wrinkles. Recently, lidocaine has been incorporated into hyaluronic to reduce injection discomfort.A randomized, multicenter, double-blind, intraindividual trial was designed compare a new lidocaine-containing monophasic filler (Neuramis Deep Lidocaine) with biphasic (Restylane Perlane-L) in moderate severe nasolabial folds. Fifty-eight patients folds were randomized an of Neuramis or Perlane-L the left right side face....
Inflammation triggered by the innate immune system is a strategy to protect organisms from risk of environmental infection. However, it has recently become clear that inflammation can cause variety human diseases, including cancer. In this study, we investigated effects an ethanol extract Antarctic freshwater microalgae, Chloromonas reticulata (ETCH), on and carcinogenesis in RAW 264.7 macrophages HCT116 colon cancer cells, respectively. ETCH exhibited significant anti-inflammatory activity...
Three-dimensional (3D) culture platforms have been adopted in a high-throughput screening (HTS) system to mimic vivo physiological microenvironments. The automated dispenser has established commercially enable spotting or distributing non-viscous viscous biomaterials onto microplates. However, there are still challenges the precise and accurate dispensation of cells embedded hydrogels such as Alginate- Matrigel-extracellular matrices. We developed improved an contact-free dispensing machine,...
Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperproliferation, aberrant differentiation of keratinocytes, and dysregulated immune responses. WW domain-containing oxidoreductase (WWOX) non-classical tumor suppressor gene that regulates multiple cellular processes, including proliferation, apoptosis, migration. This study aimed to explore the possible role WWOX in pathogenesis psoriasis. Immunohistochemical analysis showed expression was increased keratinocytes...
This study examined the chemical composition of Neolitsea aciculata essential oil (NAE) and its biological activities. NAE was obtained by hydro-distillation N. leaves collected in Jeju Island analyzed gas chromatography equipped with a mass spectrometer detector. 1-Dodecen-3-yne (12.5%), calarene (11.5%) elemol (9.5%) were identified as major components NAE. The antibacterial anti-inflammatory activities against skin pathogens to determine protective properties acne vulgaris. exhibited...
Research on the epidemiology of monoclonal gammopathy undetermined significance (MGUS) is limited in Korea. The aim this study was to determine prevalence and characteristics MGUS an elderly urban Korean population. A random sample 1118 elders selected from residents aged 65 years or older living Seongnam, Korea 1 year August 2005. We obtained plasma samples remaining after scheduled tests for Longitudinal Study Health Aging. mean age population 72 (range, 65-97 years). To screen MGUS,...
Despite early treatment of herpes zoster (HZ), postherpetic neuralgia (PHN) can persist. This study was designed to compare the therapeutic and pain relief effects continuous epidural analgesia (CEA) on chronic phase as well acute HZ with standard medical treatment.Medical records 227 patients moderate severe zoster-associated that had not responded medications were retrospectively reviewed. Patients received alone (medical group) or plus concurrent CEA (epidural group). The groups...
Visfatin is a known adipokine which may improve insulin resistance in obesity and have an anti-diabetic effect via the receptor. We studied effects of visfatin on diabetic nephropathy type 2 mice.Diabetic male db/db mice were treated with intraperitoneal injections visfatin. Basal parameters measured all glucose tolerance test (GTT) (ITT) performed mice. The histopathological molecular changes evaluated nephropathy.Visfatin treatment had no body weight, water food intake, urinary volume,...
For the diagnosis of essential thrombocythemia (ET), no single clinical or laboratory finding diagnostic value is available and a differential other myeloproliferative neoplasms reactive thrombocytosis (RT) needed. Following recent developments in automated blood cell analyzers, various platelet indices can now be measured. In this study, we analyzed whether counts 6 used for differentiation ET from RT patients with count 600x10(3)/microL more.The subjects studied were 31 224 RT. The counts,...
The aryl hydrocarbon receptor (AHR) and autophagy are both important to maintain skin homeostasis. However, they also involved in disorders. So far, their roles psoriasis pathogenesis unknown.We studied the immunohistochemical gene expression of AHR, CYP1A1, microtubule-associated protein light chain 3 (LC3) lesional patients determine correlations among them.We included 24 ten healthy volunteers. Skin biopsies were collected. LC3 was examined by immunohistochemistry, immunofluorescence,...