A5078229246- TGF-β signaling in diseases
- Cancer-related gene regulation
- Kruppel-like factors research
- Protein Kinase Regulation and GTPase Signaling
- Enzyme Structure and Function
- Cancer-related molecular mechanisms research
- Air Quality and Health Impacts
- Caveolin-1 and cellular processes
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- Metal complexes synthesis and properties
- NF-κB Signaling Pathways
- Sirtuins and Resveratrol in Medicine
- Toxin Mechanisms and Immunotoxins
- Bacteriophages and microbial interactions
- Cell Adhesion Molecules Research
- Wnt/β-catenin signaling in development and cancer
- Drug Transport and Resistance Mechanisms
- Biomarkers in Disease Mechanisms
- Microbial Natural Products and Biosynthesis
- Plant biochemistry and biosynthesis
- Echinoderm biology and ecology
University of Ulsan
2017-2024
Asan Medical Center
2017-2024
Ulsan College
2017-2024
Korea Research Institute of Bioscience and Biotechnology
2017-2022
Weatherford College
2022
Gyeongsang National University
2011-2014
Chungbuk National University
1997
Epigenetic regulations frequently appear in Glioblastoma (GBM) and are highly associated with metabolic alterations. Especially, Histone deacetylases (HDACs) correlates the regulation of tumorigenesis cell metabolism GBM progression, HDAC inhibitors report to have therapeutic efficacy other neurological diseases; however, prevention therapy by inhibition lacks a mechanism focus reprogramming.HDAC2 express is analyzed TCGA/GEPIA databases. Therefore, HDAC2 knockdown affects death. Analysis...
Although many cohort studies have reported that long-term exposure to particulate matter (PM) can cause lung cancer, the molecular mechanisms underlying PM-induced increase in cancer metastasis remain unclear. To determine whether PM contributes metastasis, cells were cultured with conditioned medium from PM-treated THP1 cells, and migration ability of treated was assessed. The key molecules involved identified using RNA-seq analysis. In addition, metastatic analyzed vivo by injection into...
Rho GDP dissociation inhibitor 2 (RhoGDI2) expression is correlated with tumor growth, metastasis and chemoresistance in gastric cancer. However, the mechanisms by which RhoGDI2 promotes cell survival remain unclear. In this study, we clearly demonstrate that upregulates VEGF-C positively human tissues as well parental cancer lines. depletion suppressed RhoGDI2-induced sensitized RhoGDI2-overexpressing cells to cisplatin-induced apoptosis vitro vivo. Secreted enhanced invasion conferred...
// Hee Jun Cho 1,* , Sun-Mi Park In-Kyu Kim In-Koo Nam Kyoung Eun Baek 1 Min-Ju Im Jong-Min Yoo Seung-Ho Ki-Jun Ryu Hyun-Tak Han Hyo-Jin Soon-Chan Hong 2 Kwang Dong Yunbae Pak Jae Won Chang Lee and Jiyun Division of Applied Life Science (BK21 plus), Research Institute Sciences, Gyeongsang National University, Jinju, Korea Department Surgery, School Medicine, * These authors contributed equally to the work Correspondence: Yoo, email: Keywords : RhoGDI2, EMT, Snail, gastric cancer, invasion...
Abstract Glioblastoma multiforme (GBM), the most aggressive and malignant glioma, has a poor prognosis. Although patients with GBM are treated surgery, chemotherapy, radiation therapy, is highly resistant to treatment, making it difficult expensive treat. In this study, we analyzed Gene Expression Profiling Interactive Analysis dataset, Cancer Genome Atlas Omnibus array data. ZBTB7A (also called FBI1/POKEMON/LRF) was found be expressed in low-grade glioma but significantly downregulated GBM....
Rho GDP dissociation inhibitor 2 (RhoGDI2) was initially identified as a regulator of the family GTPases. Our recent works suggest that RhoGDI2 promotes tumor growth and malignant progression, well enhances chemoresistance in gastric cancer. Here, we delineate mechanism by which cancer cell invasion using two-dimensional gel electrophoresis (2-DE) on proteins derived from RhoGDI2-overexpressing SNU-484 human line control cells. Differentially expressed were matrix-assisted laser desorption...
Obesity is the most common metabolic disease in developed countries and has become a global epidemic recent years. associated with various abnormalities, including glucose intolerance, insulin resistance, type 2 diabetes, dyslipidemia, hypertension. Leaves from plant Dendropanax morbiferus are beneficial to health as they contain high levels of vitamin C tannin. There have been seminal studies on anticancer, antimicrobial, antidiabetes, antihyperglycemic effects treatments D. trees. Herein,...
