A5040692559- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Thyroid Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal disorders and treatments
- Thyroid and Parathyroid Surgery
- Natural product bioactivities and synthesis
- Retinoids in leukemia and cellular processes
- Neuroendocrine Tumor Research Advances
- Genetic factors in colorectal cancer
- Bioactive Compounds and Antitumor Agents
- Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cancer-related Molecular Pathways
- Radiomics and Machine Learning in Medical Imaging
- Esophageal and GI Pathology
- Cancer, Lipids, and Metabolism
- Cancer Risks and Factors
- Colorectal Cancer Surgical Treatments
- Helicobacter pylori-related gastroenterology studies
Gyeongsang National University Hospital
2015-2024
Gyeongsang National University
2013-2023
Catholic University of Korea
2008-2021
Seoul St. Mary's Hospital
2021
Regional Cancer Center
2012
The University of Texas Medical Branch at Galveston
2008
Duke Medical Center
2008
The University of Texas Health Science Center at Houston
1997
Understanding the molecular background of breast cancer biology is critical in developing new biomarkers for earlier diagnosis and more optimized treatment. We performed a proteomic analysis human carcinoma tissues to investigate tumor-specific protein expression carcinoma. Using 2-dimensional electorphoresis (2-DE) matrix-assisted laser desorption/ionization-time flight-mass spectrometry (MALDI-TOF-MS), we were able identify list proteins which are upregulated cancerous tissue. There was...
Recently, researchers have tried to predict patient prognosis using biomarker expression in cancer patients. The aim of this study was develop a nomogram predicting the 5-year recurrence-free probability (RFP) gastric patients prognostic gene expression.We enrolled 360 training data set predictive model and nomogram. We analyzed patients' general variables levels 10 candidates between nonrecurrence recurrence groups. also performed external validation 420 from set.The final composed age,...
Morin, a flavonoid found in figs and other Moraceae, displays variety of biological actions, such as anti-oxidant, anti-inflammatory anti-carcinogenic. However, the anticancer effects morin particular its anti-metastatic are not well known. Therefore, present study, we investigated on highly metastatic human breast cancer cells. Our results showed that significantly inhibited colony forming ability MDA-MB‑231 cells from low doses (50 µM) without cytotoxicity. In addition, changed cell...
Abstract Hepatocellular carcinoma (HCC) is a common malignancy worldwide and leading cause of death. To contribute to the development improvement molecular markers for diagnostics prognostics therapeutic targets disease, we have largely expanded currently available human liver tissue maps studied differential expression proteins in normal cancer tissues. Reference two‐dimensional electrophoresis (2‐DE) tumor include labeled 2‐DE images total homogenate soluble fraction separated on pH 3–10...
Purpose: The aims are to: (i) display the multidimensional learning curve of totally laparoscopic distal gastrectomy, and (ii) verify feasibility gastrectomy after completion by comparing it with laparoscopy-assisted gastrectomy.Materials Methods: From January 2005 to June 2012, 247 patients who underwent (n=136) (n=111) for early gastric cancer were enrolled.Their clinicopathological characteristics surgical outcomes analyzed.Analysis was conducted using moving average method cumulative sum...
Decoctions of the dried flowers Lonicera japonica Thunb. (Indongcho) have been utilized in folk remedies against various inflammatory diseases, and it is reported neuroprotective effects. The cytokines release from microglia closely linked to chronic neurodegenerative diseases like Alzheimer's disease Parkinson's disease. It still unknown whether effects are associated with antiinflammatory Here, we determined polyphenols extracted lyophilized (PELJ) would inhibit mediators. We stimulated...
Tetraarsenic hexoxide (As4O6) has been used in Korean folk medicines for the treatment of cancer, however its anti-cancer mechanisms remain obscured. Here, this study investigated effect As4O6 on SW620 human colon cancer cells. showed a dose-dependent inhibition cells proliferation. significantly increased sub-G1 and G2/M phase population, Annexin V-positive manner. arrest was concomitant with augment p21 reduction cyclin B1, cell division cycle 2 (cdc 2) expressions. Nuclear condensation,...
