A5037929858- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Kruppel-like factors research
- TGF-β signaling in diseases
- PI3K/AKT/mTOR signaling in cancer
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Cellular transport and secretion
- Caveolin-1 and cellular processes
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Protein Kinase Regulation and GTPase Signaling
- Cancer-related Molecular Pathways
- Phosphodiesterase function and regulation
- Advanced Radiotherapy Techniques
- Helicobacter pylori-related gastroenterology studies
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Signaling Pathways in Disease
- Amino Acid Enzymes and Metabolism
- Innovative Microfluidic and Catalytic Techniques Innovation
- DNA Repair Mechanisms
- Receptor Mechanisms and Signaling
- Endoplasmic Reticulum Stress and Disease
Bio-Medical Science (South Korea)
2023
The University of Texas Southwestern Medical Center
2021-2023
Harold C. Simmons Comprehensive Cancer Center
2023
Center for Neuroscience and Regenerative Medicine
2023
Yonsei University
2015-2019
University of Ulsan
2012-2016
Ulsan College
2012-2016
Asan Medical Center
2016
// Mi-Hyeon Jeong 1, 4, * , Hyeonseok Ko 5, Hyelin Jeon 2 Gi-Jun Sung Soo-Yeon Park 4 Woo Jin Jun 6 Yoo-Hyun Lee 7 Jeongmin 8 Sang-wook 9 Ho-Geun Yoon Kyung-Chul Choi 2, 3 1 Department of Biomedical Sciences, Asan Medical Center, University Ulsan College Medicine, Seoul, Korea Pharmacology, Cell Dysfunction Research Center (CDRC), South Biochemistry and Molecular Biology, for Chronic Metabolic Disease Research, Brain 21 Plus Project Severance Institute, Yonsei 5 Laboratory Oncology, Cheil...
Abstract The inhibition of p53 activity by histone deacetylase 3 (HDAC3) has been reported, but the precise molecular mechanism is unknown. Here we show that programmed cell death 5 (PDCD5) selectively mediates HDAC3 dissociation from p53, which induces cleavage and ubiquitin-dependent proteasomal degradation. Casein kinase 2 alpha phosphorylates PDCD5 at Ser-119 to enhance its stability importin 13-mediated nuclear translocation PDCD5. Genetic deletion abrogates etoposide (ET)-induced...
// Hyeonseok Ko 5,* , Mi-Hyeon Jeong 1,4,* Hyelin Jeon 1 Gi-Jun Sung Youngsin So InKi Kim 3 JaeKyoung Son Sang-wook Lee 2 Ho-Geun Yoon 4 Kyung-Chul Choi Department of Biomedical Sciences and Pharmacology, University Ulsan College Medicine, Seoul, Korea Radiation Oncology, Asan Medical Center, Institute for Research, South Biochemistry Molecular Biology, Brain PLUS Project Sciences, Yonsei 5 Laboratory Cheil General Hospital & Women's Healthcare Dankook University, * These authors are...
Because of disease heterogeneity, limited studies on effective chemotherapies and therapeutic agents for advanced gastric cancer are available. Erythrocyte membrane protein band 4.1-like 5 (EPB41L5) has critical roles in renal breast metastasis. However, its role metastatic remains unknown.The specimens 78 patients were analyzed by oligonucleotide microarray survival analysis. In vitro experiments mice models used to assess the effects EPB41L5 metastasis.Gastric with high levels had poor...
The mammalian target of rapamycin complex 1 (mTORC1) integrates nutrients, growth factors, stress, and energy status to regulate cell metabolism. Amino acids promote mTORC1 lysosomal localization subsequent activation. However, the subcellular location or interacting proteins under amino acid-deficient conditions is not completely understood. Here, we identify ADP-ribosylation factor GTPase-activating protein (ArfGAP1) as a crucial regulator mTORC1. ArfGAP1 interacts with in absence inhibits...
Significance The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway is frequently elevated in human disease, including cancer, type 2 diabetes, metabolic disorders, and neurodegeneration. We identify SNAT7 as an important regulator mTORC1. believe this research will provide valuable insight about mTORC1 biology may uncover novel therapeutic targets for patients.
The mammalian target of rapamycin complex 1 (mTORC1) senses multiple upstream stimuli to orchestrate anabolic and catabolic events that regulate cell growth metabolism. Hyperactivation mTORC1 signaling is observed in human diseases; thus, pathways suppress may help identify new therapeutic targets. Here, we report phosphodiesterase 4D (PDE4D) promotes pancreatic cancer tumor by increasing signaling. GPCRs paired Gαs proteins activate adenylyl cyclase, which turn elevates levels 3',5'-cyclic...