Tumor necrosis factor-α (TNF-α) plays a significant role in inflammation and cancer-related apoptosis. We identified TNF-α-mediated epigenetic mechanism of apoptotic cell death regulation estrogen receptor-α (ERα)-positive human breast cancer cells. To assess the effect TNF-α, annexin V/ propidium iodide (PI) double staining, viability assays, Western blotting were performed. elucidate this mechanism, histone deacetylase (HDAC) activity assay immunoprecipitation (IP) conducted; was...
Porphyra tenera, also known as nori, is a red algal species of seaweed. It cultivated in Asia for culinary purposes. We report that P. tenera extract (PTE) enhances the immune response mouse macrophages. found regulates NF-κB IκB kinase (IKK) signaling pathway, and we assessed expression translocation p65, subunit NF-κB, RAW264.7 macrophage cells after treatment with PTE. investigated effects 10% ethanol PTE (PTE10) cells. The production IL-10, IL-6, TNF-α, IFN-γ was induced by macrophages,...
// In-Kyu Kim 1,* , Sun-Mi Park Hee Jun Cho Kyoung Eun Baek 1 In-Koo Nam Seung-Ho Ki-Jun Ryu Jinhyun 2 Jungil Choi Soon-Chan Hong 3 Jae Won Chang Lee Sang Soo Kang and Jiyun Yoo Division of Applied Life Science/Research Institute Science, Graduate School Gyeongsang National University, Jinju, Korea. Department Anatomy Neurobiology, Health Medical Research Center for Neural Dysfunction, Medicine, Surgery, * Contributed equally to this work. Correspondence: Yoo, email: Kang, Keywords :...
The nuclear factor-κB (NF-κB) signalling pathway plays a critical role in the pathogenesis of multiple vascular diseases. However, endothelial cells (ECs), molecular mechanisms responsible for negative regulation NF-κB are poorly understood. In this study, we investigated novel protein tyrosine phosphatase type IVA1 (PTP4A1) ECs.In human tissues, umbilical artery ECs, and mouse models loss function gain PTP4A1, conducted histological analysis, immunostaining, laser-captured microdissection...
Abstract TP53-induced glycolysis and apoptosis regulator (TIGAR) regulates redox homeostasis provides the intermediates necessary for cell growth by reducing glycolytic rate. During cellular senescence, cells undergo metabolic rewiring towards pathway, along with development of senescence-associated secretory phenotype (SASP), also known as secretome. We observed that TIGAR expression increased during replicative senescence following in vitro expansion human mesenchymal stromal (MSCs)...
Abstract Malignant melanoma is a fatal disease that rapidly spreads to the whole body. Treatments have limited efficiency owing drug resistance and various side effects. Pseudomonas syringae pv. tomato ( Pto ) model bacterial pathogen capable of systemic infection in plants. injects effector protein HopQ into plant cytosol via type III secretion machinery suppresses host immunity. Intriguingly, proteins regulated by are conserved even humans conferred tumor metastasis. Nevertheless,...
Transforming growth factor-β1 (TGF-β1) is highly expressed in the tumor microenvironment and known to play a multifunctional role cancer progression. In addition, TGF-β1 promotes metastasis by inducing epithelial–mesenchymal transition (EMT) variety of tumors. Thus, inhibition considered an important strategy treatment cancer. most tumors, signal transduction exhibits modified or non-functional characteristics, inhibitors have various inhibitory effects on cells. Currently, many studies are...
Tamoxifen is widely used as a medication for estrogen receptor α (ERα)-positive breast cancer, despite the ~50% incidence of tamoxifen resistance. To overcome such resistance, combining with other agents considered an effective approach. Here, through in vitro studies ER-positive MCF7 cells and ER-negative MDA-MB-231 cells, validated by use xenograft mice, we investigated potential tumor necrosis factor (TNFα) to enhance sensitivity identified NCOR1 key downstream regulator. TNFα...
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<div>AbstractPurpose:<p>Because of disease heterogeneity, limited studies on effective chemotherapies and therapeutic agents for advanced gastric cancer are available. Erythrocyte membrane protein band 4.1-like 5 (EPB41L5) has critical roles in renal breast metastasis. However, its role metastatic remains unknown.</p>Experimental Design:<p>The specimens 78 patients were analyzed by oligonucleotide microarray survival analysis. <i>In vitro</i> experiments...
<div>AbstractPurpose:<p>Because of disease heterogeneity, limited studies on effective chemotherapies and therapeutic agents for advanced gastric cancer are available. Erythrocyte membrane protein band 4.1-like 5 (EPB41L5) has critical roles in renal breast metastasis. However, its role metastatic remains unknown.</p>Experimental Design:<p>The specimens 78 patients were analyzed by oligonucleotide microarray survival analysis. <i>In vitro</i> experiments...
<p>Supplementary Data_Tracked Changes</p>