Background: Because laparoscopic liver resection (LLR) has a steep learning curve, analyzing experience is important for trainees. Several authors have described the curve of LLR, without comparing curves between major and minor LLR. Methods: Perioperative data were retrieved from medical records 170 consecutive patients who underwent LLR by single surgeon at tertiary hospital. Learning generated compared using cumulative sum control charts moving average. Results: Major was performed in 96...
Rho GDP dissociation inhibitor 2 (RhoGDI2) expression is correlated with tumor growth, metastasis and chemoresistance in gastric cancer. However, the mechanisms by which RhoGDI2 promotes cell survival remain unclear. In this study, we clearly demonstrate that upregulates VEGF-C positively human tissues as well parental cancer lines. depletion suppressed RhoGDI2-induced sensitized RhoGDI2-overexpressing cells to cisplatin-induced apoptosis vitro vivo. Secreted enhanced invasion conferred...
There is no consensus on the optimal treatment of T1b gallbladder cancer (GBC) due to lack evidence and difficulty anatomy pathological standardization.A total 272 patients with GBC who underwent surgical resection at 14 centers specialized hepatobiliary-pancreatic surgeons pathologists in Korea, Japan, Chile, United States were studied. Clinical outcomes including disease-specific survival (DSS) rates according types surgery analyzed.After excluding patients, 237 qualifying consisted 90 men...
The present study is to investigate the significance of CD44 variant 9 (CD44v9) expression as a biomarker in primary gastric cancer.With various tissues, we performed immunohistochemical staining for CD44v9.The positive rates CD44v9 tumor, including adenoma, early cancer (EGC), and advanced (AGC), were higher than those non-tumor tissues (p=0.003). In addition, was observed tissue becomes malignant. analysis 333 found that intestinal type or well differentiated diffuse poorly cancer....
While extended cholecystectomy is recommended for T2 gallbladder cancer (GBC), the role of hepatic resection GBC unclear. This study aimed to identify necessity in patients with GBC. Data 81 histopathologically proven who underwent surgical between January 1999 and December 2017 were enrolled from a retrospective database. Of these, 36 had peritoneal-side (T2a) tumors 45 hepatic-side (T2b) tumors. To optimal management method, classified into group (n = 44, T2a/T2b 20/24) non-hepatic 37,...
Clinical outcomes of papillary thyroid microcarcinoma (PTMC) vary. In general, age at diagnosis is an independent prognostic factor in conventional carcinoma. However, it unclear patients PTMC. The purpose this study was to identify clinicopathologic features and factors PTMC according patients' age.Five hundred twenty-seven who received surgery diagnosed as having PTC between January 2001 December 2009 were included. clinical data retrospectively analyzed.We divided the into two groups;...
Background: The extract of Allium cepa Linn is commonly used as adjuvant food for cancer therapy.We assumed that it includes a potential source anti-cancer properties.Methods: We investigated effects polyphenols extracted from lyophilized A. (PEAL) in AGS human cells.Results: PEAL inhibited cell growth dose-dependent manner.It was related to caspase-dependent apoptosis.We confirmed this finding with annexin V staining.PEAL up-regulated p53 expression, and subsequent Bax induction, down...
Current Status of Laparoscopic Liver Resection in KoreaSince laparoscopic liver resection was first introduced 2001, Korean surgeons have chosen a procedure as one the treatment options for benign or malignant disease.We distributed and analyzed nationwide questionnaire to members Surgery Study Group (KLLSG) order evaluate current status Korea.Questionnaires were sent 24 centers KLLSG.The consisted operative procedure, histological diagnosis lesions, indications resection, causes conversion...
Purpose: Excess weight and obesity have been associated with numerous diseases including thyroid cancer, but the relationship has weak.The objective of this study was to evaluate body sizes on nodules in healthy Korean population.Methods: A total 7,763 persons who underwent a health examination our center were included study.The epidemiologic factors, size ultrasound results reviewed.We investigated effects presence malignancy.Results: The incidence 20.6%.In group found nodules, mean height,...