The mammalian target of rapamycin complex 1 (mTORC1) senses multiple stimuli to regulate anabolic and catabolic processes. mTORC1 is typically hyperactivated in human diseases such as cancer type 2 diabetes. Extensive research has focused on signaling pathways that can activate growth factors amino acids. However, less known about cues directly inhibit activity. Here, we identify A-kinase anchoring protein 13 (AKAP13) an binding protein, a crucial regulator inhibition by G-protein coupled...
Three-dimensional (3D) culture platforms have been adopted in a high-throughput screening (HTS) system to mimic vivo physiological microenvironments. The automated dispenser has established commercially enable spotting or distributing non-viscous viscous biomaterials onto microplates. However, there are still challenges the precise and accurate dispensation of cells embedded hydrogels such as Alginate- Matrigel-extracellular matrices. We developed improved an contact-free dispensing machine,...
Abstract Protein Kinase A (PKA) phosphorylates diverse protein substrates to modulate their function. In this study, we found that PKA specifically the RD1 (Repression Domain 1) domain of nuclear receptor corepressor (NCoR). We demonstrated Serine‐70 NCoR is identified critical amino acid for PKA‐dependent phosphorylation. Importantly, phosphorylation enhances translocation NCoR. More importantly, activation enhanced repressive activity in a reporter assay and potentiated antagonist Androgen...
Significance Programmed cell death 5 (PDCD5) plays a pivotal role in cellular apoptosis. Pathological relevance of PDCD5 is mostly found human cancers; however, the noncancerous diseases not fully elucidated. Here we show that mice with endothelial deficiency have elevated serum nitric oxide levels and an atheroprotective effect blood vessels. In addition, disrupts HDAC3–protein kinase B (PKB/AKT) interaction inhibits AKT-eNOS signaling production vivo vitro. Moreover, reflects vascular...
Abstract The role of histone deacetylase 3 (HDAC3) is to repress the expression various genes by eliminating acetyl group from histone. Thus, regulation HDAC3 activity essential maintain cellular homeostasis. In this study, we found that interacts with c‐Src kinase. However, interaction between and was previously reported, it has still been ambiguous whether phosphorylates affects function HDAC3. First, confirmed directly binds c‐Src, identified interact C‐terminal domain (277–428 a.a.) also...
Jaesung Seo, Hyun Jung Kee, Hye Ji Choi, Jae Eun Lee, Soo-Yeon Park, Seung-Hyun Mi-Hyeon Jeong, Garam Guk, SooYeon Kyung-Chul Yoon Young Hyunki Kim, Sung Hoon Noh, Ho-Geun Yoon, and Jae-Ho Cheong. BMB Reports 2018;51:255-60. https://doi.org/10.5483/BMBRep.2018.51.5.046
Abstract Gastric cancer is the fourth most common worldwide. Despite high incidence of gastric cancer, efficient chemotherapy treatments still need to be developed. In this study, we examined anticancer effects endoplasmic reticulum (ER) stress inducer tunicamycin in cancer. Previously, found that overexpression WLS1/GPR177 correlated with poor prognosis patients Furthermore, treatment downregulated GPR177 expression a dose‐dependent manner. transports WNT ligand from ER plasma membrane,...
Although programed cell death 5 (PDCD5) is an important protein in p53-mediated proapoptotic signaling, very little known about PDCD5-related death. In this study, we report that serine/threonine kinase 31 (STK31) interacts with PDCD5, which maintains the stability of PDCD5. STK31 overexpression significantly activated PDCD5 stabilization and apoptosis response to etoposide (ET). However, knockdown did not enhance by ET treatment. Moreover, when was depleted, inhibited activation p53...
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<div>AbstractPurpose:<p>Because of disease heterogeneity, limited studies on effective chemotherapies and therapeutic agents for advanced gastric cancer are available. Erythrocyte membrane protein band 4.1-like 5 (EPB41L5) has critical roles in renal breast metastasis. However, its role metastatic remains unknown.</p>Experimental Design:<p>The specimens 78 patients were analyzed by oligonucleotide microarray survival analysis. <i>In vitro</i> experiments...
<div>AbstractPurpose:<p>Because of disease heterogeneity, limited studies on effective chemotherapies and therapeutic agents for advanced gastric cancer are available. Erythrocyte membrane protein band 4.1-like 5 (EPB41L5) has critical roles in renal breast metastasis. However, its role metastatic remains unknown.</p>Experimental Design:<p>The specimens 78 patients were analyzed by oligonucleotide microarray survival analysis. <i>In vitro</i> experiments...
<p>Supplementary Data_Tracked Changes</p>
<p>Supplementary Data_Clean</p>